Dicycloverine hydrochloride oral
- Drugs List
- Therapeutic Indications
- Dosage
- Contraindications
- Precautions and Warnings
- Pregnancy and Lactation
- Side Effects
- Monograph
Presentation
Oral formulations of dicycloverine hydrochloride.
Drugs List
Therapeutic Indications
Uses
Adjunct in gastric smooth muscle spasm
Dosage
Adults
10 to 20mg three times per day.
Children
Dicycloverine is contraindicated in infants under 6 months of age.
Children aged 12 to 18 years
10 to 20mg three times per day.
Children aged 2 to 12 years
10mg three times per day.
Children aged 6 months to 2 years
5 to 10mg three to four times per day.
Give 15 minutes before feeds. Maximum daily dose of 40mg.
Contraindications
Children under 6 months
Myasthenia gravis
Paralytic ileus
Pyloric stenosis
Toxic megacolon
Precautions and Warnings
Diarrhoea
Down's syndrome
Elderly
Predisposition to narrow angle glaucoma
Pyrexia
Autonomic neuropathy
Benign prostatic hyperplasia
Breastfeeding
Cardiac impairment
Cardiac surgery
Galactosaemia
Glucose-galactose malabsorption syndrome
Hereditary fructose intolerance
Hiatus hernia
Hypertension
Hyperthyroidism
Lactose intolerance
Myocardial infarction
Narrow angle glaucoma
Pregnancy
Reflux oesophagitis
Tachycardia
Ulcerative colitis
Some formulations contain glucose
Some formulations contain lactose
Some formulations contain sucrose
Pregnancy and Lactation
Pregnancy
Use dicycloverine with caution during pregnancy.
The manufacturer recommends that dicycloverine is not used in pregnancy unless the potential benefit to the mother outweighs the potential risk to the foetus. Animal studies have demonstrated no evidence of impaired fertility or adverse foetal effects with dicycloverine. Epidemiological studies on the use of dicycloverine in human pregnancies have also indicated that dicycloverine hydrochloride does not appear to increase the risk of foetal abnormalities if administered during the first trimester of pregnancy.
Lactation
Use dicycloverine with caution during breastfeeding.
The manufacturer recommends that caution is exercised when dicycloverine is administered during breastfeeding and state that it is unknown whether dicycloverine is secreted in human milk.
Side Effects
Anorexia
Arrhythmias
Blurred vision
Bradycardia
Confusion
Constipation
Decreased bronchial secretions
Difficulty in micturition
Dilatation of pupils
Disturbances in accommodation
Dizziness
Dry mouth
Dry skin
Dysuria
Fatigue
Flushing
Giddiness
Glaucoma (closed angle)
Headache
Nausea
Palpitations
Photophobia
Rash
Sedation
Tachycardia
Thirst
Urinary retention
Urinary urgency
Vomiting
Overdosage
It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.
The following number will direct the caller to the relevant local centre (0844) 892 0111
Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ).
Further Information
Last Full Review Date: August 2014
Reference Sources
Summary of Product Characteristics: Dicycloverine 10mg tablets. Zentiva. Revised April 2014.
Summary of Product Characteristics: Dicycloverine 10mg/5ml oral solution. Zentiva. Revised May 2014.
Summary of Product Characteristics: Dicycloverine 20mg tablets. Zentiva. Revised April 2014.
Summary of Product Characteristics: Dicycloverine Hydrochloride 10mg/5ml Oral Solution. Noumed Life Sciences Limited. Revised October 2019.
NICE Evidence Services Available at: www.nice.org.uk Last accessed: 08 September 2022
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