Drugs List

Therapeutic Indications

Uses

Relief of pain and inflammation due to trauma

Contraindications

Administration site infection
Children under 14 years
Occlusive dressings
Open wounds
Nasal polyps, angioedema, and bronchospastic reactivity to NSAIDs
Third trimester of pregnancy

Precautions and Warnings

Allergic disposition
Haemorrhagic diathesis
Asthma
Breastfeeding
First trimester of pregnancy
Hepatic impairment
History of asthma
History of peptic ulcer
Inflammatory bowel disease
Renal impairment
Second trimester of pregnancy

NSAIDs may provoke or exacerbate asthma
Contains propylene glycol: may cause irritation
Some preps contain methyl & propylparaben; may cause allergic reactions
Some products may contain soya or soya derivative
Advise patient to wash hands after use
Avoid contact with diseased or inflamed skin
Avoid contact with eyes
Avoid contact with mucous membranes
Breastfeeding: Wash product off breasts prior to breastfeeding infant
For topical use only
Prolonged use over a large area may cause systemic absorption
Discontinue if patient is attempting to conceive
Discontinue treatment if rash occurs
Advise patient to minimise exposure of treated areas to sunlight/sunlamps
Discontinue and consult a doctor if there is no improvement within 3 days

Serious skin reactions, including exfoliative dermatitis, Stevens Johnson syndrome and epidermal necrolysis have been associated with the administration of NSAIDs. The risk of occurrence is highest during the first month of treatment. Concomitant use of oral NSAID's should be cautioned.

Pregnancy and Lactation

Pregnancy

Diclofenac sodium is contraindicated during pregnancy.

The manufacturer does not recommend using diclofenac sodium during the first and second trimesters of pregnancy unless clearly necessary. The dose should be low and the duration as short as possible.

Use of diclofenac sodium during the third trimester of pregnancy is contraindicated by the manufacturer. There is an increased risk of developmental effects including cardiopulmonary toxicity and renal dysfunction.

Lactation

Use diclofenac sodium with caution during breastfeeding.

The manufacturer does not recommend breastfeeding whilst using diclofenac sodium unless advised by a healthcare professional. Avoid application to the breast area.

Side Effects

Abdominal pain
Angioedema
Application site reaction
Asthma
Bronchospasm
Burning sensation (local)
Contact dermatitis
Dry skin
Dyspepsia
Eczema
Erythema
Gastrointestinal disorder
Hypersensitivity reactions
Photosensitivity
Pruritus
Rash
Renal disorders
Skin disorder
Skin reddening
Urticaria

Presentation

Gel formulation of diclofenac.

Drugs List

Therapeutic Indications

Uses

Relief of pain and inflammation due to trauma

Dosage

Adults

Elderly

Adolescents

Contraindications

Administration site infection
Children under 14 years
Occlusive dressings
Open wounds
Nasal polyps, angioedema, and bronchospastic reactivity to NSAIDs
Third trimester of pregnancy

Precautions and Warnings

Allergic disposition
Haemorrhagic diathesis
Asthma
Breastfeeding
First trimester of pregnancy
Hepatic impairment
History of asthma
History of peptic ulcer
Inflammatory bowel disease
Renal impairment
Second trimester of pregnancy

NSAIDs may provoke or exacerbate asthma
Contains propylene glycol: may cause irritation
Some preps contain methyl & propylparaben; may cause allergic reactions
Some products may contain soya or soya derivative
Advise patient to wash hands after use
Avoid contact with diseased or inflamed skin
Avoid contact with eyes
Avoid contact with mucous membranes
Breastfeeding: Wash product off breasts prior to breastfeeding infant
For topical use only
Prolonged use over a large area may cause systemic absorption
Discontinue if patient is attempting to conceive
Discontinue treatment if rash occurs
Advise patient to minimise exposure of treated areas to sunlight/sunlamps
Discontinue and consult a doctor if there is no improvement within 3 days

Serious skin reactions, including exfoliative dermatitis, Stevens Johnson syndrome and epidermal necrolysis have been associated with the administration of NSAIDs. The risk of occurrence is highest during the first month of treatment. Concomitant use of oral NSAID's should be cautioned.

Pregnancy and Lactation

Pregnancy

Diclofenac sodium is contraindicated during pregnancy.

The manufacturer does not recommend using diclofenac sodium during the first and second trimesters of pregnancy unless clearly necessary. The dose should be low and the duration as short as possible.

Use of diclofenac sodium during the third trimester of pregnancy is contraindicated by the manufacturer. There is an increased risk of developmental effects including cardiopulmonary toxicity and renal dysfunction.

Lactation

Use diclofenac sodium with caution during breastfeeding.

The manufacturer does not recommend breastfeeding whilst using diclofenac sodium unless advised by a healthcare professional. Avoid application to the breast area.

Side Effects

Abdominal pain
Angioedema
Application site reaction
Asthma
Bronchospasm
Burning sensation (local)
Contact dermatitis
Dry skin
Dyspepsia
Eczema
Erythema
Gastrointestinal disorder
Hypersensitivity reactions
Photosensitivity
Pruritus
Rash
Renal disorders
Skin disorder
Skin reddening
Urticaria

Overdosage

It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

The following number will direct the caller to the relevant local centre (0844) 892 0111

Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ).

Further Information

Last Full Review Date: November 2019

Reference Sources

Summary of Product Characteristics: Diclofenac 1% Gel. Typharm Ltd. Revised November 2019.