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Dexamethasone sodium phosphate oral

Updated 2 Feb 2023 | Glucocorticoid therapy


Oral formulations containing dexamethasone sodium phosphate.

Drugs List

  • dexamethasone 10mg soluble tablet sugar-free
  • dexamethasone 10mg/5ml oral solution sugar-free
  • dexamethasone 20mg soluble tablet sugar-free
  • dexamethasone 20mg/5ml oral solution sugar-free
  • dexamethasone 2mg soluble tablet sugar-free
  • dexamethasone 2mg/5ml oral solution sugar-free
  • dexamethasone 4mg soluble tablet sugar-free
  • dexamethasone 8mg soluble tablet sugar-free
  • DEXSOL 2mg/5ml oral solution
  • GLENSOLUDEX 2mg soluble tablet
  • GLENSOLUDEX 4mg soluble tablet
  • GLENSOLUDEX 8mg soluble tablet
  • Therapeutic Indications


    Adrenocortical insufficiency
    Chemotherapy induced nausea and vomiting
    Congenital adrenal hyperplasia
    Coronavirus disease 2019 (COVID-19) - treatment
    Croup (acute laryngotracheobronchitis)
    Diagnostic test for adrenocortical function
    Inflammatory or allergic conditions
    Palliative treatment of neoplastic disease
    Raised intracranial pressure secondary to cerebral tumour

    Endocrine disorders
    Primary or secondary adrenocortical insufficiency.
    Congenital adrenocortical hyperplasia.
    Endocrine exophthalmos.
    Diagnostic testing of adrenocortical hyperfunction.

    Non-endocrine disorders
    Dexamethasone has been used for suppression of inflammatory and allergic disorders in the treatment of a range of non-endocrine corticosteroid responsive conditions.

    Allergy and anaphylaxis

    Arteritis collagenosis
    Polymyalgia rheumatica, active phases of systemic vasculitides like panarteritis nodosa (if concomitant positive hepatitis B serology the treatment should be limited to two weeks)

    Haematological disorders
    Haemolytic anaemia (also autoimmune), leukaemia, myeloma, idiopathic thrombocytopenic purpura in adults, reticulolymphoproliferative disorders.

    Tuberculosis meningitis only in conjunction with anti-infective therapy.

    Gastroenterological disorders
    For treatment in the critical stage in: ulcerative colitis (rectal only); Crohn's disease; certain forms of hepatitis.

    Muscular disorders

    Neurological disorders
    Raised intracranial pressure secondary to cerebral tumours, acute exacerbations of multiple sclerosis, cerebral oedema caused by a brain tumour, neuro-surgical intervention or cerebral abscess.

    Ocular disorders
    Anterior and posterior uveitis, optic neuritis, chorioretinitis, iridocyclitis, temporal arteritis, orbital pseudotumour.

    Renal disorders
    Nephrotic syndrome.

    Pulmonary disorders
    Chronic bronchial asthma, acute asthma, aspiration pneumonitis, chronic obstructive pulmonary disease (COPD), sarcoidosis, allergic pulmonary disease such as farmer's and pigeon breeder's lung, Loffler's syndrome, cryptogenic fibrosing alveolitis, croup.

    Rheumatic disorders
    Some cases or specific forms (Felty's syndrome, Sjorgen's syndrome) of rheumatoid arthritis, including juvenile rheumatoid arthritis, acute rheumatism, temporal arteritis (polymyalgia rheumatica), systemic lupus erythematosus, active rheumatoid arthritis.

    Skin disorders
    Pemphigus vulgaris, bullous pemphigoid, erythrodermas, serious forms of erythema multiforme (Stevens-Johnson syndrome), mycosis fungoides, bullous dermatitis herpetiformis.

    Oncological disorders
    Acute lymphocytic leukemia, acute lymphoblastic leukemia, malignant lymphoma (Hodgkin's disease, non-Hodgkin's lymphoma), metastasized breast cancer, hypercalcaemia as a result of bone metastasis or Kahler's disease, palliative treatment of neoplastic diseases, metastatic spinal cord compression.

