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Progesterone vaginal capsules

Updated 2 Feb 2023 | Progestogens


Vaginal capsules of progesterone.

Drugs List

  • progesterone 200mg vaginal capsules
  • UTROGESTAN 200mg vaginal capsules
  • Therapeutic Indications


    Luteal supplementation after embryo transfer during assisted reproduction

    Supplementation of the luteal phase during Assisted Reproductive Technology (ART) cycles.



    600mg daily, in three divided doses, from the day of embryo transfer until at least the 7th week of pregnancy and not later than the 12th week of pregnancy.


    Insert deep into the vagina.


    Breast cancer
    Cerebrovascular haemorrhage
    Female genital cancer
    Missed abortion
    Second trimester of pregnancy
    Severe hepatic impairment
    Third trimester of pregnancy
    Thromboembolic disorder
    Undiagnosed gynaecological haemorrhage

    Precautions and Warnings

    History of cholestasis of pregnancy

    Contains soya or soya derivative
    Usual treatment period is up to 12 weeks

    Progesterone vaginal capsules should only be used during the first trimester of pregnancy.

    Use of progesterone after the first trimester increases the risk of cholestasis of pregnancy.

    Pregnancy and Lactation


    Utrogestan is considered safe and it is indicated during the first 12 weeks of pregnancy.

    The manufacturer states that there has been no link between the use of natural progesterone in early pregnancy and effects on foetal development.


    Utrogestan is contraindicated during breastfeeding.

    The manufacturer does not indicate use during breastfeeding. Utrogestan is present in human breast milk.

    Side Effects

    Breast discomfort
    Vaginal discharge
    Vaginal discomfort
    Vaginal haemorrhage


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: May 2019

    Reference Sources

    Summary of product characteristics: Utrogestan Vaginal 200mg capsules. Besins Healthcare (UK) Ltd. Revised April 2019.

    NICE Evidence Services Available at: Last accessed: 20 May 2019

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