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Fusidic acid oral

Updated 2 Feb 2023 | Fusidic acid


Oral formulation of fusidic acid

Drugs List

  • FUCIDIN 250mg/5ml suspension
  • fusidic acid 250mg/5ml suspension
  • Therapeutic Indications


    Treatment of staphylococcal infections

    Treatment of all staphylococcal infections due to susceptible organisms such as; cutaneous infections, osteomyelitis, pneumonia, septicaemia, wound infections, endocarditis, superinfected cystic fibrosis.



    750mg three times daily.


    Children aged 5 to 12 years: 500mg three times daily.
    Children aged 1 to 5 years: 250mg three times daily.
    Children aged 0 to 1 years: 50mg/kg daily, divided into three equal doses.


    50mg/kg daily, divided into three equal doses.


    Hereditary fructose intolerance

    Precautions and Warnings

    Biliary obstruction
    Biliary tract disorder
    Glucose-galactose malabsorption syndrome
    Hepatic impairment

    Contains more than 1 mmol (23 mg) sodium per dose
    Consult national/regional policy on the use of anti-infectives
    Contains benzyl alcohol
    Contains glucose
    Presentations with sorbitol unsuitable in hereditary fructose intolerance
    Monitor hepatic function in patients on high oral doses
    Monitor hepatic function on long term therapy
    Discontinue therapy if jaundice develops and persists

    Bacterial resistance has been reported to occur with the use of fusidic acid. As with all antibiotics, extended or recurrent use may increase the risk of developing resistance.

    Pregnancy and Lactation


    Fusidic acid should be used with caution in pregnancy.

    Fusidic acid may only be used during pregnancy if the potential benefits outweigh the potential risks to the foetus.

    At the time of writing there was inadequate evidence regarding use during human pregnancy. Animal studies plus many years of clinical experience suggest that there are no teratogenic effects. Fusidic acid is believed to cross the placental barrier when fusidic acid is administered systemically.

    The use of all medication in pregnancy should be avoided whenever possible; particularly in the first trimester. Non-drug treatments should also be considered. When essential, a medication with the best safety record over time should be chosen, employing the lowest effective dose for the shortest possible time. Polypharmacy should be avoided. Teratogens taken in the pre-embryonic period, often quoted as lasting until 14 to 17 days post-conception, are believed to have an all-or-nothing effect. Where drugs have a short half-life, and when the date of conception is certain, this may allow women to be reassured where drug exposure has occurred within this time frame. Further advice may be available from the UK National Teratology Information Service (NTIS) and through ToxBase, available via password on the internet ( ) or if this is unavailable at the backup site ( ).


    Fusidic acid should be used with caution in breastfeeding.

    Safety has not been established, although levels have been detected in breast milk when fusidic acid (as the sodium salt) has been administered systemically.

    Neonates, infants born prematurely, those with low birth weight, those with an unstable gastrointestinal function or who have serious illnesses may require special consideration. For any infant, if a drug is prescribed to the nursing mother, it should be at the lowest practical dose and for the shortest time. When drug administration is unavoidable and breastfeeding is to continue, minimisation of exposure of the infant to the drug may sometimes be achieved by timing the maternal doses to just after a feeding episode. Infants exposed to drugs via breast milk should be monitored for unusual signs or symptoms. Interactions between the drug received by the infant from the mother's milk and medication prescribed for the infant should also be considered, for example, when the drug given to the infant may prevent metabolism of the drug received via breast milk.
    Specialist advice is available from the UK Drugs in Lactation Advisory Service at

    Side Effects

    Abdominal pain
    Acute renal failure
    Allergic reaction
    Bone marrow depression
    Decreased erythrocyte count
    Haematological disorders
    Hepato-renal syndrome
    Increases in hepatic enzymes (reversible)
    Jaundice (reversible)
    Reduced platelet count


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: July 2014

    Reference Sources

    Martindale: The Complete Drug Reference, 37th edition (2011) ed. Sweetman, S. Pharmaceutical Press, London.

    Summary of Product Characteristics: Fucidin Suspension. Leo Laboratories Ltd. Revised August 2021.

    NICE - Evidence Services
    Available at:
    Last accessed: 29 June 2017.

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