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Ascorbic acid parenteral

Presentation

Parenteral formulations of ascorbic acid.

Drugs List

  • ascorbic acid 500mg/5ml solution for injection ampoule
  • Therapeutic Indications

    Uses

    Vitamin C deficiency
    Vitamin C deficiency - prophylaxis

    Prevention and treatment of scurvy, or other conditions requiring vitamin C supplementation, where oral administration is difficult or the deficiency acute.

    Unlicensed Uses

    Adjunct to desferrioxamine
    Metabolic disorders

    Dosage

    Adults

    Treatment of scurvy
    500mg to 1g daily

    Prevention of scurvy
    200mg to 500mg daily

    Children

    Treatment of scurvy
    100mg to 300mg daily.

    Prevention of scurvy
    30mg daily.

    Contraindications

    Hyperoxaluria

    Precautions and Warnings

    Cardiac impairment
    Chronic renal failure
    G6PD deficiency
    Pregnancy

    May affect results of some laboratory tests
    Deficiency may result if withdrawn rapidly after prolonged high doses
    Pregnancy: Do not exceed 1 gram of vitamin C daily

    Pregnancy and Lactation

    Pregnancy

    Use ascorbic acid with caution during pregnancy.

    The manufacturer does not recommend using ascorbic acid at doses greater than 1g daily during pregnancy. Lower doses may be used with caution. At the time of writing there is limited published information regarding the use of ascorbic acid during pregnancy.

    Lactation

    Ascorbic acid is considered safe for use during breastfeeding.

    The manufacturer states ascorbic acid may be used safely when breastfeeding. Whilst available data indicates ascorbic acid is present in human breast milk, there is no evidence of any hazard.

    Side Effects

    Diarrhoea
    Fatigue
    Gastro-intestinal symptoms
    Headache
    Hot and flushed skin
    Hyperoxaluria
    Increased urination
    Nausea
    Renal calculus
    Vomiting

    Overdosage

    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ).

    Further Information

    Last Full Review Date: November 2021

    Reference Sources

    Summary of Product Characteristics: Ascorbic Acid Injection 500mg/5ml. Phoenix Labs. Revised May 2018.

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