    Coronavirus disease 2019 (COVID-19)
    Treatment of COVID-19 in adult and adolescent patients who require supplemental oxygen therapy.

    Intense allergic reactions; as immunosuppressants in organ transplantation; as an adjuvant in the prevention of nausea and vomiting and in the treatment of cancer with oncolytics that have a serious emetic effect; as an adjuvant in the treatment and prevention of postoperative vomiting.


    Individualise the dosage on the basis of the disease and the response of the patient. To minimise the risk of any side effects always use the lowest possible dosage adequate to control the disease process.


    The initial dosage varies from 500 micrograms to 10mg daily depending on the disease being treated. In more severe diseases, higher dosages may be temporarily required to control the disease. Once the disease is under control the dosage should be reduced or tapered off to the lowest suitable level under continuous monitoring and observation of the patient.

    Chronic dosage should preferably not exceed 1.5mg dexamethasone daily.

    Both the evening dose (which is useful in alleviating morning stiffness in some conditions), and the divided dosage regimen are associated with greater suppression of the hypothalamus-pituitary-adrenal axis.

    If satisfactory clinical response does not occur after a reasonable period of time, discontinue treatment and transfer the patient to other therapy.

    In acute, self-limiting allergic disorders or acute exacerbations of chronic allergic disorders, the following dosage schedule combining parenteral and oral therapy is suggested:

    First day: dexamethasone injection 4mg to 8mg intramuscularly.

    Second day: 1mg dexamethasone twice daily.

    Third day: 1mg dexamethasone twice daily.

    Fourth day: 500 micrograms dexamethasone twice daily.

    Fifth day: 500 micrograms dexamethasone twice daily.

    Sixth day: 500 micrograms dexamethasone once daily.

    Seventh day: 500 micrograms dexamethasone once daily.

    Eighth day: Re-assessment

    Dexamethasone suppression tests:

    Test for Cushing's syndrome:
    1mg to 2mg dexamethasone should be administered orally at 11 pm. Blood samples are then taken at 8 am the following morning for plasma cortisol determination. For greater accuracy, 500micrograms dexamethasone should be administered every 6 hours for 48 hours. Blood samples should be drawn at 8 am on the third morning for plasma cortisol determination. 24-hour urine collections should be employed for determination of 17-hydroxycorticosteroid excretion.

    Test to distinguish Cushing's syndrome caused by pituitary ACTH excess from the syndrome induced by other causes:
    2mg dexamethasone administered orally every 6 hours for 48 hours. Blood should be drawn at 8 am on the third morning for plasma cortisol measurement. 24-hour urine collections should be employed for determination of 17-hydroxycorticosteroid excretion.

    Chemotherapy induced nausea and vomiting
    Prevention of acute symptoms: 4mg to 20mg immediately before chemotherapy
    Prevention of delayed symptoms: 8mg twice daily for two to four days or 4mg to 16mg daily on day 2 and 3.

    Raised intracranial pressure
    Initial therapy is usually given by injection. Maintenance oral dose 2mg two to three times a day may be effective. Depending on the cause and severity, 2mg to 4mg three to four times daily may be necessary (up to 24mg daily dose).

    Acute asthma: 16mg daily for 2 days.

    Acute skin diseases
    8mg to 40mg daily depending on severity, in some cases up to 100mg may be required, which should be followed by down titration according to clinical need.

    300mg for three days followed by down titration according to clinical need.

    40mg for four days in cycles.

    Systemic lupus erythematosus: 6mg to 16mg daily.

    Active rheumatoid arthritis
    Fast destructive forms: 12mg to 16mg daily.
    Extra-articular manifestations: 6mg to 12mg daily.

    Idiopathic thrombocytopenia purpura: 40mg for four days in cycles.

    Tuberculosis meningitis
    Grade 2 or 3
    Week 1: 400micrograms per kg per day intravenously.
    Week 2: 300micrograms per kg per day intravenously.
    Week 3: 200micrograms per kg per day intravenously.
    Week 4: 100micrograms per kg per day intravenously.
    Week 5: 4mg per day orally.
    Week 6: 3mg per day orally.
    Week 7: 2mg per day orally.
    Week 8: 1mg per day orally.

