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Hyoscine hydrobromide transdermal


Transdermal patch containing hyoscine.

Drugs List

  • hyoscine 1mg/72hour patch
  • SCOPODERM 1.5mg patch
  • Therapeutic Indications


    Motion sickness

    Unlicensed Uses

    Excessive respiratory secretions



    Apply one patch to a clean dry hairless area of skin behind ear 5 to 6 hours before journey (or the evening before) avoiding any cuts or irritation.
    A fresh patch should be placed behind the other ear after 72 hours if further protection is required. Remove at end of journey.
    If a patch becomes accidentally detached, it should be replaced with a fresh one.


    Children aged 10 to 18 years
    (See Dosage; Adult)

    Excessive respiratory secretions (unlicensed)
    Children aged 10 to 18 years:1mg every 72 hours (one patch).
    Children aged 3 to 10 years:500 micrograms every 72 hours (half a patch).
    Children aged 1 month to 3 years: 250 micrograms every 72 hours (quarter of a patch).


    History of glaucoma

    Precautions and Warnings

    Children under 10 years
    Down's syndrome
    Bladder outflow obstruction
    Cardiovascular disorder
    Epileptic disorder
    Gastrointestinal obstruction
    Hepatic impairment
    History of raised intra-ocular pressure
    Prostate disorder
    Pyloric obstruction
    Renal impairment

    Advise patient drowsiness may affect ability to drive or operate machinery
    Advise visual disturbances may affect ability to drive or operate machinery
    May reduce seizure threshold
    Advise patient to wash hands after use
    Avoid contact with eyes
    Discard used patches safely - fold with adhesive edges together
    Remove metal containing patch prior to MRI scan
    Wash application site after use
    Perform eye tests before treatment
    Remove patch if confusional states or hallucinations occur
    Advise patient to avoid alcohol during treatment
    After removal of patch, side effects may persist for 24 hours or longer

    Pregnancy and Lactation


    Use hyoscine with caution in pregnancy.

    Hyoscine should only be used in pregnancy if the expected benefits to the mother outweigh the potential risks to the foetus.

    Functional effects i.e. on the foetal heart rate, must be considered with systemic use.

    The use of all medication in pregnancy should be avoided whenever possible; particularly in the first trimester. Non-drug treatments should also be considered. When essential, a medication with the best safety record over time should be chosen, employing the lowest effective dose for the shortest possible time. Polypharmacy should be avoided. Teratogens taken in the pre-embryonic period, often quoted as lasting until 14 to 17 days post-conception, are believed to have an all-or-nothing effect. Where drugs have a short half-life, and when the date of conception is certain, this may allow women to be reassured where drug exposure has occurred within this time frame. Further advice may be available from the UK National Teratology Information Service (NTIS) and through ToxBase, available via password on the internet ( ) or if this is unavailable at the backup site ( ).


    Use hyoscine with caution in breastfeeding.

    As hyoscine is only excreted in breast milk in trace amounts caution should be exercised when administering to a nursing mother.
    Hyoscine shows minimal, non-threatening adverse effects, but should be given only if potential benefit justifies the risk.

    Neonates, infants born prematurely, those with low birth weight, those with an unstable gastrointestinal function or who have serious illnesses may require special consideration. For any infant, if a drug is prescribed to the nursing mother, it should be at the lowest practical dose and for the shortest time. When drug administration is unavoidable and breastfeeding is to continue, minimisation of exposure of the infant to the drug may sometimes be achieved by timing the maternal doses to just after a feeding episode. Infants exposed to drugs via breast milk should be monitored for unusual signs or symptoms. Interactions between the drug received by the infant from the mother's milk and medication prescribed for the infant should also be considered, for example, when the drug given to the infant may prevent metabolism of the drug received via breast milk.
    Specialist advice is available from the UK Drugs in Lactation Advisory Service at


    Apply one patch to a clean hairless area of skin behind ear, avoiding cuts or irritation. If a patch becomes accidentally detached, it should be replaced with a fresh one.

    Advise patient to wash hands after application of patch. In addition, after removal of the system, the site of application should be washed; these precautions are necessary to minimise any chances of hyoscine being transferred to the eyes.

    Advise patient that limited contact with water (e.g. during swimming or washing) should not adversely affect the patch, although it should be kept as dry as possible.

    Advise patients that hyoscine may cause drowsiness, dizziness, confusion or visual disturbances which may persist for up to 24 hours or longer after removal of the patch. Patients using the patch should not drive or operate machinery.

    Advise patient not to consume alcohol whilst using the patch.

    Advise patient to remove the patch immediately if confusion or visual hallucinations occur.

    Side Effects

    Acute glaucoma
    Attention disturbances
    Blurred vision
    Bradycardia then tachycardia
    Contact dermatitis
    Decreased bronchial secretions
    Difficulty in micturition
    Difficulty in swallowing
    Disturbances in accommodation
    Dry mouth
    Dry skin
    Eyelid itching
    Eyelid reaction
    Impaired concentration
    Impaired memory
    Irritation (localised)
    Loss of balance
    Pupillary dilatation
    Urinary retention
    Visual disturbances
    Withdrawal symptoms


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: July 2014

    Reference Sources

    Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment, 2nd edition (2007) ed. Schaefer, C., Peters, P. and Miller, R. Elsevier, London.

    Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 9th edition (2011) ed. Briggs, G., Freeman, R. and Yaffe, S. Lippincott Williams & Wilkins, Philadelphia.

    Martindale: The Complete Drug Reference, 37th edition (2011) ed. Sweetman, S. Pharmaceutical Press, London.

    Medications and Mothers' Milk, 14th Edition (2010) Hale, T. Hale Publishing, Amarillo, Texas.

    Summary of Product Characteristics: Scopoderm TTS. Novartis Consumer Health. Revised September 2012.

    Summary of Product Characteristics: Scopoderm 1.5mg patch. Novartis Consumer Health. Revised May 2014.

    NICE Evidence Services Available at: Last accessed: 25 August 2017

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    Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content

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    FDB Disclaimer : FDB Multilex is intended for the use of healthcare professionals and is provided on the basis that the healthcare professionals will retain FULL and SOLE responsibility for deciding what treatment to prescribe or dispense for any particular patient or circumstance.