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Articaine with adrenaline injection

Updated 2 Feb 2023 | Other local anaesthetics


Solution for injection containing articaine hydrochloride and adrenaline

Drugs List

  • articaine 88mg/2.2ml and adrenaline 11microgram/2.2ml (1:200000) injection
  • articaine 88mg/2.2ml and adrenaline 22microgram/2.2ml (1:100000) injection
  • SEPTANEST 1:100000 injection
  • SEPTANEST 1:200000 injection
  • Therapeutic Indications


    Local anaesthetic for dental infiltration anaesthesia



    For most common procedures, one filtration with 1.7 ml articaine with adrenaline is sufficient. In all cases, the injection must be administered slowly at about 1 ml/minute.

    Infiltration in the interdental septum usually requires 0.3 ml to 0.5 ml of articaine with adrenaline. Higher volumes should rarely be required.

    Do not exceed the equivalent of 7 mg articaine hydrochloride per kg body weight. Anaesthesia is obtained rapidly in 2 to 5 minutes.


    The recommended dosage in children is calculated based on their weight.

    Over 4 years
    Simple procedures
    0.06 ml/kg infiltrated slowly (1 ml per minute)

    Complex procedures
    0.07 ml/kg infiltrated slowly (1 ml per minute)

    Maximum dose of 0.175 ml/kg infiltrated slowly (1 ml per minute)

    Additional Dosage Information

    To avoid excessive dosage in obese patients, dose should be calculated on the basis of ideal weight.


    For dental injection only.

    Solution for injection containing 88 mg of articaine hydrochloride and 11 micrograms (1:200,000) of adrenaline per 2.2 ml cartridge administered by infiltration or nerve block injection provides pulpal analgesia that lasts 60 minutes.

    Solution for injection containing 88 mg of articaine hydrochloride and 22 micrograms (1:100,000) of adrenaline per 2.2 ml cartridge administered by infiltration or nerve block injection provides pulpal analgesia that lasts 75 minutes and bleeding during the operation is significantly reduced.


    Children under 4 years
    General anaesthesia
    Plasma cholinesterase deficiency

    Precautions and Warnings

    Administration site infection
    Inflammation of injection site
    Cardiac conduction defects
    Cardiogenic shock
    Cardiovascular disorder
    Diabetes mellitus
    Epileptic disorder
    Hepatic impairment
    Myasthenia gravis
    Peripheral vascular disease
    Respiratory impairment

    Advise ability to drive/operate machinery may be affected by side effects
    Contains sodium metabisulfite. Caution,may cause allergic reactions
    Avoid accidental intravascular injection
    Effect may be reduced if injected into an inflamed or infected area
    Resuscitation facilities must be immediately available
    Anaesthetic effect may impair swallowing
    In obese patients dosing should be based on ideal weight

    Intravascular injection is strictly contraindicated because of the risk of systemic adverse effects due to circulating adrenaline and/or articaine.

    Patients with severe hepatic impairment have an increased risk of developing toxic plasma concentrations.

    Patients with peripheral vascular disease or hypertensive vascular disease may have an exaggerated vasoconstrictor response which may result in ischaemic injury or necrosis.

    Allergic type reactions may occur in patients with bronchial asthma due to hypersensitivity to the sulfite component.

    Pregnancy and Lactation


    Articaine with adrenaline anaesthesia should be used with caution in pregnancy.

    There is no clinical experience in the use of articaine with adrenaline in pregnant women. The safety of local anaesthetics during pregnancy has not been established with respect to adverse effects on the development of the foetus. The manufacturer recommends that articaine with adrenaline anaesthesia should only be used during pregnancy when the benefits are considered to outweigh the risks.

    The use of all medication in pregnancy should be avoided whenever possible; particularly in the first trimester. Non-drug treatments should also be considered. When essential, a medication with the best safety record over time should be chosen, employing the lowest effective dose for the shortest possible time. Polypharmacy should be avoided. Teratogens taken in the pre-embryonic period, often quoted as lasting until 14 to 17 days post-conception, are believed to have an all-or-nothing effect. Where drugs have a short half-life, and when the date of conception is certain, this may allow women to be reassured where drug exposure has occurred within this time frame. Further advice may be available from the UK National Teratology Information Service (NTIS) and through ToxBase, available via password on the internet ( ) or if this is unavailable at the backup site ( ).


    Articaine with adrenaline anaesthesia is contraindicated in breastfeeding.

    There is no clinical experience in the use of articaine with adrenaline in breastfeeding women. It is not known whether articaine or its metabolites are excreted into human milk. The manufacturer recommends that nursing mothers should not breastfeed for 48 hours following anaesthesia with articaine and adrenaline.

    Neonates, infants born prematurely, those with low birth weight, those with an unstable gastrointestinal function or who have serious illnesses may require special consideration. For any infant, if a drug is prescribed to the nursing mother, it should be at the lowest practical dose and for the shortest time. When drug administration is unavoidable and breastfeeding is to continue, minimisation of exposure of the infant to the drug may sometimes be achieved by timing the maternal doses to just after a feeding episode. Infants exposed to drugs via breast milk should be monitored for unusual signs or symptoms. Interactions between the drug received by the infant from the mother's milk and medication prescribed for the infant should also be considered, for example, when the drug given to the infant may prevent metabolism of the drug received via breast milk.
    Specialist advice is available from the UK Drugs in Lactation Advisory Service at

    Side Effects

    Decrease in blood pressure
    Decrease in heart rate
    Facial oedema
    Hearing disturbances
    Hypersensitivity reactions
    Necrosis (injection site)


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: May 2016

    Reference Sources

    Joint Formulary Committee. British National Formulary. 71st ed. London: BMJ Group and Pharmaceutical Press; 2016.

    Paediatric Formulary Committee. BNF for Children 2015-2016. London: BMJ Group, Pharmaceutical Press, and RCPCH Publications; 2015.

    Summary of Product Characteristics: Septanest 1:100,000. Septodont Ltd. Revised June 2012.

    Summary of Product Characteristics: Septanest 1:200,00. Septodont Ltd. Revised June 2012.

    UK Drugs in Lactation Advisory Service.
    Available at:
    Last accessed: 18 May 2016

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