    Grade 1
    Week 1: 300micrograms per kg per day intravenously.
    Week 2: 200micrograms per kg per day intravenously.
    Week 3: 100micrograms per kg per day orally.
    Week 4: 3mg per day orally.
    Week 5: 2mg per day orally.
    Week 6: 1mg per day orally.

    Palliative treatment of neoplastic diseases
    3mg to 20mg per day, depending on the cause and severity. Very high doses up to 96mg may also be used for palliative care.

    The following doses may be suitable:

    Symptom control of anorexia in palliative care
    2mg to 4mg daily.

    Dysphagia due to obstruction by tumour in palliative care
    8mg daily.

    Dyspnoea due to bronchospasm or partial obstruction in palliative care
    4mg to 8mg daily.

    Adjunct in the treatment of nausea and vomiting in palliative care
    8mg to 16mg daily.

    Headaches due to raised intracranial pressure in palliative care
    16mg daily for 4 to 5 days, then reduce to 4mg to 6mg daily. Reduce dose further if possible. To reduce the risk of insomnia dexamethasone should be given before 6pm.

    Pain due to nerve compression in palliative care
    8mg daily.

    Cerebral oedema associated with brain tumours
    0.5mg to 10mg daily.

    Prevention and treatment of post-operative vomiting, within antiemetic treatment
    Single dose of 8mg before surgery.

    Symptomatic treatment of multiple myeloma, acute lymphocytic leukaemia, acute lymphoblastic leukaemia, Hodgkin's disease and non-Hodgkin's lymphoma in combination with other medicinal products
    Usually 40mg to 20mg daily.
    Consult the product literature for the co-administered medicinal product for suggested dexamethasone dosage regimens. Local or international protocols should be followed where appropriate.

    Coronavirus disease 2019: 6mg once daily for up to 10 days.

    Cerebral oedema:
    6mg to 16mg (up to 24mg) daily divided into 3 to 4 individual doses.


    10 micrograms to 100 micrograms per kg bodyweight daily.

    Children on prolonged therapy should be carefully monitored. The optimal dosage will depend on body weight and clinical condition being treated.

    Single dose of 150 micrograms/kg. A second dose may be administered after 12 hours if required.
    Some manufacturers recommend a single dose of 150 micrograms/kg to 600 micrograms/kg, and repeat after 12 hours if required.
    The following alternative dosing schedule may also be suitable:
    150 microgram/kg initially, to be given before arriving to hospital. Then a dose of 150 micrograms/kg and another 150 microgram/kg after 12 hours if required.

    Acute asthma
    0.6mg per kg body weight for one or two days.

    Dosage should be limited to a single dose on alternate days to lessen risk of growth retardation and minimise suppression of hypothalamo-pituitary-adrenal axis.

    Coronavirus disease 2019
    Children aged 12 to 18 years old weighing at least 40kg
    6mg once daily for up to 10 days.

    The following alternative dosing schedule may be suitable:

    For inflammatory and allergic disorders
    10 micrograms/kg to 100 micrograms/kg bodyweight daily in 1 to 2 divided doses, adjusted according to response. Up to 300 micrograms/kg bodyweight daily may be required in emergency situations.

    For physiological replacement
    250 micrograms to 500 micrograms per square metre every 12 hours, adjusted according to response.

    Coronavirus disease 2019
    Children aged 1 month to 18 years (unlicensed)
    150 micrograms/kg once daily for 10 days. Maximum 6mg once daily.

    Additional Dosage Information

    Using the lowest effective dose for a minimum period and where appropriate administering the daily requirement as a single morning dose minimises undesirable effects.

    The following equivalents facilitate changing to dexamethasone from other glucocorticoids:
    Milligram for milligram:
    dexamethasone is approximately equivalent to betamethasone.
    4 to 6 times more potent than methylprednisolone and triamcinolone.
    6 to 8 times more potent than prednisone and prednisolone.
    25 to 30 times more potent than hydrocortisone, and
    about 35 times more potent than cortisone.

