Mizolastine tablets 10mg
- Drugs List
- Therapeutic Indications
- Dosage
- Contraindications
- Precautions and Warnings
- Pregnancy and Lactation
- Side Effects
- Monograph
Presentation
Oral formulations of mizolastine.
Drugs List
Therapeutic Indications
Uses
Seasonal and perennial allergic rhino-conjunctivitis
Urticaria
Dosage
Adults
10mg once a day.
Children
Children aged 12 years and over
10mg once a day.
Contraindications
Children under 12 years
Bradycardia
Breastfeeding
Cardiac arrhythmias
Galactosaemia
History of cardiac arrhythmias
Hypokalaemia
Long QT syndrome
Pregnancy
Severe cardiac dysfunction
Severe hepatic impairment
Torsade de pointes
Precautions and Warnings
Elderly
Family history of long QT syndrome
Diabetes mellitus
Electrolyte imbalance
Glucose-galactose malabsorption syndrome
History of torsade de pointes
Lactose intolerance
Correct electrolyte disorders before treatment
Advise ability to drive/operate machinery may be affected by side effects
Contains castor oil - may cause adverse gastrointestinal effects
Contains lactose
Consider monitoring ECG in patients at risk of QT prolongation
Monitor serum electrolytes
Pregnancy and Lactation
Pregnancy
Mizolastine is contraindicated during pregnancy.
The manufacturer does not recommended the use of mizolastine during pregnancy, particularly during the first trimester.
Animal studies do not indicate harmful effects regarding the development of the embryo or foetus, the course of gestation and peri and post natal development.
Lactation
Mizolastine is contraindicated during breastfeeding.
The manufacturer does not recommended breastfeeding whilst taking mizolastine. Available data indicates mizolastine is expressed in human breast milk, but the quantity is unknown.
Side Effects
Abdominal pain
Aggravation of existing asthma
Allergic reaction
Anaphylaxis
Angioedema
Anxiety
Arrhythmias
Arthralgia
Asthenia
Blood sugar changes
Bronchospasm
Depression
Diarrhoea
Dizziness
Drowsiness
Dry mouth
Dyspepsia
Electrolyte disturbances
Headache
Hypotension
Increased appetite
Increases in hepatic enzymes
Low neutrophil count
Myalgia
Nausea
Palpitations
Prolongation of QT interval
Pruritus
Rash
Tachycardia
Urticaria
Vasovagal attacks
Vomiting
Weight gain
Overdosage
It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.
The following number will direct the caller to the relevant local centre (0844) 892 0111
Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ).
Further Information
Last Full Review Date: May 2021
Reference Sources
Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment, 3rd edition (2015) ed. Schaefer, C., Peters, P. and Miller, R. Elsevier, London.
Summary of Product Characteristics: Mizollen 10mg modified release tablets. Sanofi Aventis. Revised September 2019.
NICE Evidence Services Available at: www.nice.org.uk Last accessed: 10 May 2021.
Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content
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