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Co-danthramer (dantron and poloxamer) oral formulations

Updated 2 Feb 2023 | Stimulant laxatives


Oral formulations of co-danthramer.

Drugs List

  • co-danthramer (dantron 25mg/5ml and poloxamer 200mg/5ml) suspension sugar-free
  • co-danthramer forte (dantron 75mg/5ml and poloxamer 1g/5ml) oral suspension sugar-free
  • Therapeutic Indications


    Constipation in terminally ill patients



    5ml to 10ml to be taken at bedtime.

    Strong suspension
    5ml to be taken at bedtime.


    Children aged 12 to 18 years
    5ml to 10ml to be taken at bedtime.

    Children under 12 years
    2.5ml to 5ml to be taken at bedtime.

    Strong suspension
    Children aged 12 to 18 years
    5ml to be taken at bedtime.


    Abdominal pain of unknown cause
    Infants in nappies
    Gastrointestinal obstruction
    Hereditary fructose intolerance
    Inflammatory bowel disease
    Severe dehydration

    Precautions and Warnings

    Children under 12 years
    Epileptic disorder
    Faecal incontinence
    Hepatic disorder

    Advise patient ability to drive or operate machinery may be impaired
    Not all available brands are licensed for use in children under 12 years
    Restricted use - terminally ill patients only
    Contains alcohol
    Contains parabens
    Oral liquid contains propylene glycol
    Presentations with sorbitol unsuitable in hereditary fructose intolerance
    Avoid prolonged contact with skin
    Risk of adenocarcinoma of the bowel and liver
    May colour urine red
    Not for long term use

    In the presence of renal failure or insufficiency, hypermagnesemia may occur.

    Concurrent use with a stool softener laxative may enhance the systemic absorption of dantron.

    Pregnancy and Lactation


    Co-danthramer is contraindicated during pregnancy.

    Use of co-danthramer during pregnancy is contraindicated by the manufacturer.

    Rodent studies indicate potential carcinogenic risk. At the time of writing there is limited human data available. Risks are unknown.


    Co-danthramer is contraindicated during breastfeeding.

    Use of co-danthramer when breastfeeding is contraindicated by the manufacturer.

    Dantron is excreted in breast milk. The risk to humans is unknown.

    Side Effects

    Abdominal cramps
    Discolouration of mucosa of the large intestine
    Red colouring of perianal skin
    Red urine
    Sloughing of tissue


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: January 2020

    Reference Sources

    Summary of Product Characteristics: Co-Danthramer 25mg/200mg per 5ml Oral Suspension. Pinewood Healthcare. Revised July 2019.

    Summary of Product Characteristics: Co-Danthramer 75mg/1000mg per 5ml Oral Suspension. Pinewood Healthcare. Revised July 2019.

    NICE Evidence Services Available at: Last accessed: 16 January 2020

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