    Withdrawing therapy
    Patients receiving doses greater than approximately 1mg of dexamethasone daily (approximately normal physiological levels) for more than 3 weeks should be withdrawn gradually. Reduction method will depend on the likelihood of disease relapse during dose reduction. Clinical assessment of disease activity may be required during withdrawal. If relapse is unlikely but there is uncertainty about HPA suppression, the dose may be reduced rapidly to 1mg dexamethasone and then reduced more slowly to allow HPA-axis recovery.

    If the relapse is unlikely and up to 6mg dexamethasone has been given for less than 3 weeks then abrupt withdrawal is unlikely to result in clinically relevant HPA-axis suppression in the majority of patients.

    Even after less than 3 weeks treatment, gradual withdrawal should be considered in the following patient groups:
    Patients who have had repeated systemic steroid courses especially if courses were for longer than 3 weeks.
    When a short course has been prescribed within one year of stopping a course that had lasted for months or years.
    Patients at risk of adrenocortical insufficiency other than exogenous corticosteroid therapy.
    Patients receiving doses greater than 6mg daily of dexamethasone.
    Patients repeatedly taking doses in the evenings.


    The soluble tablet is not suitable for subdivision of dose either as a tablet or solution.

    Soluble tablets should preferably be dissolved in half a small glass of water and the solution drunk immediately after dissolution. A minimum volume of approximately 50 ml of water is sufficient for complete dissolution.


    Uncontrolled systemic infection

    Precautions and Warnings

    Children under 18 years
    Family history of diabetes mellitus
    Family history of glaucoma
    Congestive cardiac failure
    Corneal damage
    Diabetes mellitus
    Epileptic disorder
    Gastrointestinal anastomosis
    Gastrointestinal ulcer
    Hepatic cirrhosis
    Hepatic impairment
    Hereditary fructose intolerance
    History of severe affective disorders
    History of steroid myopathy
    History of steroid-induced psychosis
    History of tuberculosis
    Myasthenia gravis
    Ocular herpes simplex infection
    Peptic ulcer
    Recent myocardial infarction
    Renal impairment
    Severe affective disorders
    Thromboembolic disorder
    Ulcerative colitis

    Administration of live vaccines is not recommended
    Consider increased dose during intercurrent illness/trauma/surgery
    Consider reintroducing steroids temporarily during illness/trauma/surgery
    Disease reactivation may occur in patients with latent TB
    Exposure to measles may require prophylaxis with normal immunoglobulin
    May activate latent amoebiasis
    May mask symptoms or signs of infections
    Patients with diabetes may experience fluctuations in blood glucose
    Sodium content of effervescent preparation may be significant
    Advise ability to drive/operate machinery may be affected by side effects
    Not all available brands are licensed for all indications
    Passive immunisation of chicken pox / herpes zoster may be required
    May contain sodium benzoate: may increase risk of jaundice in neonates
    Oral solution with maltitol unsuitable in hereditary fructose intolerance
    Presentations with sorbitol unsuitable in hereditary fructose intolerance
    Some brands contain Sunset Yellow (E110) - can trigger allergic reactions
    Ensure patient's dietary intake of calcium and vitamin D is adequate
    Frequent review needed to titrate dose to disease activity
    If visual disturbances occur, perform ophthalmic evaluation
    Monitor blood pressure regularly
    Monitor patients at risk of tumour lysis syndrome
    Monitor regularly the height of children receiving prolonged treatment
    Pregnancy: Monitor closely patients with pre-eclampsia or fluid retention
    Prolonged or high dose may lead to adrenal suppression
    Psychological changes may occur during initiation & withdrawal of treatment
    Supervise patient closely during drug withdrawal
    Adrenal cortical atrophy may persist for years after stopping drug
    Antibody response to vaccines may be reduced
    Corticosteroids may cause growth retardation in children under 18 years
    May cause activation of latent psychosis
    May cause posterior subcapsular cataracts and glaucoma in long term use
    Oversuppression of immune system may increase susceptibility to infection
    Patient should report worrying psychological changes esp. suicidal thoughts
    Potassium supplements may be required
    May affect results of some laboratory tests
    Sudden withdrawal may be inadvisable -see product information/SPC
    Maintain treatment at the lowest effective dose
    Advise patient not to take St John's wort concurrently
    Dietary salt restriction may be necessary
    Advise patient to avoid exposure to measles
    Advise patient to seek urgent medical attention if exposed to measles
    Advise those on systemic corticosteroids to avoid chickenpox/H zoster
    Ensure patient receives Steroid Treatment/Steroid Emergency Card
    If exposed to chickenpox or Herpes zoster seek urgent medical attention

