Metronidazole cream 0.75%
- Drugs List
- Therapeutic Indications
- Dosage
- Contraindications
- Precautions and Warnings
- Pregnancy and Lactation
- Side Effects
- Monograph
Presentation
Cream containing metronidazole.
Drugs List
Therapeutic Indications
Uses
Treatment of rosacea
Dosage
Adults
1 application twice a day. Duration of treatment varies according to brand but should not exceed 4 months.
Children
Children aged 1 to 18 years (unlicensed)
1 application twice a day.
Contraindications
Children under 1 year
Breastfeeding
Precautions and Warnings
Children aged 1 to 18 years
Central nervous system disorder
Haematological disorder
History of haematological disorder
Pregnancy
Severe hepatic impairment
Some formulations contain propylene glycol
Avoid contact with mucous membranes
Avoid use in or near eyes
If accidental contact with the eyes occurs, rinse thoroughly with water
Marked skin irritation - interrupt treatment/reduce application frequency
Advise patient to avoid alcohol during treatment
Advise pt. to minimise exposure to sunlight & avoid sunlamps during therapy
Pregnancy and Lactation
Pregnancy
Use metronidazole cream with caution during pregnancy.
One manufacturer advises that metronidazole cream is contraindicated during the first trimester of pregnancy. However, another manufacturer advises that this medication should only be used in pregnancy if clearly needed. At the time of writing there is limited human data available. With oral administration, metronidazole crosses the placental barrier and enters the foetal circulation. Some studies have indicated an increased risk of malformations and carcinogenic risk but these have not been clarified.
Lactation
Metronidazole cream is contraindicated during breastfeeding.
The manufacturer advises discontinuing breastfeeding or discontinuing metronidazole. Metronidazole is excreted into human breast milk. Up to 100% of the plasma value can be reached after oral use. In topical application of metronidazole, these plasma levels are lower.
Side Effects
Anaphylaxis
Angioedema
Burning sensation (local)
Contact dermatitis
Dry skin
Erythema
Hypoesthesia
Metallic taste
Nausea
Pain
Paraesthesia
Pruritus
Rash
Skin exfoliation
Skin irritation
Stinging
Watering eyes
Worsening of rosacea
Overdosage
It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.
The following number will direct the caller to the relevant local centre (0844) 892 0111
Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ).
Further Information
Last Full Review Date: December 2019
Reference Sources
Summary of Product Characteristics: Rozex 0.75% w/w cream. Galderma (U.K.) Ltd. Revised August 2013.
Summary of Product Characteristics: Rosiced 7.5mg/g cream. Pierre Fabre Dermatologie. Revised March 2015.
Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content
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