Drugs List

Therapeutic Indications

Uses

Perineural block in surgical anaesthesia

Perineural anaesthesia (peripheral nerve block) in adults for short-duration surgeries (not exceeding 60 minutes).

Administration

For perineural use (peripheral nerve block).

Contraindications

Children under 18 years
Cardiac conduction defects
Hypovolaemia

Precautions and Warnings

Elderly
Females of childbearing potential
Plasma cholinesterase deficiency
Breastfeeding
Pregnancy
Severe hepatic disorder
Severe renal impairment

Refer to product information for use in peridural/spinal anaesthesia
Advise ability to drive/operate machinery may be affected by side effects
Treatment to be initiated and supervised by a specialist
Administer injection slowly
Discard any unused portion
Do not inject near site of skin infection
Do not use if any signs of precipitate or particulate matter apparent
For single use only
Resuscitation facilities must be immediately available
Monitor renal function in elderly patients
Reduce dose in elderly
Start treatment at lowest recommended dose
Female: Ensure adequate contraception during treatment

Pregnancy and Lactation

Pregnancy

Use chloroprocaine with caution during pregnancy.

The manufacturer does not recommend using chloroprocaine during pregnancy.

Lactation

Use chloroprocaine with caution during breastfeeding.

The manufacturer advises caution if chloroprocaine is used when breastfeeding. It is unknown if chloroprocaine is excreted in human milk.

Side Effects

Airway obstruction
Anaesthetic complications
Anaphylactoid reaction
Angioneurotic oedema
Anxiety
Arrhythmias
Blurred vision
Bowel dysfunction
Bradycardia
Cardiac arrest
Circumoral paraesthesia
CNS toxicity
Convulsions
Diplopia
Dizziness
Drowsiness
Dyspnoea
Erythema
Hearing disturbances
Hypersensitivity reactions
Hypertension
Hypotension
Laryngeal oedema
Myocardial depression
Nausea
Nerve damage
Neurological damage
Neuropathy
Paraesthesia
Pruritus
Respiratory arrest
Restlessness
Rise in body temperature
Sexual dysfunction
Shaking
Sneezing
Speech disturbances
Sweating
Syncope
Tachycardia
Tinnitus
Tongue numbness
Tremor
Unconsciousness
Urinary dysfunction
Urticaria
Visual disturbances
Vomiting

Presentation

Solution for injection of chloroprocaine.

Drugs List

Therapeutic Indications

Uses

Perineural block in surgical anaesthesia

Perineural anaesthesia (peripheral nerve block) in adults for short-duration surgeries (not exceeding 60 minutes).

Dosage

Dosage must be established on an individual basis.

The dose varies depending on the anaesthetic procedure, the vascularity of the tissues, the depth of anaesthesia and degree of muscle relaxation is required, the duration of anaesthesia desired, and the physical condition of the patient.

Adults

Administration

For perineural use (peripheral nerve block).

Contraindications

Children under 18 years
Cardiac conduction defects
Hypovolaemia

Precautions and Warnings

Elderly
Females of childbearing potential
Plasma cholinesterase deficiency
Breastfeeding
Pregnancy
Severe hepatic disorder
Severe renal impairment

Refer to product information for use in peridural/spinal anaesthesia
Advise ability to drive/operate machinery may be affected by side effects
Treatment to be initiated and supervised by a specialist
Administer injection slowly
Discard any unused portion
Do not inject near site of skin infection
Do not use if any signs of precipitate or particulate matter apparent
For single use only
Resuscitation facilities must be immediately available
Monitor renal function in elderly patients
Reduce dose in elderly
Start treatment at lowest recommended dose
Female: Ensure adequate contraception during treatment

Pregnancy and Lactation

Pregnancy

Use chloroprocaine with caution during pregnancy.

The manufacturer does not recommend using chloroprocaine during pregnancy.

Lactation

Use chloroprocaine with caution during breastfeeding.

The manufacturer advises caution if chloroprocaine is used when breastfeeding. It is unknown if chloroprocaine is excreted in human milk.

Side Effects

Airway obstruction
Anaesthetic complications
Anaphylactoid reaction
Angioneurotic oedema
Anxiety
Arrhythmias
Blurred vision
Bowel dysfunction
Bradycardia
Cardiac arrest
Circumoral paraesthesia
CNS toxicity
Convulsions
Diplopia
Dizziness
Drowsiness
Dyspnoea
Erythema
Hearing disturbances
Hypersensitivity reactions
Hypertension
Hypotension
Laryngeal oedema
Myocardial depression
Nausea
Nerve damage
Neurological damage
Neuropathy
Paraesthesia
Pruritus
Respiratory arrest
Restlessness
Rise in body temperature
Sexual dysfunction
Shaking
Sneezing
Speech disturbances
Sweating
Syncope
Tachycardia
Tinnitus
Tongue numbness
Tremor
Unconsciousness
Urinary dysfunction
Urticaria
Visual disturbances
Vomiting

Overdosage

It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

The following number will direct the caller to the relevant local centre (0844) 892 0111

Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ).

Further Information

Last Full Review Date: June 2020

Reference Sources

Summary of Product Characteristics: Ampres 20mg/ml solution for injection. Sintetica Limited. Revised February 2020.

US National Library of Medicine. Toxicology Data Network. Drugs and Lactation Database (LactMed).
Available at: https://www.ncbi.nlm.nih.gov/books/NBK501922/
Chloroprocaine Last revised: 31 October 2018
Last accessed: 10 June 2020