    Patients (or parents of children) without a definite history of chicken pox should be advised to avoid close personal contact with chicken pox or herpes zoster and seek urgent medical attention if exposed as chicken pox can prove fatal in immunocompromised patients. If exposed while on dexamethasone or within three months of previous use, passive immunisation with varicella/zoster immunoglobulin (VZIG) should be administered within 10 days of the exposure. If chicken pox occurs, treat urgently under specialist care. Do not stop dexamethasone therapy, an upwards dosage adjustment may be required.
    Treatment of elderly patients, particularly if long term, should be planned bearing in mind the more serious consequences of the common side effects of corticosteroids in old age, especially osteoporosis, diabetes, hypertension, hypokalaemia, susceptibility to infection and thinning of the skin. Close clinical supervision is required especially during long term therapy.

    Corticosteroids should not be used for the treatment of cerebral oedema associated with cerebrovascular accident or head injury, as they are unlikely to be of benefit and may cause harm.

    Phaeochromocytoma crisis has been reported following administration of systemic corticosteroids, patients with suspected phaeochromocytoma should be evaluated before corticosteroids administration.

    For long-term treatment, after initial therapy, it is advisable to switch dexamethasone to prednisolone or prednisone to reduce suppression of the function of the adrenal cortex.

    Pregnancy and Lactation


    Use dexamethasone with caution during pregnancy.

    The manufacturer advises that dexamethasone sodium phosphate is used only if the benefits to the mother outweigh the potential risk to the foetus. However, if corticosteroids are considered essential, patients with normal pregnancies may be treated as though they were in the non-gravid state. Animal studies have shown that treatment during pregnancy using dexamethasone have caused foetal abnormalities such as cleft palate, intrauterine growth retardation and effects on brain growth and development.

    Dexamethasone readily crosses the placenta, foetal serum concentrations are similar to maternal concentrations. Administration for prolonged periods or repeatedly during pregnancy may increase the risk of intrauterine growth retardation. Hypoadrenalism may occur in the neonate following prenatal exposure to corticosteroids. However this will usually resolve following birth and is rarely clinically significant. Monitor infants born to mothers who have received substantial doses of corticosteroids during pregnancy for signs of hypoadrenalism.

    Patients with pre-eclampsia or fluid retention should be closely monitored. High doses in weeks 8 to 11, may warrant an ultrasonographic evaluation for cleft palate or cleft lip.


    Use dexamethasone with caution during breastfeeding.

    The manufacturer advises that a decision on whether to discontinue breastfeeding or treatment with dexamethasone should be made taking into account the benefit of breastfeeding to the child and dexamethasone to the woman. Corticosteroids are excreted into breast milk and may interfere with endogenous corticosteroid production and cause other undesirable effects. Infants of mothers receiving prolonged high dose corticosteroid therapy may experience a degree of adrenal suppression.

    Schaefer (2015) states that repeated high doses may warrant withholding from breastfeeding for 3 to 4 hours from last dexamethasone dose.

