This site is intended for UK healthcare professionals
Medscape UK Univadis Logo
Medscape UK Univadis Logo

Retinol and colecalciferol oral

Updated 2 Feb 2023 | Vitamin A Vitamin D


Oral formulations containing retinol palmitate and colecalciferol.

Drugs List

  • retinol and colecalciferol 4500unit+450unit capsules
  • Therapeutic Indications


    Vitamin A and D deficiency: Prophylaxis



    1 capsule daily. Dosage may be increased to 2 capsules daily if required.


    Children aged over 6 years
    1 capsule daily. Dosage may be increased to 2 capsules daily if required.


    Children under 6 years
    Hypervitaminosis A
    Hypervitaminosis D
    Severe renal impairment

    Precautions and Warnings

    Cardiovascular disorder
    Hepatic impairment
    Renal impairment

    Contains soya or soya derivative
    Breastfeeding: Hypercalcaemia of infant possible if mother taking vitamin D
    Monitor plasma calcium in patients receiving pharmacological doses of drug
    Monitor serum and urinary calcium in patients with sarcoidosis
    Monitor serum calcium levels in patients with renal impairment
    Monitor serum phosphate levels in patients with renal impairment
    Neonate exposed in utero: High doses of vitamin A may be harmful
    Prolonged use or excessive doses may cause hypervitaminosis
    Advise patient not to exceed stated dose

    Risk of cardiac arrhythmias in patients treated with digitalis and other cardiac glycosides. In such cases, strict medical supervision is required and monitor ECG and calcium if necessary.

    Pregnancy and Lactation


    Use retinol and colecalciferol with caution during pregnancy.

    The manufacturer advises that doses of vitamins A and D in excess of those recommended should be avoided during pregnancy unless the clinical condition of the women requires treatment with vitamins A and D.

    Large doses of vitamin A (exceeding 10,000units) have been found to be teratogenic if administered during the first trimester of pregnancy.

    Studies have shown safe use of doses of vitamin D up to 4000units during pregnancy although studies in animals have shown reproductive toxicity.


    Use retinol and colecalciferol with caution during breastfeeding.

    The manufacturer advises that the patient either discontinues from retinol and colecalciferol therapy or discontinues breastfeeding.

    Vitamin A is present in human breast milk. Effects on exposed infants are unknown.

    Vitamin D and its metabolites are excreted in breast milk. Large doses of vitamin D in breastfeeding mothers may cause hypercalcaemia in infants. Doses in excess of those recommended should be avoided during breastfeeding.

    Side Effects

    Decreased appetite
    Hepatic disorders
    Hypervitaminosis A
    Intracranial hypertension
    Skin disorder


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: December 2019

    Reference Sources

    Summary of Product Characteristics: Retinol and Colecalciferol 4500 IU/450 IU Capsules, Soft. Tor Generics Ltd. Revised May 2019.

    Access the full UK drug database with a FREE Medscape UK Account
    It takes just a few minutes, and you’ll get unlimited access to information on over 11,000 UK drugs.
    Register for Free

    Already a member? Log in

    Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content

    FDB Logo

    FDB Disclaimer : FDB Multilex is intended for the use of healthcare professionals and is provided on the basis that the healthcare professionals will retain FULL and SOLE responsibility for deciding what treatment to prescribe or dispense for any particular patient or circumstance.