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Piracetam oral formulations


Oral formulations of piracetam.

Drugs List

  • NOOTROPIL 1200mg film coated tablets
  • NOOTROPIL 33% oral solution
  • NOOTROPIL 800mg film coated tablets
  • piracetam 1.2g tablets
  • piracetam 333.3mg/ml oral solution sugar-free
  • piracetam 800mg tablets
  • Therapeutic Indications


    Myoclonus of cortical origin

    Treatment of adult patients with myoclonus of cortical origin, in conjunction with other anti-myoclonic therapies, regardless of aetiology.



    Initial dose: 7.2g daily in 2 to 3 partial doses.
    Dose can be increased by 4.8g per day every 3 to 4 days, depending on patient response.
    Maximum dose is 24g daily.

    Patients with Renal Impairment

    Creatinine clearance 50-80ml/min: Use two thirds of the usual daily dose, in 2 to 3 sub-doses.
    Creatinine clearance 30-50ml/min: Use one third of the usual daily dose, in 2 to 3 sub-doses.
    Creatinine clearance 20-30ml/min: Use one sixth of the usual daily dose administered once daily.
    Creatinine clearance less than 20ml/min: Contraindicated.

    Additional Dosage Information

    Continue treatment with piracetam for as long as the original cerebral disease persists. In patients with an acute episode, spontaneous evolution can occur in time, so every 6 months an attempt to decrease or discontinue treatment should be made. This should be done by reducing the dose of piracetam by 1.2g every 2 days.
    (In the case of a Lance and Adams syndrome this should be reduced to every 3 or 4 days to prevent the possibility of sudden relapse or withdrawal symptoms.)

    Other anti-myoclonic drugs should remain unchanged at their optimal dosage.
    An attempt can be made to subsequently reduce the dosage of the other anti-myoclonic drugs, based on the individual clinical benefit.


    Children under 18 years
    Huntington's chorea
    Recent cerebral haemorrhage
    Renal impairment - creatinine clearance below 20ml/minute

    Precautions and Warnings

    Major surgery
    Predisposition to haemorrhage
    Severe haemorrhage
    Gastrointestinal ulcer
    History of haemorrhagic cerebrovascular accident
    Impaired haemostasis
    Renal impairment - creatinine clearance 20-79ml/min

    Sodium content of formulation may be significant
    Advise ability to drive/operate machinery may be affected by side effects
    Oral liquid contains hydroxybenzoate: caution in hypersensitivity
    Oral solution contains glycerol
    Monitor renal function in elderly patients
    Review treatment every 6 months
    Avoid abrupt withdrawal

    Pregnancy and Lactation


    Piracetam is contraindicated in pregnancy.

    The manufacturer recommends that piracetam must be avoided during pregnancy unless the benefit for the mother exceeds the risks.
    According to the manufacturer, piracetam crosses the placenta, with newborn levels being 70% to 90% of maternal levels.

    Animal studies have shown no increased risk of teratogenic effects. There is no adequate information on the use of piracetam in pregnant women to date.


    Piracetam is contraindicated during breastfeeding.

    The manufacturer does not recommend breastfeeding while taking piracetam. A decision to discontinue piracetam therapy or breastfeeding should be made, taking into account the benefits to the child and impact on the parent.

    Piracetam is present in breast milk, but at the time of writing no reports of its use in nursing mothers have been located.

    Side Effects

    Abdominal pain
    Anaphylactoid reaction
    Bleeding disorders
    Exacerbation of epilepsy
    Hypersensitivity reactions
    Loss of balance
    Skin reactions
    Weight gain


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: July 2022.

    Reference Sources

    Summary of Product Characteristics: Nootropil 800mg & 1200mg film-coated tablets. UCB Pharma Ltd. Revised May 2022.

    Summary of Product Characteristics: Nootropil 33% oral solution. UCB Pharma Ltd. Revised May 2022.

    The Renal Drug Handbook. Fifth Edition (2019) ed. Ashley, C. and Dunleavy, A. Radcliffe Publishing Ltd, London.

    NICE Evidence Services
    Available at:
    Last accessed: 20 July 2022.

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    Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content

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    FDB Disclaimer : FDB Multilex is intended for the use of healthcare professionals and is provided on the basis that the healthcare professionals will retain FULL and SOLE responsibility for deciding what treatment to prescribe or dispense for any particular patient or circumstance.