Albumin human parenteral
- Drugs List
- Therapeutic Indications
- Dosage
- Administration
- Contraindications
- Precautions and Warnings
- Pregnancy and Lactation
- Side Effects
- Monograph
Presentation
Infusions of human albumin.
Drugs List
Therapeutic Indications
Uses
Treatment of hypovolaemia
Dosage
Adults
Dosage and infusion rates should be adjusted depending on the requirements of the individual patient. Dosage will depend on the size of the patient, severity of trauma or illness and on continuing fluid and protein loss.
Dosage should always be based on circulating blood volume and not only plasma albumin levels.
In patients undergoing plasma exchange the infusion rate should be adjusted to the rate of removal.
Children
The posology in children and adolescents (0 to 18 years) should be adjusted to the patient's individual requirements.
Administration
For intravenous infusion.
The manufacturers of some brands of human albumin solution 20% state that the product may be diluted with an isotonic infusion solution such as sodium chloride 0.9% infusion or glucose 5% infusion.
Contraindications
Cardiac failure
Precautions and Warnings
Haemorrhagic diathesis
Restricted potassium intake
Restricted sodium intake
Severe traumatic brain injury
Anuria
History of cardiac disorder
Hypertension
Increased capillary permeability
Oesophageal varices
Pregnancy
Pulmonary oedema
Severe anaemia
Sodium content of formulation may be significant
Maintain adequate hydration during therapy
Restore electrolyte & fluid balance in case of dehydration
Derived from human proteins - transmission of infective agents possible
Consider hepatitis A & B vaccinations if patient receives product regularly
Record name and batch number of administered product
Stop infusion immediately if symptoms of cardiovascular overload appear
Monitor blood pressure
Monitor central venous pressure
Monitor coagulation values
Monitor fluid balance
Monitor haematocrit values
Monitor haemoglobin levels
Monitor heart rate
Monitor patients with cardiovascular disease
Monitor respiratory function
Monitor serum electrolytes
Monitor to prevent cardiovascular overload
Monitor to prevent hypervolaemia
Monitor urine output
Management of cases of shock should follow current medical standards
Discontinue if allergic reaction occurs
Discontinue if anaphylactoid reaction occurs
Discontinue if pulmonary oedema occurs
Discontinue if rise in blood pressure occurs
Sodium and potassium content may vary in each product or batch of products.
Pregnancy and Lactation
Pregnancy
Use human albumin with caution during pregnancy.
The manufacturers states that no adverse effects during pregnancy are anticipated. At the time of writing there is limited published information regarding the use of human albumin during pregnancy.
Lactation
Human albumin is considered safe for use during breastfeeding, as it is a normal constituent of human blood.
Side Effects
Anaphylaxis
Angioneurotic oedema
Bradycardia
Bronchospasm
Chest tightness
Chills
Confusion
Dizziness
Dyspnoea
Erythematous rash
Fever
Flushing
Headache
Hyperhidrosis
Hypersensitivity reactions
Hypertension
Hypotension
Nausea
Pulmonary oedema
Rigors
Sensation of cold
Shock
Stridor
Tachycardia
Tremor
Urticaria
Overdosage
It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.
The following number will direct the caller to the relevant local centre (0844) 892 0111
Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ).
Further Information
Last Full Review Date: May 2019
Reference Sources
Summary of Product Characteristics: Albunorm 5%, 50g/l. Octapharma Ltd. Revised January 2014.
Summary of Product Characteristics: Albunorm 20%, 200g/l. Octapharma Ltd. Revised January 2014.
Summary of Product Characteristics: Alburex 5, 50g/l solution for infusion. CSL Behring UK Limited. Revised September 2018.
Summary of Product Characteristics: Alburex 20, 200g/l solution for infusion. CSL Behring UK Limited. Revised September 2018.
Summary of Product Characteristics: Albutein 50g/L solution for infusion. Grifols UK Ltd. Revised April 2016.
Summary of Product Characteristics: Albutein 200g/L solution for infusion. Grifols UK Ltd. Revised April 2016.
Summary of Product Characteristics: Human Albumin Biotest 5%. Biotest (UK) Ltd. Revised September 2015.
Summary of Product Characteristics: Human Albumin Biotest 20%. Biotest (UK) Ltd. Revised September 2015.
Summary of Product Characteristics: Human Albumin Grifols 50g/l, solution for infusion. Grifols UK Ltd. Revised April 2016.
Summary of Product Characteristics: Human Albumin Grifols 200g/l, solution for infusion. Grifols UK Ltd. Revised April 2016.
Summary of Product Characteristics: Zenalb 4.5, a Human Albumin 4.5% solution. Bio Products Laboratory Limited. Revised July 2012.
Summary of Product Characteristics: Zenalb 20, a Human Albumin 20% solution. Bio Products Laboratory Limited. Revised July 2012.
Summary of Product Characteristics: Zenbumin 20, 200g/l Solution for infusion. Bio Products Laboratory Limited. Revised October 2018.
NICE Evidence Services Available at: www.nice.org.uk Last accessed: 22 May 2019
Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content
FDB Disclaimer : FDB Multilex is intended for the use of healthcare professionals and is provided on the basis that the healthcare professionals will retain FULL and SOLE responsibility for deciding what treatment to prescribe or dispense for any particular patient or circumstance.