Chloroprocaine perineural injection
- Drugs List
- Therapeutic Indications
- Precautions and Warnings
- Pregnancy and Lactation
- Side Effects
Solution for injection of chloroprocaine.
Perineural block in surgical anaesthesia
Perineural anaesthesia (peripheral nerve block) in adults for short-duration surgeries (not exceeding 60 minutes).
Dosage must be established on an individual basis.
The dose varies depending on the anaesthetic procedure, the vascularity of the tissues, the depth of anaesthesia and degree of muscle relaxation is required, the duration of anaesthesia desired, and the physical condition of the patient.
The maximum recommended dose in adults is 11mg/kg, not to exceed a maximum total dose of 800mg of chloroprocaine hydrochloride.
The duration of action is dose-dependent.
For perineural use (peripheral nerve block).
Children under 18 years
Cardiac conduction defects
Precautions and Warnings
Females of childbearing potential
Plasma cholinesterase deficiency
Severe hepatic disorder
Severe renal impairment
Refer to product information for use in peridural/spinal anaesthesia
Advise ability to drive/operate machinery may be affected by side effects
Treatment to be initiated and supervised by a specialist
Administer injection slowly
Discard any unused portion
Do not inject near site of skin infection
Do not use if any signs of precipitate or particulate matter apparent
For single use only
Resuscitation facilities must be immediately available
Monitor renal function in elderly patients
Reduce dose in elderly
Start treatment at lowest recommended dose
Female: Ensure adequate contraception during treatment
Pregnancy and Lactation
Use chloroprocaine with caution during pregnancy.
The manufacturer does not recommend using chloroprocaine during pregnancy.
Use chloroprocaine with caution during breastfeeding.
The manufacturer advises caution if chloroprocaine is used when breastfeeding. It is unknown if chloroprocaine is excreted in human milk.
Rise in body temperature
It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.
The following number will direct the caller to the relevant local centre (0844) 892 0111
Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ).
Last Full Review Date: June 2020
Summary of Product Characteristics: Ampres 20mg/ml solution for injection. Sintetica Limited. Revised February 2020.
US National Library of Medicine. Toxicology Data Network. Drugs and Lactation Database (LactMed).
Available at: https://www.ncbi.nlm.nih.gov/books/NBK501922/
Chloroprocaine Last revised: 31 October 2018
Last accessed: 10 June 2020
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Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content
FDB Disclaimer : FDB Multilex is intended for the use of healthcare professionals and is provided on the basis that the healthcare professionals will retain FULL and SOLE responsibility for deciding what treatment to prescribe or dispense for any particular patient or circumstance.