Drugs List

Therapeutic Indications

Uses

Bacterial ocular infection: topical treatment

Treatment of external infections of the eye and its adnexa caused by netilmicin sensitive bacteria.

Contraindications

Children under 18 years
Breastfeeding

Precautions and Warnings

Pregnancy

Advise patient blurred vision may affect ability to drive/operate machinery
Consult national/regional policy on the use of anti-infectives
In combined therapy, administer eye products at least five minutes apart
To reduce systemic absorption compress lacrimal sac during administration
Prolonged use may result in infection due to resistant organisms
Advise patient to avoid touching the eye/other surfaces with container tip
Advise patient to consult physician if condition worsens / does not improve
Contact lenses should not be worn during treatment

Serious adverse reactions including neurotoxicity, ototoxicity and nephrotoxicity have occurred in patients receiving systemic aminoglycoside therapy. Caution is advised when used concomitantly.

According to the MHRA/CHM advice, there is an increased risk of ototoxicity when aminoglycosides are administered to patients with mitochondrial mutations, including cases where the patient's aminoglycoside serum levels were within the recommended age. Monitor renal, auditory function, hepatic and laboratory parameters to reduce the risks of adverse reactions.

Pregnancy and Lactation

Pregnancy

Use netilmicin with caution during pregnancy.

The manufacturer advises that netilmicin should be administered only after a careful benefit-risk assessment and under strict control. Preclinical studies show no foetal toxicity with topical administration of netilmicin.

Lactation

Netilmicin is contraindicated during breastfeeding.

The manufacturer does not recommend breastfeeding whilst taking netilmicin. Aminoglycosides are excreted in breast milk in small amounts. Effects on exposed infants are unknown.

Side Effects

Blurred vision
Conjunctival hyperaemia
Eye erythema
Eye irritation
Eye pruritus
Eyelid oedema
Eyelid rash
Hypersensitivity reactions
Nephrotoxicity
Neurotoxicity
Ocular discomfort
Ototoxicity
Skin reactions
Urticaria

Presentation

Eye drops containing netilmicin.

Drugs List

Therapeutic Indications

Uses

Bacterial ocular infection: topical treatment

Treatment of external infections of the eye and its adnexa caused by netilmicin sensitive bacteria.

Dosage

Adults

Contraindications

Children under 18 years
Breastfeeding

Precautions and Warnings

Pregnancy

Advise patient blurred vision may affect ability to drive/operate machinery
Consult national/regional policy on the use of anti-infectives
In combined therapy, administer eye products at least five minutes apart
To reduce systemic absorption compress lacrimal sac during administration
Prolonged use may result in infection due to resistant organisms
Advise patient to avoid touching the eye/other surfaces with container tip
Advise patient to consult physician if condition worsens / does not improve
Contact lenses should not be worn during treatment

Serious adverse reactions including neurotoxicity, ototoxicity and nephrotoxicity have occurred in patients receiving systemic aminoglycoside therapy. Caution is advised when used concomitantly.

According to the MHRA/CHM advice, there is an increased risk of ototoxicity when aminoglycosides are administered to patients with mitochondrial mutations, including cases where the patient's aminoglycoside serum levels were within the recommended age. Monitor renal, auditory function, hepatic and laboratory parameters to reduce the risks of adverse reactions.

Pregnancy and Lactation

Pregnancy

Use netilmicin with caution during pregnancy.

The manufacturer advises that netilmicin should be administered only after a careful benefit-risk assessment and under strict control. Preclinical studies show no foetal toxicity with topical administration of netilmicin.

Lactation

Netilmicin is contraindicated during breastfeeding.

The manufacturer does not recommend breastfeeding whilst taking netilmicin. Aminoglycosides are excreted in breast milk in small amounts. Effects on exposed infants are unknown.

Side Effects

Blurred vision
Conjunctival hyperaemia
Eye erythema
Eye irritation
Eye pruritus
Eyelid oedema
Eyelid rash
Hypersensitivity reactions
Nephrotoxicity
Neurotoxicity
Ocular discomfort
Ototoxicity
Skin reactions
Urticaria

Overdosage

It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

The following number will direct the caller to the relevant local centre (0844) 892 0111

Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ).

Further Information

Last Full Review Date: June 2022

Reference Sources

Summary of Product Characteristics: Nettacin 3mg/ml eye drops. ParaPharm Development Limited. Revised March 2021.

NICE Evidence Services Available at: www.nice.org.uk Last accessed: 27 September 2022