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Opium tincture (morphine) oral

Updated 2 Feb 2023 | Antimotility drugs


Oral formulations of morphine in opium tincture.

1 drop contains 50mg opium tincture corresponding to 0.5mg (10mg/ml) anhydrous morphine.

1ml = 20 drops.

Drugs List

  • DROPIZOL 10mg/ml (morphine) oral drops sugar-free
  • opium tincture (morphine) 10mg/ml oral drops sugar-free
  • Therapeutic Indications





    5 to 10 drops, two to three times a day.

    Dose should depend on patient's condition, age, weight and medical history.

    Dose should not exceed 1ml and total daily dose should not exceed 6ml.


    To be administered undiluted or mixed in a glass of water. If mixed with water it should be used immediately.


    Children under 18 years
    Risk of paralytic ileus
    Acute asthma
    Cardiac failure secondary to pulmonary disorder
    Chronic obstructive pulmonary disease
    Delirium tremens
    Head trauma
    Opioid dependence
    Severe hepatic impairment
    Severe renal impairment
    Severe respiratory depression
    Third trimester of pregnancy

    Precautions and Warnings

    Chronic infection
    Impaired consciousness
    Adrenal insufficiency
    Benign prostatic hyperplasia
    Biliary colic
    Cardiorespiratory insufficiency
    Chronic hepatic disorder
    Chronic renal disorder
    Drug misuse
    Epileptic disorder
    First trimester of pregnancy
    Gastrointestinal haemorrhage
    History of alcohol abuse
    History of drug misuse
    Inflammatory bowel disease
    Raised intracranial pressure
    Second trimester of pregnancy

    Reduce dose in hypothyroidism
    Reduce dose in patients with hepatic impairment
    Reduce dose in patients with renal impairment
    Advise patient drowsiness may affect ability to drive or operate machinery
    Reduce initial dose in the elderly
    Treatment to be initiated and supervised by a specialist
    Contains alcohol
    Advise patient to report a difficulty to urinate
    Discontinue if paralytic ileus is suspected
    Discontinue prior to surgery and within 24hrs after surgery
    Patient should avoid alcohol as effect may be potentiated
    Female: Ensure adequate contraception during treatment
    Male: Ensure adequate contraception during treatment

    Ensure the treatment period is as short as possible as repeated administration may cause dependence and tolerance and may lead to the addiction of the substance.

    Use with caution and at reduced dose in patients who are also being treated with other narcotic agents, sedatives, and tricyclic antidepressants and MAO-inhibitors.

    Pregnancy and Lactation


    Morphine in opium tincture is contraindicated during the third trimester of pregnancy.

    Morphine in opium tincture should be used with caution during the first and second trimester of pregnancy.

    Use in the third trimester may cause drowsiness and respiratory depression or withdrawal symptoms in the neonate.


    Morphine in opium tincture is contraindicated during breastfeeding.

    The manufacturer recommends morphine in opium tincture is not used in pregnancy as opium passes into human milk with the milk to plasma concentration being 1:4.

    Side Effects

    Increases in hepatic enzymes
    Involuntary muscle contractions
    Orthostatic hypotension
    Respiratory depression
    Urinary retention


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: May 2019

    Reference Sources

    Summary of Product Characteristics: Dropizol 10mg/ml oral drops. Pharmanovia A/S. Revised March 2020.

    NICE Evidence Services Available at: Last accessed: 16 January 2023

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