Ketorolac trometamol ocular
- Drugs List
- Therapeutic Indications
- Precautions and Warnings
- Pregnancy and Lactation
- Side Effects
Eye drops containing ketorolac trometamol (preservative containing).
Topical prophylaxis and treatment of inflammation after ocular surgery
Instil 1 drop into the affected eye(s) three times a day starting 24 hours pre-operatively and continuing for up to 21 days post-operatively.
Corneal epithelial breakdown
Precautions and Warnings
Children under 18 years
Soft contact lenses
May mask symptoms or signs of infections
Advise patient blurred vision may affect ability to drive/operate machinery
Contains benzalkonium chloride. Not to be used with soft contact lenses
In combined therapy, administer eye products at least five minutes apart
To reduce systemic absorption compress lacrimal sac during administration
Monitor for, and discontinue in, corneal epithelial breakdown
Monitor patients for development of keratitis
May prolong bleeding time
Advise patient to avoid touching the eye/other surfaces with container tip
If soft contact lenses worn,insert them 15 minutes after using eye drops
This medication should be used with caution in patients with complicated ocular surgeries, corneal denervation, corneal epithelial defects, diabetes mellitus, ocular surface diseases (for example, dry eye syndrome), rheumatoid arthritis, or repeat ocular surgeries within a short period of time, as they may be at increased risk for corneal adverse events which may become sight threatening.
Pregnancy and Lactation
Ketorolac trometamol is contraindicated during pregnancy.
The manufacturer does not recommend ketorolac trometamol during pregnancy. Available studies have shown teratogenic effects including cardiac defects, orofacial clefts and spontaneous abortions following the use of ketorolac trometamol during pregnancy. Some studies suggested there was most risk of teratogenic effects in the 1st and 3rd trimesters (Briggs 2015).
Ketorolac trometamol is contraindicated during breastfeeding.
The manufacturer states ketorolac trometamol eye drops should not be used during breastfeeding. Whilst available data shows ketorolac trometamol is present in breast milk, the amount was considered insignificant (Briggs 2015). Studies on lactation whilst using ketorolac trometamol are limited but there is no evidence of negative impact on ability to breastfeed (Lactmed 2022).
Blurred vision (transient)
Dryness of eyes
Superficial punctate keratitis
It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.
The following number will direct the caller to the relevant local centre (0844) 892 0111
Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ).
Last Full Review Date: July 2022
Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 10th edition (2015) ed. Briggs, G., Freeman, R. and Yaffe, S. Lippincott Williams & Wilkins, Philadelphia.
Summary of Product Characteristics: Acular, AbbVie Ltd, revised April 2022.
NICE Evidence Services Available at: www.nice.org.uk Last accessed: 22 July 2022
US National Library of Medicine. Toxicology Data Network. Drugs and Lactation Database (LactMed).
Available at: https://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT
Ketorolac Last revised: April 2022
Last accessed: July 2022
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Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content
FDB Disclaimer : FDB Multilex is intended for the use of healthcare professionals and is provided on the basis that the healthcare professionals will retain FULL and SOLE responsibility for deciding what treatment to prescribe or dispense for any particular patient or circumstance.