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Loratadine oral

Updated 2 Feb 2023 | Non-sedating antihistamines


Oral formulations of loratadine.

Drugs List

  • BELL'S CHILDREN'S ALLERGY RELIEF 5mg/5ml oral solution
  • CLARITYN ALLERGY 10mg tablets
  • LORAPAED ALLERGY RELIEF 5mg/5ml oral solution
  • loratadine 10mg tablets
  • loratadine 5mg/5ml oral solution
  • loratadine 5mg/5ml oral solution sugar-free
  • Therapeutic Indications


    Allergic rhinitis - perennial and seasonal
    Chronic idiopathic urticaria



    10mg once daily.


    Children over 12 years
    10mg once daily.

    Children 2 to 12 years of age with body weight more than 30kg
    10mg once daily.

    Children 2 to 12 years of age with body weight 30kg or less
    5mg once daily.

    Patients with Hepatic Impairment

    Severe Hepatic Impairment

    Adults and children weighing more than 30kg
    An initial dose of 10mg every other day.

    Children weighing 30kg or less
    An initial dose of 5mg every other day.


    Children under 2 years

    Precautions and Warnings

    Weight below 30kg
    Glucose-galactose malabsorption syndrome
    Hereditary fructose intolerance
    Lactose intolerance
    Severe hepatic impairment

    Reduce dose in patients with severe hepatic impairment
    Advise patient drowsiness may affect ability to drive or operate machinery
    Not all formulations suitable for patients with body weight 30kg or less
    Oral solution with maltitol unsuitable in hereditary fructose intolerance
    Some formulations contain lactose
    Some formulations contain sucrose
    Discontinue 48 hours before skin tests involving allergies

    Pregnancy and Lactation


    Use loratadine with caution during pregnancy.

    The manufacturers note that it is preferable not to use this medication pregnancy.

    Although it is not known if loratadine crosses the human placenta, the molecular weight, about 383, is low enough for passage to the foetus to be expected.

    There is no evidence of increased teratogenicity in animals or humans. Human experience indicates that loratadine, in line with other antihistamines, is not a major human teratogen. If an oral antihistamine agent is required during pregnancy, first generation agents such as chlorpheniramine or tripelennamine should be considered. However, loratadine and cetirizine are acceptable alternatives, except during the 1st trimester, if a first-generation drug was not tolerated.


    Use loratadine with caution during breastfeeding.

    The manufacturers note that this medication is not recommended during breastfeeding.

    Loratadine and its metabolite, descarboethoxyloratadine, are excreted into human milk.

    Side Effects

    Abnormal liver function
    Dry mouth
    Hypersensitivity reactions
    Increased appetite
    Weight gain


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: April 2019

    Reference Sources

    Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 10th edition (2015) ed. Briggs, G., Freeman, R. Wolters Kluwer Health, Philadelphia.

    Summary of Product Characteristics: Bells Healthcare Children's Allergy Relief 5mg/5ml Oral Solution. Relonchem Limited. Revised May 2022.

    Summary of Product Characteristics: Clarityn Allergy 1mg/ml syrup. Bayer plc. Revised October 2015.

    Summary of Product Characteristics: Clarityn Allergy 10mg tablets. Bayer plc. Revised August 2018.

    Summary of Product Characteristics: Clarityn Rapide Allergy 10mg tablets. Bayer plc. Revised March 2018.

    Summary of Product Characteristics: Lorapaed Allergy Relief 5mg/5ml Oral Solution. Pinewood Healthcare. Revised July 2016.

    Summary of Product Characteristics: Loratadine 5mg/5ml Oral Solution. Torrent Pharma (UK) Ltd. Revised July 2018.

    NICE Evidence Services Available at: Last accessed: 16 November 2022

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