This site is intended for UK healthcare professionals
Medscape UK Univadis Logo
Medscape UK Univadis Logo

Lidocaine topical


Topical formulation of lidocaine.

Drugs List

  • LIDBREE 42mg/1ml intrauterine gel
  • lidocaine 42mg/ml intrauterine gel
  • Therapeutic Indications


    Local anaesthesia

    Topical anaesthesia for moderate acute pain during cervical and intrauterine procedures.



    Cervical procedures
    Apply 2ml to 3ml in a thick layer to the portio using the sterile applicator, and 3ml into the cervical canal 5 minutes before the start of the procedure.

    Intrauterine procedures
    Apply 1ml to 2ml to the anterior lip of the portio and 2ml to 3ml into the cervical canal using the sterile applicator. After 2 minutes, insert the applicator into the uterine cavity and apply 3ml to 5ml, 5 minutes before the procedure. A single intrauterine dose should not exceed a total of 10ml.


    Children aged 15 years and over and weighing over 30kg
    (See Dosage; Adult)

    Children aged 15 years and over and weighing 30kg or less
    1.2ml per 10kg body weight. Maximum dose is 3.6ml in total.


    Children under 15 years

    Precautions and Warnings

    Children aged 15 to 18 years
    Acute porphyria
    Atrioventricular block

    Contains butylated hydroxytoluene - May irritate skin/eyes/mucous membranes
    Contains castor oil polyoxyl - may cause severe allergic reactions
    Avoid accidental intravascular injection

    In the event of difficult insertion of intrauterine contraceptives and/or exceptional pain or bleeding during or following insertion, physical examination and ultrasound should be performed immediately to rule out perforation of the uterine corpus or cervix.

    Pregnancy and Lactation


    Use topical lidocaine with caution during pregnancy.

    The manufacturer advises caution if topical lidocaine is used during pregnancy. At the time of writing there is limited published information regarding the use of topical lidocaine during pregnancy. Potential risks are unknown.


    Parenteral lidocaine should be used with caution during breastfeeding but topical lidocaine is considered safe for use during breastfeeding.

    The manufacturer states topical lidocaine may be used safely when breastfeeding. Whilst available data indicates that topical lidocaine is present in human breast milk, the quantity is not considered to be sufficient to cause adverse effects in the breastfed infant.

    Side Effects

    Gastrointestinal disorder


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: December 2022

    Reference Sources

    Summary of Product Characteristics: Lidbree 42mg/ml intrauterine gel. Gedeon Richter (UK) Ltd. Revised July 2021.

    Access the full UK drug database with a FREE Medscape UK Account
    It takes just a few minutes, and you’ll get unlimited access to information on over 11,000 UK drugs.
    Register for Free

    Already a member? Log in

    Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content

    FDB Logo

    FDB Disclaimer : FDB Multilex is intended for the use of healthcare professionals and is provided on the basis that the healthcare professionals will retain FULL and SOLE responsibility for deciding what treatment to prescribe or dispense for any particular patient or circumstance.