Promethazine hydrochloride oral
Presentation
Oral formulations of promethazine hydrochloride.
Drugs List
Dosage
Not all available brands are licensed for all indications.
Individual brands may vary in their dosage recommendations and maximum daily dosage.
Adults
Insomnia
20mg to 50mg at night.
Hypersensitivity reactions
10mg twice a day increasing to a maximum of 20mg three times daily as required or
25mg as a single dose increasing to a maximum of 25mg twice daily as required.
Prevention of motion sickness
20mg to 25mg to be taken the night before the journey. To be repeated after 6 to 8 hours as required.
Children
Children 10 to 18 years
Insomnia
20mg to 50mg at night.
Hypersensitivity reactions
10mg twice a day increasing to a maximum of 20mg three times daily as required or
25mg as a single dose increasing to a maximum of 25mg twice daily as required.
Prevention of motion sickness
20mg to 25mg to be taken the night before the journey. To be repeated after 6 to 8 hours as required.
Children 5 to 10 years
Sedative
20 to 25mg as a single night time dose.
Hypersensitivity reactions
Either 10 to 25mg as a single dose (best taken at night) or 5 to 10mg twice a day. Maximum daily dose 25mg.
Prevention of motion sickness
10mg to be taken the night before the journey. To be repeated after 6 to 8 hours as required.
Children 2 to 5 years
The use of promethazine hydrochloride oral solution is recommended for this age group.
Sedative
15 to 20mg as a single night time dose.
Hypersensitivity reactions
5mg to 15mg as a single dose (best taken at night) or 5mg twice a day. Maximum daily dose 15mg.
Prevention of motion sickness
5mg to be taken the night before the journey. To be repeated after 6-8 hours as required.
Pregnancy and Lactation
Pregnancy
Use promethazine hydrochloride with caution during pregnancy. Promethazine hydrochloride is contraindicated in the 2 weeks prior to delivery.
The manufacturer recommends promethazine hydrochloride is not used during pregnancy unless the potential benefit to the mother outweighs the potential risk to the foetus. However, the manufacturer also recommends that the medication is not used in the 2 weeks prior to delivery as there is a risk of irritability and excitement in the neonate.
Lactation
Use promethazine hydrochloride with caution during breastfeeding.
The manufacture advises that the amount excreted in breast milk is insignificant. However, there is a risk of neonatal irritability and excitement.
Overdosage
It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.
The following number will direct the caller to the relevant local centre (0844) 892 0111
Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ).
Further Information
Last Full Review Date: December 2019
Reference Sources
Summary of Product Characteristics: Phenergan 10mg Tablets. Aventis Pharma Limited, trading as Sanofi. Revised October 2019.
Summary of Product Characteristics: Phenergan 25mg Tablets. Aventis Pharma Limited, trading as Sanofi. Revised October 2019.
Summary of Product Characteristics: Phenergan Night Time 25mg Tablets. Aventis Pharma Limited, trading as Sanofi. Revised October 2019.
Summary of Product Characteristics: Phenergan Elixir. Aventis Pharma Limited, trading as Sanofi. Revised October 2019.
Summary of Product Characteristics: Sominex Tablets. Teva UK Limited. Revised March 2018.
Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content
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