This site is intended for UK healthcare professionals
Medscape UK Univadis Logo
Medscape UK Univadis Logo


Cream containing hydrocortisone acetate and fusidic acid

Drugs List

  • FUCIDIN H cream
  • hydrocortisone acetate 1% and fusidic acid 2% cream
  • Therapeutic Indications


    Inflammatory skin conditions responsive to corticosteroid and antimicrobial

    Treatment of eczema and dermatitis with secondary bacterial infections including atopic eczema, primary irritant dermatitis, allergic dermatitis and seborrhoeic dermatitis where the infective organism is sensitive to fusidic acid.


    For uncovered lesions, a small quantity of cream applied to the affected area twice daily until a satisfactory response has been achieved.

    A single treatment course should not exceed 2 weeks.

    For covered lesions less frequent applications may be sufficient.


    Perioral dermatitis
    Uncontrolled skin manifestation of tuberculosis

    Precautions and Warnings

    Children under 12 years

    Exclude fungal infection before treatment
    Exclude primary bacterial infection before treatment
    Exclude tubercular infection before treatment
    Exclude viral infection before treatment
    Contains butyl hydroxyanisole - may cause local skin reactions
    Contains cetyl alcohol - may cause local skin reactions
    Contains polysorbate
    Avoid contact with mucous membranes
    Avoid prolonged application to the face
    Avoid use in or near eyes
    Do not apply to atrophic skin
    Not for use in open wounds
    Risk of glaucoma if preparation enters eye
    Adrenal suppression may occur even without occlusion
    Discontinue if no improvement occurs within 7 days
    Avoid long-term use particularly in infants and children
    Each course of treatment should not exceed 14 days
    Advise patient residue on clothing/bedding may cause fire hazard
    Fire hazard: Keep away from naked flames and potential sources of ignition

    Prolonged or repeated administration may increase the risk of contact sensitisation and bacterial resistance.

    Hydrocortisone with fusidic acid cream is not recommended in the following conditions: atrophic skin, cutaneous ulcer, acne vulgaris, fragile skin veins and perianal and genital pruritus.

    Due to the immunosuppressant effect of corticosteroids, hydrocortisone with fusidic acid cream may be associated with increased susceptibility to infection, aggravation of existing infection, and activation of latent infection. It is advised to switch to systemic therapy if infection cannot be controlled with topical treatment.

    Pregnancy and Lactation


    Use hydrocortisone with fusidic acid cream with caution in pregnancy.

    A large amount of data on pregnant women, over 1000, has shown no malformation or toxicity affecting the foetus or neonate after the use of corticosteroids.

    The use of all medication in pregnancy should be avoided whenever possible; particularly in the first trimester. Non-drug treatments should also be considered. When essential, a medication with the best safety record over time should be chosen, employing the lowest effective dose for the shortest possible time. Polypharmacy should be avoided. Teratogens taken in the pre-embryonic period, often quoted as lasting until 14 to 17 days post-conception, are believed to have an all-or-nothing effect. Where drugs have a short half-life, and when the date of conception is certain, this may allow women to be reassured where drug exposure has occurred within this time frame. Further advice may be available from the UK National Teratology Information Service (NTIS) and through ToxBase, available via password on the internet ( ) or if this is unavailable at the backup site ( ).


    Hydrocortisone with fusidic acid cream is considered safe for use in breastfeeding. However, the manufacturer recommends to avoid the application on the breast.

    Neonates, infants born prematurely, those with low birth weight, those with an unstable gastrointestinal function or who have serious illnesses may require special consideration. For any infant, if a drug is prescribed to the nursing mother, it should be at the lowest practical dose and for the shortest time. When drug administration is unavoidable and breastfeeding is to continue, minimisation of exposure of the infant to the drug may sometimes be achieved by timing the maternal doses to just after a feeding episode. Infants exposed to drugs via breast milk should be monitored for unusual signs or symptoms. Interactions between the drug received by the infant from the mother's milk and medication prescribed for the infant should also be considered, for example, when the drug given to the infant may prevent metabolism of the drug received via breast milk.
    Specialist advice is available from the UK Drugs in Lactation Advisory Service at

    Side Effects

    Adrenal suppression
    Burning sensation (local)
    Contact dermatitis
    Exacerbation of pre-existing eczema
    Hypersensitivity reactions
    Skin atrophy
    Skin depigmentation
    Skin irritation
    Striae (irreversible)


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: February 2017

    Reference Sources

    Joint Formulary Committee. British National Formulary. 72nd ed. London: BMJ Group and Pharmaceutical Press; 2016.

    Paediatric Formulary Committee. BNF for Children 2016-2017. London: BMJ Group, Pharmaceutical Press, and RCPCH Publications; 2016.

    Summary of Product Characteristics: Fucidin H cream. Leo Laboratories Ltd. Revised October 2014.

    Access the full UK drug database with a FREE Medscape UK Account
    It takes just a few minutes, and you’ll get unlimited access to information on over 11,000 UK drugs.
    Register for Free

    Already a member? Log in

    Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content

    FDB Logo

    FDB Disclaimer : FDB Multilex is intended for the use of healthcare professionals and is provided on the basis that the healthcare professionals will retain FULL and SOLE responsibility for deciding what treatment to prescribe or dispense for any particular patient or circumstance.