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Atovaquone oral

Updated 2 Feb 2023 | Pneumocystis pneumonia


Oral formulations of atovaquone.

Drugs List

  • atovaquone 750mg/5ml oral suspension sugar-free
  • WELLVONE 750mg/5ml suspension
  • Therapeutic Indications


    Mild-mod Pneumocystis jiroveci pneumonia in pts intolerant of cotrimoxazole

    Unlicensed Uses

    Prophylaxis of pneumocystis jirovecii pneumonia in immunodeficiency



    Treatment of Pneumocystis jirovecii pneumonia
    750mg twice a day for twenty one days.

    Prophylaxis against Pneumocystis jirovecii pneumonia (unlicensed)
    750mg twice a day.


    Treatment of Pneumocystis jirovecii pneumonia (unlicensed)
    Children aged 2 to 18 years
    15mg/kg to 20mg/kg (up to 750mg per dose) twice a day for fourteen to twenty one days.
    Children aged 3 months to 2 years
    22.5mg/kg twice a day for fourteen to twenty one days.
    Children aged 1 to 3 months
    15mg/kg to 20mg/kg twice a day for fourteen to twenty one days.


    Neonates under 1 month

    Precautions and Warnings

    Children 1 month to 18 years
    Hepatic impairment
    Pulmonary disease
    Renal impairment

    Contains benzyl alcohol
    Take with food - particularly high fat food
    Monitor patients with hepatic impairment
    Monitor patients with renal impairment
    Diarrhoea at start of treatment lowers absorption - consider alternative
    Inability to take with food lowers absorption - consider alternative

    Patients with pulmonary disease should be evaluated for other causes of disease (other than PCP). Additional agents should be administered as required.

    The manufacturer states that use in children under 3 years (unlicensed) should be restricted to one week or less due to risk of accumulation of benzyl alcohol.

    Pregnancy and Lactation


    Use atovaquone with caution during pregnancy.

    The manufacturer does not recommend using atovaquone in pregnancy unless the benefit of treatment to the mother would outweigh the risk to the foetus. At the time of writing there is limited published information regarding the use of atovaquone during pregnancy. Potential risks are unknown.


    Atovaquone is contraindicated in breastfeeding.

    Use of atovaquone when breastfeeding is contraindicated by the manufacturer. The presence of atovaquone in human breast milk is unknown. Effects on exposed infants are unknown.

    Side Effects

    Elevated amylase levels
    Erythema multiforme
    Hypersensitivity reactions
    Increases in hepatic enzymes
    Stevens-Johnson syndrome
    Throat tightness


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: January 2023

    Reference Sources

    Summary of Product Characteristics: Wellvone 750mg/5ml oral suspension. GlaxoSmithKline UK. Revised July 2022.

    NICE Evidence Services Available at: Last accessed: 23 January 2023

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