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Prednisolone sodium phosphate ocular preservative free


Preservative free eye drops containing prednisolone sodium phosphate.

Drugs List

  • prednisolone sodium phosphate 0.5% eye drops preservative-free
  • Therapeutic Indications


    Eye - non-infected inflammatory conditions



    Instil 1 or 2 drops into the eye as required.


    Dose is at the discretion of the doctor.


    Ocular infection

    Precautions and Warnings


    Advise patient blurred vision may affect ability to drive/operate machinery
    Treat and control infections prior to commencing therapy
    In combined therapy, administer eye products at least five minutes apart
    To reduce systemic absorption compress lacrimal sac during administration
    Check ocular lens frequently - risk of cataract formation
    Monitor intraocular pressure frequently - risk of steroid glaucoma
    Perform eye tests in any patient with vision change/ophthalmologic symptoms
    Prolonged or high dose may lead to adrenal suppression
    Contains phosphate: Risk of calcification in existing notable cornea damage
    Systemic side effects may occur
    Withdraw gradually after long-term use

    There is an increased risk of adrenal suppression in infants, particularly after prolonged use. In addition, systemic effects may include growth retardation, psychological and behavioural effects in children and adolescents.

    Pregnancy and Lactation


    Use prednisolone sodium phosphate preservative-free eye drops with precaution during pregnancy.

    The manufacturer recommends prednisolone sodium phosphate preservative-free eye drops should be avoided during pregnancy. Animals studies show that topical administration of corticosteroids can cause abnormalities of foetal development, including cleft palate and intrauterine growth retardation. At the time of writing there is limited human data available. There may be a small risk of similar effects in the human foetus.


    Use prednisolone sodium phosphate preservative-free eye drops with caution during breastfeeding.

    There is insufficient information on the excretion of prednisolone sodium phosphate and its metabolites in human milk. Effects on exposed infants are unknown.

    Side Effects

    Adrenal suppression
    Blurred vision
    Increased intra-ocular pressure


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: October 2019

    Reference Sources

    Summary of Product Characteristics: Minims Prednisolone Sodium Phosphate 0.5% w/v, Eye drops solution. Bausch & Lomb U.K. Limited. Revised May 2017.

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    Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content

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    FDB Disclaimer : FDB Multilex is intended for the use of healthcare professionals and is provided on the basis that the healthcare professionals will retain FULL and SOLE responsibility for deciding what treatment to prescribe or dispense for any particular patient or circumstance.