Rupatadine oral
- Drugs List
- Therapeutic Indications
- Dosage
- Contraindications
- Precautions and Warnings
- Pregnancy and Lactation
- Side Effects
- Monograph
Presentation
Oral formulations of rupatadine.
Drugs List
Therapeutic Indications
Uses
Rhinitis - allergic
Urticaria
Dosage
The medication can be taken with or without food.
Adults
10mg once daily.
Children
Children aged 12 years and over
10mg once daily.
Children aged 2 to 11 years
1mg/ml oral solution
Weighing equal to or more than 25kg: 5mg (5ml) once daily.
Weighing equal to or more than 10kg up to less than 25kg: 2.5mg (2.5ml) once daily.
Contraindications
Children under 2 years
Breastfeeding
Hepatic impairment
Renal impairment
Precautions and Warnings
Children aged 2 to 12 years
Elderly
Galactosaemia
Glucose-galactose malabsorption syndrome
Hereditary fructose intolerance
Lactose intolerance
Pregnancy
Advise ability to drive/operate machinery may be affected by side effects
Not all formulations are suitable for use in children under 12 years
Oral liquid contains hydroxybenzoate: caution in hypersensitivity
Some formulations contain lactose
Some formulations contain sucrose
May potentiate effect of CNS depressants
Advise patient that the effects of alcohol may be potentiated
Grapefruit juice should not be taken simultaneously
Pregnancy and Lactation
Pregnancy
Use rupatadine with caution in pregnancy.
The manufacturer notes that it is preferable to avoid this medication in pregnancy as a precautionary measure.
There is limited data on the use of rupatadine in pregnant women. Animal studies do not indicate any harmful effects either directly or indirectly to the embryonal/foetal development, parturition or postnatal development.
Lactation
Use rupatadine with caution in breastfeeding.
The manufacturer notes a decision should be made whether to cease breastfeeding or stop taking the medication.
Rupatadine is excreted in animal milk but it is unknown whether rupatadine is excreted into breast milk.
Side Effects
Abdominal pain
Abnormal liver function
Alanine aminotransferase increased
Anaphylactic reaction
Angioedema
Arthralgia
Aspartate aminotransferase increased
Asthenia
Attention disturbances
Back pain
Constipation
Cough
Creatine phosphokinase increased
Diarrhoea
Dizziness
Dry mouth
Dry throat
Dyspepsia
Eczema
Eosinophilia
Epistaxis
Fatigue
Headache
Hypersensitivity reactions
Increased appetite
Influenza
Irritability
Malaise
Myalgia
Nasal dryness
Nausea
Neutropenia
Night sweats
Oropharyngeal pain
Palpitations
Pharyngitis
Pyrexia
Rash
Rhinitis
Somnolence
Tachycardia
Thirst
Upper abdominal pain
Urticaria
Vomiting
Weight gain
Overdosage
It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.
The following number will direct the caller to the relevant local centre (0844) 892 0111
Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ).
Further Information
Last Full Review Date: March 2019
Reference Sources
Summary of Product Characteristics: Rupatadine 1mg/ml oral solution. Aspire Pharma Ltd. Revised June 2018.
Summary of Product Characteristics: Rupatadine 10mg tablets. Aspire Pharma Ltd. Revised December 2018.
Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content
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