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Betamethasone valerate and fusidic acid cream


Topical cream containing fusidic acid and betamethasone.

Drugs List

  • betamethasone 0.1% and fusidic acid 2% cream
  • FUCIBET cream
  • XEMACORT cream
  • Therapeutic Indications


    Inflammatory skin conditions responsive to corticosteroid and antimicrobial



    Apply a small quantity to the affected area twice daily until a satisfactory response is obtained.

    A single treatment course should not normally exceed 2 weeks.

    Occlusion with polythene film can enhance the effect of the cream in more resistant lesions. Overnight occlusion is usually adequate.


    (See Dosage; Adults).


    (See Dosage; Adults).


    Uncontrolled systemic infection
    Acne vulgaris
    Perioral dermatitis
    Skin infection

    Precautions and Warnings

    Children under 6 years

    May mask symptoms or signs of infections
    Exclude fungal infection before treatment
    Exclude tubercular infection before treatment
    Exclude viral infection before treatment
    Not all available brands are licensed for all age groups
    Avoid contact with eyes
    Risk of glaucoma if preparation enters eye
    Adrenal suppression may occur even without occlusion
    Prolonged use may cause atrophic skin changes
    Discontinue if hypersensitivity reactions occur
    Avoid long term continuous therapy
    Each course of treatment should not exceed 14 days
    Advise patient residue on clothing/bedding may cause fire hazard
    Fire hazard: Keep away from naked flames and potential sources of ignition
    Nappy may act as an occlusive dressing

    Bacterial resistance has been reported with the use of fusidic acid. Extended or recurrent applications may increase the risk of developing antibiotic resistance.

    Occult extension of the infection may occur due to the masking of the steroid.

    If the infection persists, systemic therapy may be required.

    The steroid component of the cream may mask hypersensitivity reactions.

    Pregnancy and Lactation


    Betamethasone with fusidic is contraindicated in pregnancy.

    Betamethasone valerate
    Topical application of corticosteroids to pregnant animals can cause abnormalities of foetal development including cleft palate and intrauterine growth retardation. There may therefore be a very small risk of such effects in the human foetus but the relevance of this study has not been established in humans. Nevertheless, topical corticosteroids with the exception of very potent steroids can be used relatively safely in pregnancy (Schaefer, 2007).

    Fusidic acid
    At the time of writing no effects during pregnancy are anticipated, since systemic exposure to fusidic acid is negligible. Studies in animals have not shown teratogenic effects with fusidic acid. Limited studies in animals have shown negligible systemic absorption of topical fusidic acid.

    The use of all medication in pregnancy should be avoided whenever possible; particularly in the first trimester. Non-drug treatments should also be considered. When essential, a medication with the best safety record over time should be chosen, employing the lowest effective dose for the shortest possible time. Polypharmacy should be avoided. Teratogens taken in the pre-embryonic period, often quoted as lasting until 14 to 17 days post-conception, are believed to have an all-or-nothing effect. Where drugs have a short half-life, and when the date of conception is certain, this may allow women to be reassured where drug exposure has occurred within this time frame. Further advice may be available from the UK National Teratology Information Service (NTIS) and through ToxBase, available via password on the internet ( ) or if this is unavailable at the backup site ( ).


    Betamethasone with fusidic acid is considered safe for use in breastfeeding.

    At the time of no effects on the infant are anticipated since the systemic exposure to the breastfeeding woman to fusidic acid and betamethasone is negligible. Fusidic acid with betamethasone should not be applied on the breasts to avoid accidental ingestion by the infant.

    Neonates, infants born prematurely, those with low birth weight, those with an unstable gastrointestinal function or who have serious illnesses may require special consideration. For any infant, if a drug is prescribed to the nursing mother, it should be at the lowest practical dose and for the shortest time. When drug administration is unavoidable and breastfeeding is to continue, minimisation of exposure of the infant to the drug may sometimes be achieved by timing the maternal doses to just after a feeding episode. Infants exposed to drugs via breast milk should be monitored for unusual signs or symptoms. Interactions between the drug received by the infant from the mother's milk and medication prescribed for the infant should also be considered, for example, when the drug given to the infant may prevent metabolism of the drug received via breast milk.
    Specialist advice is available from the UK Drugs in Lactation Advisory Service at

    Side Effects

    Acne (at application site)
    Adrenal suppression
    Allergic reaction
    Burning sensation (local)
    Contact dermatitis
    Dry skin
    Exacerbation of acne
    Exacerbation of pre-existing eczema
    Perioral dermatitis
    Skin atrophy
    Skin depigmentation
    Skin irritation
    Worsening of rosacea


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: June 2016

    Reference Sources

    Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment, 2nd edition (2007) ed. Schaefer, C., Peters, P. and Miller, R. Elsevier, London.

    Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 10th edition (2015) ed. Briggs, G., Freeman, R. Wolters Kluwer Health, Philadelphia.

    Joint Formulary Committee. British National Formulary (online) London: BMJ Group and Pharmaceutical Press Accessed on 23 June 2016.

    Paediatric Formulary Committee. BNF for Children (online) London: BMJ Group, Pharmaceutical Press, and RCPCH Publications Accessed on 23 June 2016.

    Summary of Product Characteristics: FuciBET cream. Leo Laboratories Ltd. Revised September 2015.
    Summary of Product Characteristics: Fucibet Lipid cream. Leo Laboratories Ltd. Revised September 2015.

    Summary of Product Characteristics: Xemacort 20mg/g + 1mg/g cream. Mylan Ltd. Revised May 2015.

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