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Presentation

Cream containing 10% crotamiton
Topical emulsion containing 10% crotamiton

Drugs List

  • crotamiton 10% cream
  • EURAX cream
  • Therapeutic Indications

    Uses

    Relief of pruritus caused by, for example sunburn, dry eczema, itchy dermatitis, allergic rashes, hives, nettle rash, chickenpox, insect bites and stings, heat rashes and personal itching.

    Treatment of scabies.

    Dosage

    Adults

    Pruritus
    Apply to the affected area two or three times daily.
    Each application should provide relief from itching for 6 to 10 hours.

    Scabies
    After the patient has taken a warm bath, the skin should be well dried and the crotamiton cream or emulsion rubbed into the entire body surface (excluding the face and scalp) until no traces of the preparation remain visible on the surface.

    The application should be repeated once daily, preferably in the evening, for a total of three to five days.

    Depending on response, special attention should be paid to sites that are particularly susceptible to infestation (wrists, interdigital spaces, axillae and genitalia).
    Areas where there is pus formation should be covered with a dressing impregnated with crotamiton.
    While the treatment is in progress the patient may take a bath shortly before the next application.
    Once treatment is complete, a cleansing bath should be taken followed by a change of bed linen and underclothing.

    Children

    Children aged 3 to 18 years
    Pruritus
    Apply to the affected area two or three times daily.

    Scabies
    The manufacturer suggests that crotamiton cream and emulsion can be used in children but does not specify a dose.

    Children aged under 3 years
    To be used under medical supervision.
    Pruritus
    Apply to the affected area once daily.

    Scabies
    Apply to the affected area once daily.

    Administration

    For topical administration

    Contraindications

    Acute exudative dermatoses

    Precautions and Warnings

    Consult doctor before use on children under 3 years - see Dosage: Children.

    Do not use in or around the eyes, on broken skin or for weeping skin conditions.

    Genital pruritus - consult doctor before use.

    Discontinue if hypersensitivity reactions occur.

    Pregnancy - see Pregnancy section .

    Breastfeeding - see Lactation section.

    Pregnancy and Lactation

    Pregnancy

    There is no experience to judge the safety of crotamiton in pregnancy, therefore manufacturer does not recommend its use during pregnancy, especially in the first 3 months.

    The use of all medication in pregnancy should be avoided whenever possible; particularly in the first trimester. Non-drug treatments should also be considered. When essential, a medication with the best safety record over time should be chosen, employing the lowest effective dose for the shortest possible time. Polypharmacy should be avoided. Teratogens taken in the pre-embryonic period, often quoted as lasting until 14-17 days post-conception, are believed to have an all-or-nothing effect. Where drugs have a short half-life, and when the date of conception is certain, this may allow women to be reassured where drug exposure has occurred within this time frame. Further advice may be available from the UK National Teratology Information Service (NTIS) and through ToxBase, available via password at ( https://www.toxbase.org/ ) or if this is unavailable at the backup site ( https://www.TOXBASEbackup.org/ ).

    Lactation

    It is not known whether the active substance passes into breast milk so caution in use is required.

    Nursing mothers should avoid application to the nipple area.

    Neonates, infants born prematurely, those with low birth weight, those with an unstable gastrointestinal function or who have serious illnesses may require special consideration. For any infant, if a drug is prescribed to the nursing mother, it should be at the lowest practical dose and for the shortest time. When drug administration is unavoidable and breastfeeding is to continue, minimisation of exposure of the infant to the drug may sometimes be achieved by timing the maternal doses to just after a feeding episode. Infants exposed to drugs via breast milk should be monitored for unusual signs or symptoms. Interactions between the drug received by the infant from the mother's milk and medication prescribed for the infant should also be considered, for example, when the drug given to the infant may prevent metabolism of the drug received via breast milk.
    Specialist advice is available from the UK Drugs in Lactation Advisory Service at https://www.midlandsmedicines.nhs.uk/content.asp?section=6&subsection=17&pageIdx=1

    Effects on Ability to Drive and Operate Machinery

    None known

    Counselling

    Patients should be advised to contact their doctor if symptoms persist.

    Side Effects

    Local irritation
    Contact allergy

    Overdosage

    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( https://www.toxbase.org/ ) or if this is unavailable at the backup site ( https://www.TOXBASEbackup.org/ ).

    Shelf Life and Storage

    Protect from heat

    Reference Sources

    Summary of Product Characteristics: Eurax Cream. Novartis Consumer Health. Revised April 2004.
    Summary of Product Characteristics: Eurax Lotion. Novartis Consumer Health. Revised November 2001.

    NICE Evidence Services Available at: www.nice.org.uk Last accessed: 06 September 2017

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