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Benralizumab parenteral

Updated 2 Feb 2023 | Interleukin antagonist

Presentation

Injection solution of benralizumab.

Drugs List

  • benralizumab pre-filled pen 30mg/1ml injection solution
  • benralizumab pre-filled syringe 30mg/1ml injection solution
  • FASENRA PRE-FILLED PEN 30mg/1ml injection solution
  • FASENRA PRE-FILLED SYRINGE 30mg/1ml injection solution
  • Therapeutic Indications

    Uses

    Severe eosinophilic asthma: Add-on maintenance treatment

    Dosage

    Patients may self administer following appropriate training.

    Continuation of treatment should be assessed on the yearly basis taking into account the disease severity, level of exacerbation control and counts of blood eosinophils.

    Adults

    30mg by subcutaneous injection every 4 weeks for the first 3 doses, followed by 30mg every 8 weeks thereafter.

    Additional Dosage Information

    In the event of a missed dose benralizumab should be administered as soon as possible following the planned dates and avoiding the double dose.

    Administration

    Subcutaneous injection into the thigh or abdomen.
    The upper arm can be used if administered by a healthcare professional or a carer.

    Contraindications

    Children under 18 years
    Breastfeeding

    Precautions and Warnings

    History of anaphylaxis
    Susceptibility to helminth infections
    Pregnancy

    Not suitable for acute treatment of asthma
    Avoid abrupt withdrawal of concurrent corticosteroids
    Treat helminth infection before initiation of therapy
    Treatment to be prescribed under the supervision of a specialist
    Contains polysorbate
    Avoid injection into broken or bruised skin
    Consider temporary discontinuation if helminth infection occurs
    Discontinue if hypersensitivity reactions occur
    Advise patient to consult physician if condition worsens / does not improve

    Pregnancy and Lactation

    Pregnancy

    Use benralizumab with caution during pregnancy.

    The manufacturer advises that it is preferable to avoid benralizumab during pregnancy.

    There is an increased potential for exposure to the fetus during the second and third trimester of pregnancy.

    Animal studies do not show any maternal, embryo-foetal and postnatal effects of benralizumab administration.

    Lactation

    Benralizumab is contraindicated during breastfeeding.

    The manufacturer advises that the patient either discontinues benralizumab or discontinues breastfeeding.

    The presence of benralizumab in human breast milk is unknown but due to its high molecular weight it is predicted that the amount in milk is likely to be very low.

    Side Effects

    Anaphylactic reaction
    Headache
    Hypersensitivity reactions
    Injection site reactions
    Pharyngitis
    Pyrexia

    Overdosage

    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ).

    Further Information

    Last Full Review Date: November 2021

    Reference Sources

    Summary of Product Characteristics: Fasenra 30mg solution for injection in pre-filled syringe and in pre-filled pen. AstraZeneca UK Limited. Revised January 2021.

    US National Library of Medicine. Toxicology Data Network. Drugs and Lactation Database (LactMed).
    Available at: https://www.ncbi.nlm.nih.gov/books/NBK501922/
    Benralizumab Last revised: 20 July 2020
    Last accessed: 30 November 2021

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    Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content

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