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Piroxicam topical


Gel formulation of piroxicam.

Drugs List

  • FELDENE 0.5% gel
  • piroxicam 0.5% gel
  • Therapeutic Indications


    Osteoarthritis of superficial joints
    Relief of pain and inflammation due to trauma
    Symptomatic relief of pain of the muscles,tendons and joints



    1g of gel (corresponding to 3cm) should be applied to the affected area 3 to 4 times a day.

    The gel should be rubbed in to leave no residual product on the skin.


    Children under 18 years
    Nasal polyps, angioedema, and bronchospastic reactivity to NSAIDs

    Precautions and Warnings

    Renal impairment

    NSAIDs may provoke or exacerbate asthma
    Some formulations contain propylene glycol
    Some presentations may contain benzyl alcohol
    Advise patient to wash hands after use
    Avoid contact with eyes
    Avoid contact with mucous membranes
    Avoid occlusive dressings
    Do not apply to broken or denuded skin
    Monitor skin changes
    Review therapy after 4 weeks
    Discontinue if local irritation occurs
    Discontinue treatment if rash occurs
    Advise patient that photosensitivity possible
    Advise patient to minimise exposure of treated areas to sunlight/sunlamps

    If the patient has developed Stevens-Johnson syndrome or toxic epidermal necrolysis with the use of piroxicam, piroxicam must not be re-started in this patient at any time.

    Pregnancy and Lactation


    Use topical piroxicam with caution in pregnancy.

    The manufacturer states that due to the potential for reproductive toxicity with systemic piroxicam, use of topical piroxicam is not recommended.

    In animals, systemic administration of prostaglandin inhibitors has been shown to adversely affect pregnancy including pre and post implantation loss therefore, as a precaution, use is not recommended.


    Use topical piroxicam with caution in breastfeeding.

    The manufacturer states that safety of topical piroxicam in breastfeeding has not been established and use is not recommended.

    Piroxicam is poorly absorbed from intact skin. Schaefer (2015) suggests that local application of NSAIDs should not prevent breastfeeding.

    Side Effects

    Abdominal pain
    Contact dermatitis
    Drug rash with eosinophilia and systemic symptoms (DRESS)
    Hypersensitivity reactions
    Irritation (localised)
    Stevens-Johnson syndrome
    Toxic epidermal necrolysis


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: February 2019

    Reference Sources

    Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment, 3rd edition (2015) ed. Schaefer, C., Peters, P. and Miller, R. Elsevier, London.

    Summary of Product Characteristics: Feldene Gel. Pfizer Ltd. Revised March 2021.

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    Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content

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    FDB Disclaimer : FDB Multilex is intended for the use of healthcare professionals and is provided on the basis that the healthcare professionals will retain FULL and SOLE responsibility for deciding what treatment to prescribe or dispense for any particular patient or circumstance.