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Nystatin and chlorhexidine and hydrocortisone cream


Cream containing nystatin, chlorhexidine acetate and hydrocortisone.

Drugs List

  • NYSTAFORM -HC cream
  • nystatin 100000unit/g and chlorhexidine 1% and hydrocortisone 0.5% cream
  • Therapeutic Indications


    Infected dermatoses responsive to topical corticosteroids



    1 application to infected area one to three times daily.

    Maximum treatment duration should be 7 days.


    1 application to infected area one to three times daily.

    Maximum treatment duration should be 5 to 7 days.


    Acne vulgaris
    Skin manifestation of tuberculosis
    Widespread plaque psoriasis

    Precautions and Warnings

    Occlusive dressings

    Contains benzyl alcohol
    Contains polysorbate
    Some formulations contain cetostearyl alcohol
    Avoid contact with eyes
    Avoid contact with mucous membranes
    Avoid prolonged application to the face
    Prolonged/excessive use may lead to adrenal suppression
    Discontinue if sensitisation occurs
    Discontinue if superinfection occurs
    Avoid long-term use particularly in infants and children
    Treatment should be for a maximum period of 7 days
    Nappy may act as an occlusive dressing

    Pregnancy and Lactation


    Use nystatin, chlorhexidine and hydrocortisone with caution during pregnancy.

    The manufacturer advises that the benefit of treatment must outweigh potential risks to the infant.


    Use nystatin, chlorhexidine and hydrocortisone with caution during breastfeeding.

    Side Effects

    Acne (at application site)
    Adrenal suppression
    Anaphylactic shock
    Blisters (application site)
    Contact dermatitis
    Cushing's syndrome
    Exacerbation of infection
    Hypersensitivity reactions
    Irritation at application site
    Local burning
    Perioral dermatitis
    Skin depigmentation
    Skin irritation
    Striae (irreversible)
    Thinning of skin


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: October 2021

    Reference Sources

    Summary of Product Characteristics: Nystaform HC Cream Typham Ltd. Revised August 2021.
    Summary of Product Characteristics: Nystatin/Chlorhexidine hydrochloride/Hydrocortisone 100,000Units/g/1%/0.5% Cream. Typham Ltd. Revised January 2016.

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    Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content

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    FDB Disclaimer : FDB Multilex is intended for the use of healthcare professionals and is provided on the basis that the healthcare professionals will retain FULL and SOLE responsibility for deciding what treatment to prescribe or dispense for any particular patient or circumstance.