This site is intended for UK healthcare professionals
Medscape UK Univadis Logo
Medscape UK Univadis Logo

Anidulafungin parenteral

Updated 2 Feb 2023 | Echinocandin antifungals


Parenteral formulation of anidulafungin.

Drugs List

  • anidulafungin 100mg powder for concentrate for solution for infusion
  • ECALTA 100mg powder for concentrate for solution for infusion
  • Therapeutic Indications


    Invasive candidiasis: treatment



    200mg loading dose should be administered on day 1, followed by 100mg daily thereafter.

    Usually, the treatment should continue for at least 14 days after the last positive culture. There is inadequate data to support the 100mg dose for longer than 35 days.


    A single loading dose of 3mg/kg (not to exceed 200mg) should be administered on day 1, followed by a daily maintenance dose of 1.5mg/kg (not to exceed 100mg) thereafter.

    Usually, the treatment should continue for at least 14 days after the last positive culture.


    For intravenous infusion only, after reconstitution and dilution.

    The rate of infusion should not exceed 1.1mg/minute (1.4ml/minute of the diluted infusion solution). Infusion related reactions are less frequent when the rate does not exceed 1.1mg/minute.


    Hereditary fructose intolerance

    Precautions and Warnings

    Children 1 month to 18 years

    Consult national/regional policy on the use of anti-infectives
    Not all available products are licensed for all age groups
    Treatment to be initiated and supervised by a specialist
    Contains fructose
    Concentrate must be diluted and used as an infusion
    Monitor hepatic enzymes. Assess benefit/risk if significant rise
    Monitor patient for infusion-associated reactions (IARs)
    Discontinue if serious allergic or anaphylactic reaction occurs

    Anidulafungin has not been studied in patients with Candida endocarditis, osteomyelitis or meningitis. There is not enough experience with the use of anidulafungin in neutropenic patients.

    Before therapy is initiated, specimens for fungal culture should be taken. Therapy may be started before the results of these tests are known and dosage may be adjusted accordingly when results are obtained.

    Pregnancy and Lactation


    Anidulafungin is contraindicated during pregnancy.

    The manufacturer recommends anidulafungin is avoided in pregnancy, unless the benefit to the mother clearly outweighs the potential risk to the developing foetus. Animal studies have shown anidulafungin to cross the placenta, and reproductive toxicity has been documented. At the time of writing, there are insufficient data regarding the use of anidulafungin during pregnancy.


    Anidulafungin is contraindicated during breastfeeding.

    The manufacturer recommends evaluating the benefits of breastfeeding for the child against the benefits of therapy for the breastfeeding woman, and discontinuing either anidulafungin therapy or breastfeeding accordingly. It is not known if anidulafungin is excreted in human breast milk, but animal studies have shown excretion of anidulafungin in animal milk. Anidulafungin's large molecular weight but long degradation half-life and moderate plasma protein binding suggest that excretion into breast milk may occur. The potential effect on the nursing infant is unknown.

    Side Effects

    Anaphylactic reaction
    Anaphylactic shock
    Coagulation disorders
    Gamma glutamyl transferase (GGT) increased
    Hot flushes
    Increase in alkaline phosphatase
    Increase in serum ALT/AST
    Infusion-related symptoms
    Local pain (injection site)
    Serum bilirubin increased
    Serum creatinine increased
    Upper abdominal pain


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: February 2022.

    Reference Sources

    Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 10th edition (2015) ed. Briggs, G., Freeman, R. Wolters Kluwer Health, Philadelphia.

    Summary of Product Characteristics: Anidulafungin 100mg powder for concentrate for solution for infusion. Wockhardt UK Ltd. Revised March 2020.

    Summary of Product Characteristics: Ecalta 100mg powder for solution for concentrate for infusion. Pfizer Ltd. Revised October 2020.

    Access the full UK drug database with a FREE Medscape UK Account
    It takes just a few minutes, and you’ll get unlimited access to information on over 11,000 UK drugs.
    Register for Free

    Already a member? Log in

    Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content

    FDB Logo

    FDB Disclaimer : FDB Multilex is intended for the use of healthcare professionals and is provided on the basis that the healthcare professionals will retain FULL and SOLE responsibility for deciding what treatment to prescribe or dispense for any particular patient or circumstance.