This site is intended for UK healthcare professionals
Medscape UK Univadis Logo
Medscape UK Univadis Logo

Fluocinolone acetonide implant intravitreal


Intravitreal implant containing fluocinolone acetonide.

Drugs List

  • fluocinolone acetonide 190microgram intravitreal implant in applicator
  • ILUVIEN 190microgram intravitreal implant in applicator
  • Therapeutic Indications


    Posterior segment non-infectious uveitis
    Treatment of visual impairment due to diabetic macular oedema

    Treatment of vision impairment associated with chronic diabetic macular oedema insufficiently responsive to available therapies.

    Prevention of relapse in recurrent posterior segment non-infectious uveitis.



    Diabetic macular oedema
    One implant to be administered intravitreally to the affected eye.
    An additional implant may be administered after 12 months if the patient experiences decreased vision or an increase in retinal thickness secondary to recurrent or worsening diabetic macular oedema.

    Posterior segment non-infectious uveitis
    One implant to be administered intravitreally to the affected eye.
    Retreatment with an additional implant is currently not supported by the available data.


    Children under 18 years
    Ocular infection
    Periocular infection

    Precautions and Warnings

    Raised intra-ocular pressure

    Advise visual disturbances may affect ability to drive or operate machinery
    Consider premedication with antibiotic eye drops
    Exclude infectious uveitis before treatment
    Exclude ocular or periocular infection prior to treatment
    Treatment to be administered under the supervision of a specialist
    Check ocular lens frequently - risk of cataract formation
    Consider implant migration to anterior chamber if visual disturbance occurs
    Monitor for ocular complications 2 to 8 days following administration
    Monitor IOP 2 to 8 days after injection and at least quarterly thereafter
    Advise patient to report any symptoms of endophthalmitis immediately
    Advise patient to report any unexpected changes in eye symptoms immediately
    Consider removing implant by vitrectomy if IOP cannot be controlled

    Pregnancy and Lactation


    Fluocinolone acetonide intravitreal implant is contraindicated during pregnancy.
    Manufacturer recommends to avoid its use during pregnancy.
    There is limited data regarding the use of fluocinolone acetonide administered intravitreally. Fluocinolone is a potent corticosteroid and low levels of systemic exposure can present risk to the foetus.


    Fluocinolone acetonide intravitreal implant is contraindicated during breastfeeding.
    Manufacturer states that a decision must be made whether to discontinue breastfeeding or to abstain from the treatment.
    No data is available regarding the use of fluocinolone acetonide intravitreal implant during breastfeeding. Fluocinolone is know to be excreted in breast milk when used systemically.

    Side Effects

    Blurred vision
    Cells in anterior chamber of eye
    Choroidal detachment
    Conjunctival haemorrhage
    Conjunctival ulcer
    Corneal deposits
    Corneal erosion
    Dry eyes
    Extrusion of implant
    Eye swelling
    Implant migration
    Increased intra-ocular pressure
    Increased susceptibility to infection
    Iris adhesion
    Iris neovascularisation
    Macular fibrosis
    Ocular discharge
    Ocular hyperaemia
    Ocular hypotony
    Ocular pain
    Ocular pruritus
    Optic atrophy
    Optic disc haemorrhage
    Posterior capsule opacification
    Procedural pain
    Reduced visual acuity
    Retinal detachment
    Retinal exudates
    Retinal or optic nerve changes
    Scleral thinning
    Sensation of foreign body in eye
    Visual field defects
    Vitreous detachment
    Vitreous disorder
    Vitreous haemorrhage

    Further Information

    Last Full Review Date: April 2019

    Reference Sources

    Summary of Product Characteristics: Iluvien 190 micrograms intravitreal implant in applicator. Alimera Sciences Limited. Revised March 2019.

    Access the full UK drug database with a FREE Medscape UK Account
    It takes just a few minutes, and you’ll get unlimited access to information on over 11,000 UK drugs.
    Register for Free

    Already a member? Log in

    Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content

    FDB Logo

    FDB Disclaimer : FDB Multilex is intended for the use of healthcare professionals and is provided on the basis that the healthcare professionals will retain FULL and SOLE responsibility for deciding what treatment to prescribe or dispense for any particular patient or circumstance.