Opium tincture (morphine) oral
- Drugs List
- Therapeutic Indications
- Dosage
- Administration
- Contraindications
- Precautions and Warnings
- Pregnancy and Lactation
- Side Effects
- Monograph
Presentation
Oral formulations of morphine in opium tincture.
1 drop contains 50mg opium tincture corresponding to 0.5mg (10mg/ml) anhydrous morphine.
1ml = 20 drops.
Drugs List
Therapeutic Indications
Uses
Diarrhoea
Dosage
Adults
5 to 10 drops, two to three times a day.
Dose should depend on patient's condition, age, weight and medical history.
Dose should not exceed 1ml and total daily dose should not exceed 6ml.
Administration
To be administered undiluted or mixed in a glass of water. If mixed with water it should be used immediately.
Contraindications
Children under 18 years
Risk of paralytic ileus
Acute asthma
Breastfeeding
Cardiac failure secondary to pulmonary disorder
Chronic obstructive pulmonary disease
Delirium tremens
Glaucoma
Head trauma
Opioid dependence
Severe hepatic impairment
Severe renal impairment
Severe respiratory depression
Third trimester of pregnancy
Precautions and Warnings
Chronic infection
Elderly
Impaired consciousness
Adrenal insufficiency
Alcoholism
Benign prostatic hyperplasia
Biliary colic
Cardiorespiratory insufficiency
Cholelithiasis
Chronic hepatic disorder
Chronic renal disorder
Drug misuse
Epileptic disorder
First trimester of pregnancy
Gastrointestinal haemorrhage
History of alcohol abuse
History of drug misuse
Hypothyroidism
Hypovolaemia
Inflammatory bowel disease
Pancreatitis
Raised intracranial pressure
Second trimester of pregnancy
Reduce dose in hypothyroidism
Reduce dose in patients with hepatic impairment
Reduce dose in patients with renal impairment
Advise patient drowsiness may affect ability to drive or operate machinery
Reduce initial dose in the elderly
Treatment to be initiated and supervised by a specialist
Contains alcohol
Advise patient to report a difficulty to urinate
Discontinue if paralytic ileus is suspected
Discontinue prior to surgery and within 24hrs after surgery
Patient should avoid alcohol as effect may be potentiated
Female: Ensure adequate contraception during treatment
Male: Ensure adequate contraception during treatment
Ensure the treatment period is as short as possible as repeated administration may cause dependence and tolerance and may lead to the addiction of the substance.
Use with caution and at reduced dose in patients who are also being treated with other narcotic agents, sedatives, and tricyclic antidepressants and MAO-inhibitors.
Pregnancy and Lactation
Pregnancy
Morphine in opium tincture is contraindicated during the third trimester of pregnancy.
Morphine in opium tincture should be used with caution during the first and second trimester of pregnancy.
Use in the third trimester may cause drowsiness and respiratory depression or withdrawal symptoms in the neonate.
Lactation
Morphine in opium tincture is contraindicated during breastfeeding.
The manufacturer recommends morphine in opium tincture is not used in pregnancy as opium passes into human milk with the milk to plasma concentration being 1:4.
Side Effects
Asthenia
Bradycardia
Bronchospasm
Constipation
Dizziness
Drowsiness
Euphoria
Increases in hepatic enzymes
Involuntary muscle contractions
Miosis
Nausea
Orthostatic hypotension
Pruritus
Respiratory depression
Stomatitis
Tachycardia
Urinary retention
Vomiting
Overdosage
It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.
The following number will direct the caller to the relevant local centre (0844) 892 0111
Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ).
Further Information
Last Full Review Date: May 2019
Reference Sources
Summary of Product Characteristics: Dropizol 10mg/ml oral drops. Pharmanovia A/S. Revised March 2020.
NICE Evidence Services Available at: www.nice.org.uk Last accessed: 16 January 2023
Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content
FDB Disclaimer : FDB Multilex is intended for the use of healthcare professionals and is provided on the basis that the healthcare professionals will retain FULL and SOLE responsibility for deciding what treatment to prescribe or dispense for any particular patient or circumstance.