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Progesterone parenteral 25mg/1.112ml

Updated 2 Feb 2023 | Progestogens


Solution for injection containing 25mg progesterone per 1.112ml.

Drugs List

  • LUBION 25mg/1.112ml solution for injection vial
  • progesterone 25mg/1.112ml solution for injection vial
  • Therapeutic Indications


    Luteal support after oocyte retrieval during assisted reproduction



    25mg once daily from the day of oocyte retrieval, usually until 12 weeks of confirmed pregnancy.


    To be given by subcutaneous or intramuscular injection.


    Children under 18 years
    Breast cancer
    Cerebrovascular disorder
    Ectopic pregnancy
    Female genital cancer
    History during pregnancy of pemphigoid gestationis
    History of cholestatic jaundice during pregnancy
    History of pruritus during pregnancy
    History of thromboembolic disorder
    Ischaemic heart disease
    Missed abortion
    Severe hepatic impairment
    Undiagnosed gynaecological haemorrhage
    Venous thromboembolism

    Precautions and Warnings

    Patients over 65 years
    Predisposition to thromboembolic disease
    Tobacco smoking
    Cardiac impairment
    Diabetes mellitus
    Epileptic disorder
    History of severe depression
    Mild hepatic impairment
    Renal impairment
    Severe depression

    Advise ability to drive/operate machinery may be affected by side effects
    Exclude breast cancer before treatment
    Treatment to be prescribed under the supervision of a specialist
    Exclude other causes of infertility before commencing treatment
    Monitor blood glucose closely in patients with diabetes mellitus
    Monitor patients with a history of depression and/or suicide attempts
    Investigate occurrence of visual disturbance or severe headache
    Avoid abrupt withdrawal
    Discontinue at first signs of thrombophlebitis or thromboembolism
    Discontinue if arterial thromboembolism develops
    Discontinue if cerebrovascular disorders occur
    Discontinue if depression worsens or recurs
    Discontinue if first occurrence or worsening of migraine/severe headache
    Discontinue if first occurrence or worsening of visual disturbances
    Discontinue if retinal thrombosis occurs
    Advise patient not to take St John's wort concurrently

    Pregnancy and Lactation


    Progesterone is considered safe for use during pregnancy.

    Progesterone is indicated for luteal support as part of an Assisted Reproductive Technology (ART) treatment program in infertile women.

    There is limited and inconclusive data on the risk of congenital anomalies, including genital abnormalities in male or female infants, following intrauterine exposure during pregnancy. The rates of congenital anomalies, spontaneous abortion and ectopic pregnancies observed during the clinical trial were comparable with the event rate described in the general population, although the total exposure is too low to allow conclusions to be drawn.


    Progesterone is contraindicated during breastfeeding.

    The manufacturer states that progesterone is excreted in human milk and should not be used during breastfeeding.

    LactMed suggests that because of the low levels of progesterone in breastmilk, even with the high-dose products, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.

    Side Effects

    Abdominal distension
    Abdominal pain
    Breast pain
    Breast tenderness
    Feeling hot
    Gastro-intestinal disturbances
    Haematoma (injection site)
    Induration (injection site)
    Injection site reactions
    Mood changes
    Ovarian hyperstimulation syndrome (OHSS)
    Uterine spasm
    Vaginal discharge
    Vaginal haemorrhage
    Vulvovaginal discomfort
    Vulvovaginal itching


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: November 2018

    Reference Sources

    Summary of product characteristics: Lubion 25mg/1.112ml solution for injection. IBSA Farmaceutici Italia Srl. Revised March 2018.
    US National Library of Medicine. Toxicology Data Network. Drugs and Lactation Database (LactMed).

    Available at:
    Progesterone Last revised: 31 October 2018
    Last accessed: 22 November 2018

    NICE Evidence Services Available at: Last accessed: 22 November 2018

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    Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content

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