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Cyclizine lactate parenteral


Parenteral formulations of cyclizine lactate.

Drugs List

  • cyclizine 50mg/ml injection
  • Therapeutic Indications


    Labyrinthine disorders
    Motion sickness
    Nausea and vomiting associated with narcotic analgesics
    Nausea or vomiting associated with radiotherapy
    Pre-op. emergency surgery: Reduce regurgitation/aspiration gastric contents
    Prevention/treatment of post-operative nausea and vomiting



    50mg up to three times a day administered via the intravenous or intramuscular route.

    For the prevention of postoperative nausea and vomiting, the first dose should be administered by slow intravenous injection 20 minutes before the anticipated end of surgery.

    Before induction of anaesthesia in emergency surgery, cyclizine, given intravenously in half the normal recommended dose, increases lower oesophageal sphincter tone and thereby reduces the hazard of regurgitation and aspiration of gastric contents.


    By intravenous injection over 3 to 5 minutes (unlicensed)
    Children aged 12 to 18 years:50mg up to three times daily.
    Children aged 6 to 12 years:25mg up to three times daily.
    Children aged 1 month to 6 years:0.5mg/kg to 1mg/kg up to 3 times daily. Each dose should not exceed a maximum of 25mg.

    By continuous intravenous or subcutaneous infusion (unlicensed)
    Children aged 12 to 18 years:150mg over 24 hours.
    Children aged 6 to 12 years:75mg over 24 hours.
    Children aged 2 to 5 years:50mg over 24 hours.
    Children aged 1 month to 2 years: 3mg/kg over 24 hours.


    For intravenous and intramuscular injection only

    Cyclizine via the intravenous route is to be administered slowly into the blood stream, with only minimal withdrawal of blood into the syringe.



    Precautions and Warnings

    Children under 18 years
    Benign prostatic hyperplasia
    Epileptic disorder
    Gastrointestinal obstruction
    Hepatic disorder
    Myocardial infarction
    Neuromuscular disorder
    Pyloroduodenal obstruction
    Severe cardiac failure
    Urinary retention

    Advise ability to drive/operate machinery may be affected by side effects
    May precipitate glaucoma
    Potential for drug abuse
    May counteract the haemodynamic benefits of opioids
    Advise patient to avoid alcohol during treatment

    Intravenous cyclizine should be used with caution in all patients with underlying neuromuscular disorders since cases of transient paralysis have been reported.

    Cyclizine should be used with caution in patients with severe heart failure. In such patients, cyclizine may cause a fall in cardiac output associated with increases in heart rate, mean arterial pressure and pulmonary wedge pressure.

    Pregnancy and Lactation


    Use cyclizine with caution in breastfeeding.

    The manufacturer states that safety in pregnancy is not established and so not advised. Some animal studies are interpreted as indicating that cyclizine may be teratogenic. Though no increased malformations were observed when used in 111 human patients in the first trimester and no link to oral clefts has been found. A retrospective study found that significantly fewer infants with malformations were exposed to antihistamines/antiemetics in the first trimester compared with controls. Furthermore; a large meta-analysis of 24 studies using antihistamines with more than 200,000 participating women showed no risk of major malformations.

    Schaefer et al concludes that on the body of evidence, coupled with the fact that cyclizine has been on the market for a long time with no adverse effects reported on newborns, cyclizine is considered safe in human pregnancy.

    An association between retrolental fibroplasia in premature infants has been reported with the use of antihistamines in the last 2 weeks of the pregnancy.

    The use of all medication in pregnancy should be avoided whenever possible; particularly in the first trimester. Non-drug treatments should also be considered. When essential, a medication with the best safety record over time should be chosen, employing the lowest effective dose for the shortest possible time. Polypharmacy should be avoided. Teratogens taken in the pre-embryonic period, often quoted as lasting until 14 to 17 days post-conception, are believed to have an all-or-nothing effect. Where drugs have a short half-life, and when the date of conception is certain, this may allow women to be reassured where drug exposure has occurred within this time frame. Further advice may be available from the UK National Teratology Information Service (NTIS) and through ToxBase, available via password on the internet ( ) or if this is unavailable at the backup site ( ).


    Cyclizine is contraindicated in breastfeeding.

    It is not known whether cyclizine or its metabolites are excreted in human milk. At the time of writing, no reports have been located of its used during breastfeeding. Though Lactmed states that occasional doses of cyclizine are probably acceptable during breastfeeding. Large doses or more prolonged use may cause effects in the infant or decrease the milk supply.

    Neonates, infants born prematurely, those with low birth weight, those with an unstable gastrointestinal function or who have serious illnesses may require special consideration. For any infant, if a drug is prescribed to the nursing mother, it should be at the lowest practical dose and for the shortest time. When drug administration is unavoidable and breastfeeding is to continue, minimisation of exposure of the infant to the drug may sometimes be achieved by timing the maternal doses to just after a feeding episode. Infants exposed to drugs via breast milk should be monitored for unusual signs or symptoms. Interactions between the drug received by the infant from the mother's milk and medication prescribed for the infant should also be considered, for example, when the drug given to the infant may prevent metabolism of the drug received via breast milk.
    Specialist advice is available from the UK Drugs in Lactation Advisory Service at


    Side effects associated with cyclizine include hallucinations, drowsiness, sedation, confusion, disorientation and blurred vision. Patients suffering from these adverse affects should be advised not to drive or operate machinery.

    Patients should avoid alcohol as additive effects of drowsiness and poor co-ordination may occur.

    As an antiemetic, cyclizine also makes toxicity from alcohol more dangerous.

    Side Effects

    Allergic skin reactions
    Blood disorders
    Blurred vision
    Cholestatic hepatitis
    Cholestatic jaundice
    Dry mouth
    Dry throat
    Dryness of nose
    Erythema at injection site
    Extrapyramidal effects
    Fixed drug eruption
    Gastro-intestinal disturbances
    Glaucoma (closed angle)
    Hepatic impairment
    Hypersensitivity reactions
    Impaired consciousness
    Muscle spasm
    Oculogyric crisis
    Pain / soreness (injection site)
    Psychomotor impairment
    Sensation of heaviness
    Sleep disturbances
    Speech disturbances
    Thrombophlebitis (injection site)
    Urinary retention


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: November 2014

    Reference Sources

    Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment, 2nd edition (2007) ed. Schaefer, C., Peters, P. and Miller, R. Elsevier, London.

    Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 9th edition (2011) ed. Briggs, G., Freeman, R. and Yaffe, S. Lippincott Williams & Wilkins, Philadelphia.

    Medications and Mothers' Milk, 14th Edition (2010) Hale, T. Hale Publishing, Amarillo, Texas.

    Summary of Product Characteristics: Cyclizine lactate 50mg/ml injection . AMCo. Revised September 2013.

    Summary of Product Characteristics: Valoid injection. Amdipharm. Revised October 2009.

    US National Library of Medicine. Toxicology Data Network. Drugs and Lactation Database (LactMed).
    Available at:
    Cyclizine Last revised: 16 January 2014
    Last accessed: 26 November 2014

    NICE Evidence Services Available at: Last accessed: 17 August 2017

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