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Glucosamine tablets and capsules


Oral formulations of glucosamine sulfate.

Drugs List

  • glucosamine sulfate 1500mg powder for oral solution sugar-free
  • Therapeutic Indications


    Relief of symptoms in mild to moderate osteoarthritis of the knee.

    Unlicensed Uses




    The usual dose is 1178 mg glucosamine daily.

    Refer to brand information.

    Additional Dosage Information

    Relief from symptoms may not be experienced until after several weeks of treatment. If no relief is experienced after 2 to 3 months re-evaluate treatment.


    Hypersensitivity to shellfish
    Children under 18 years
    Severe renal impairment
    Renal dialysis
    The powder for oral solution contains aspartame and is contraindicated in phenylketonuria

    Precautions and Warnings

    Monitor blood glucose levels in patients with impaired glucose tolerance. It is recommended that insulin requirements are monitored before the start of treatment and periodically during treatment
    Diabetes mellitus
    Patients with diabetes may experience fluctuations in blood glucose
    Monitor cholesterol levels in patients with predisposition to cardiovascular disease
    Risk factors for cardiovascular disorder
    Use with caution in asthmatic patients since glucosamine has been known to worsen symptoms
    Renal impairment
    Advise patient to take after food to reduce gastro-intestinal disturbances
    Advise patient drowsiness may affect ability to drive or operate machinery
    Some formulations contain sorbitol. Use with caution in patients with heriditary fructose intolerance
    Some formulations contain sodium. Use with caution in patients on a controlled sodium diet
    Some formulations contain aspartame. Use with caution in patients with phenylketonuria
    Discontinue if there is a rise in liver enzymes

    Pregnancy and Lactation


    Use glucosamine with caution during pregnancy.

    The manufacturer does not recommend using glucosamine during pregnancy. At the time of writing there is limited published information regarding the use of glucosamine during pregnancy. Potential risks are unknown.


    Use glucosamine with caution during breastfeeding.

    The manufacturer does not recommend breastfeeding whilst taking glucosamine. The presence of glucosamine in human breast milk and its effect on exposed infants are unknown. However, LactMed (2015) states its use by the nursing mother is unlikely to adversely affect the breastfed infant.

    Side Effects

    Decreased glycaemic control diabetes
    Increases in hepatic enzymes
    Abdominal pain
    Allergic reaction
    Visual disturbances


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: July 2019

    Reference Sources

    Summary of Product Characteristics: Dolenio 500mg Film coated tablets. Blue Bio Pharmaceuticals Ltd. Revised May 2018.
    Summary of Product Characteristics: Dolenio 750mg Film coated tablets. Blue Bio Pharmaceuticals Ltd. Revised August 2015.
    Summary of Product Characteristics: Dolenio 1500mg Film coated tablets. Blue Bio Pharmaceuticals Ltd. Revised August 2015.
    Summary of Product Characteristics: Glucosamine sulphate 1500mg powder for oral solution. Crescent Pharma Limited. Revised February 2019.

    US National Library of Medicine. Toxicology Data Network. Drugs and Lactation Database (LactMed).
    Available at:
    Glucosamine. Last revised: 3 December 2018
    Last accessed: 23 July 2019

    Specialist Pharmacy Service (SPS)
    Available at:
    Glucosamine Last revised: 17 April 2020
    Last accessed: 05 August 2020

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    Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content

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    FDB Disclaimer : FDB Multilex is intended for the use of healthcare professionals and is provided on the basis that the healthcare professionals will retain FULL and SOLE responsibility for deciding what treatment to prescribe or dispense for any particular patient or circumstance.