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Cetrimide with chlorhexidine topical


Topical formulations of cetrimide with chlorhexidine

Drugs List

  • cetrimide 0.15% and chlorhexidine 0.015% sterile solution
  • cetrimide 0.15% and chlorhexidine acetate 0.015% sterile solution
  • Therapeutic Indications


    Minor wound treatment
    Skin disinfection


    None known

    Precautions and Warnings

    Premature infants

    Some formulations contain hydroxybenzoate
    Avoid contact with mucous membranes
    Avoid contact with the mouth
    Do not allow to come into contact with eyes, middle ear, brain or meninges
    If accidental contact with eyes or mucous membranes - rinse with cool water
    Not for use in body cavities
    Premature infants: Risk of severe chemical injury
    Prolonged topical application may cause sensitisation reactions
    Discontinue if irritation or sensitisation occur

    Pregnancy and Lactation


    Cetrimide with chlorhexidine is considered safe for use in pregnancy.

    The use of all medication in pregnancy should be avoided whenever possible; particularly in the first trimester. Non-drug treatments should also be considered. When essential, a medication with the best safety record over time should be chosen, employing the lowest effective dose for the shortest possible time. Polypharmacy should be avoided. Teratogens taken in the pre-embryonic period, often quoted as lasting until 14 to 17 days post-conception, are believed to have an all-or-nothing effect. Where drugs have a short half-life, and when the date of conception is certain, this may allow women to be reassured where drug exposure has occurred within this time frame. Further advice may be available from the UK National Teratology Information Service (NTIS) and through ToxBase, available via password on the internet ( ) or if this is unavailable at the backup site ( ).


    Cetrimide with chlorhexidine is considered safe for use in breastfeeding.

    Neonates, infants born prematurely, those with low birth weight, those with an unstable gastrointestinal function or who have serious illnesses may require special consideration. For any infant, if a drug is prescribed to the nursing mother, it should be at the lowest practical dose and for the shortest time. When drug administration is unavoidable and breastfeeding is to continue, minimisation of exposure of the infant to the drug may sometimes be achieved by timing the maternal doses to just after a feeding episode. Infants exposed to drugs via breast milk should be monitored for unusual signs or symptoms. Interactions between the drug received by the infant from the mother's milk and medication prescribed for the infant should also be considered, for example, when the drug given to the infant may prevent metabolism of the drug received via breast milk.
    Specialist advice is available from the UK Drugs in Lactation Advisory Service at

    Side Effects

    Anaphylactic shock
    Hypersensitivity reactions
    Skin irritation


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: May 2016

    Reference Sources

    Summary of Product Characteristics: Chlorhexidine acetate 0.015% w/v and cetrimide 0.15% w/v, irrigation. Baxter Healthcare Ltd. Revised January 2013.

    Summary of Product Characteristics: Savlon antiseptic cream. Novartis Consumer Health UK Ltd. Revised September 2015.

    Summary of Product Characteristics: Sterets tisept sachets. Medlock Medical Ltd. Revised December 2014.

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    Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content

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    FDB Disclaimer : FDB Multilex is intended for the use of healthcare professionals and is provided on the basis that the healthcare professionals will retain FULL and SOLE responsibility for deciding what treatment to prescribe or dispense for any particular patient or circumstance.