    Side Effects

    Abdominal distension
    Acute pancreatitis
    Aggravation of schizophrenia
    Allergic dermatitis
    Altered serum lipid profile
    Angioneurotic oedema
    Aseptic necrosis
    Avascular osteonecrosis
    Behavioural disturbances
    Blood disorders
    Bowel perforation
    Cognitive impairment
    Congestive cardiac failure
    Corneal thinning
    Cushingoid changes
    Emotional lability
    Exacerbation of epilepsy
    Exacerbation of ophthalmic fungal disease
    Exacerbation of ophthalmic viral disease
    Hair thinning
    Hypersensitivity reactions
    Hypokalaemic alkalosis
    Impaired carbohydrate tolerance, increased need for anti-diabetic therapy
    Increased appetite
    Increased calcium excretion
    Increased intra-ocular pressure
    Increased susceptibility to infection
    Increased sweating
    Interference with spermatogenesis
    Irregular menstruation
    Muscle weakness
    Myocardial rupture following recent myocardial infarction
    Negative calcium balance
    Negative protein balance
    Opportunistic infections
    Peptic ulceration with perforation and haemorrhage
    Posterior subcapsular cataracts
    Premature closure of epiphyses
    Proximal myopathy
    Pseudotumour cerebri
    Psychiatric disorders
    Psychological dependence
    Psychotic reactions
    Raised intracranial pressure
    Recurrence of dormant tuberculosis
    Reduced muscle mass
    Scleral thinning
    Secondary adrenocortical and pituitary unresponsiveness
    Sleep disturbances
    Sodium/water retention
    Suicidal tendencies
    Suppression of growth in children and adolescents
    Suppression of reactions to skin tests
    Suppression of the hypothalamic-pituitary-adrenal axis
    Tendon rupture
    Thinning of skin
    Tumour lysis syndrome
    Ulcerative oesophagitis
    Vertebral and long bone fractures
    Weight gain
    Withdrawal syndrome - see product information
    Wound healing retarded

    Effects on Laboratory Tests

    False negative results may occur with the nitroblue tetrazolium test for bacterial infection.

    May suppress skin reaction to allergy testing.

    Withdrawal Symptoms and Signs

    Too rapid a reduction of corticosteroid dosage following prolonged treatment can lead to acute adrenal insufficiency, hypotension and death. A 'withdrawal syndrome' may also occur including fever, myalgia, arthralgia, rhinitis, conjunctivitis, painful itchy skin nodules and weight loss.


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: October 2020

    Reference Sources

    Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment, 3rd edition (2015) ed. Schaefer, C., Peters, P. and Miller, R. Elsevier, London.

    Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 10th edition (2015) ed. Briggs, G., Freeman, R. Wolters Kluwer Health, Philadelphia.

    Summary of Product Characteristics: Dexamethasone 10mg/5ml Oral Solution. Rosemont. Revised March 2018.

    Summary of Product Characteristics: Dexsol 2mg/5ml Oral Solution. Rosemont. Revised January 2019.

    Summary of Product Characteristics: Martapan 2mg/5ml Oral Solution. Martindale Pharmaceuticals Ltd. Revised May 2018.

    Summary of Product Characteristics: Dexamethasone 2mg soluble tablets. Glenmark Generics (Europe) Ltd. Revised November 2015.
    Summary of Product Characteristics: Dexamethasone 4mg soluble tablets. Glenmark Generics (Europe) Ltd. Revised November 2015.
    Summary of Product Characteristics: Dexamethasone 8mg soluble tablets. Glenmark Generics (Europe) Ltd. Revised November 2015.

    Summary of Product Characteristics: Glensoludex 2 mg soluble tablets. Glenmark Pharmaceuticals Europe Ltd. Revised December 2020.
    Summary of Product Characteristics: Glensoludex 4 mg soluble tablets. Glenmark Pharmaceuticals Europe Ltd. Revised December 2020.
    Summary of Product Characteristics: Glensoludex 8 mg soluble tablets. Glenmark Pharmaceuticals Europe Ltd. Revised December 2020.

    Summary of Product Characteristics: Dexamethasone 10mg soluble tablets. Aspire Pharma Limited. Revised October 2021.
    Summary of Product Characteristics: Dexamethasone 20mg soluble tablets. Aspire Pharma Limited. Revised October 2021.

    Summary of Product Characteristics: Dexamethasone 10mg soluble tablets. Wockhardt UK Limited. Revised December 2020.

    NICE Evidence Services Available at: Last accessed: 27 October 2022

    US National Library of Medicine. Toxicology Data Network. Drugs and Lactation Database (LactMed).
    Available at:
    Dexamethasone. Last revised: 15 November 2021
    Last accessed: 22 February 2022

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