Isoprenaline hydrochloride parenteral
- Drugs List
- Therapeutic Indications
- Precautions and Warnings
- Pregnancy and Lactation
- Side Effects
Parenteral formulations of isoprenaline hydrochloride.
Permanent bradycardia due to atrioventricular block
Temporary prevention/control of Stokes-Adams attacks
Treatment of permanent bradycardia due to atrio-ventricular block pending or in the case of contraindication of a pacemaker.
Treatment of Adams-Stokes syndrome.
The lowest dose of isoprenaline hydrochloride should be carefully titrated under close monitoring to obtain a heart rate of 50 to 60 beats per minute. The rate of infusion should be adjusted based on the heart rate of the patient.
Initial dose of 10nanograms/kg/minute. The dose can be increased in increments of 10nanograms/kg/minute until a maximum dose of 150nanograms/kg/minute.
Additional Dosage Information
Concomitant use with adrenaline
Do not inject isoprenaline hydrochloride at the same time as adrenaline in any circumstances. However, if required isoprenaline hydrochloride and adrenaline can be given alternately every 4 hours.
For intravenous use only.
Cardiac glycoside toxicity
Recent myocardial infarction
Precautions and Warnings
Must be diluted before use
Treatment with isoprenaline hydrochloride requires ECG monitoring and reduction of doses in the case of ventricular myocardial hyperexcitability (polymorphic extrasystoles, repetitive burst pacing or ventricular tachycardia).
Caution should be taken when doses are sufficient to reach a heart rate of 130 beats per minute.
Caution when treating patients who respond to sympathomimetic amines in an unusual a manner.
Hypertension may occur due to the high vasopressor effect of sympathomimetic vasoconstrictors.
Pregnancy and Lactation
Use isoprenaline hydrochloride with caution during pregnancy.
The manufacturer advises carefully weighing up the clinical benefits against the possible risk to mother and child if using isoprenaline hydrochloride during pregnancy. Available reports indicate no increased risk of teratogenic or developmental effects.
Isoprenaline hydrochloride is contraindicated during breastfeeding.
The manufacturer does not recommend breastfeeding whilst taking isoprenaline hydrochloride. Effects on exposed infants are unknown.
Decrease in blood pressure
Increased blood pressure
Increased heart rate
It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.
The following number will direct the caller to the relevant local centre (0844) 892 0111
Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ).
Last Full Review Date: June 2021
Summary of Product Characteristics: Isoprenaline Macure 0.2mg/ml concentrate for solution for infusion. Macure Pharma UK Ltd. Revised December 2020.
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Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content
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