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Tocofersolan oral

Updated 2 Feb 2023 | Vitamin E


Oral solution containing d-alpha-tocopherol in the form of tocofersolan.

Drugs List

  • tocofersolan 50mg/ml oral solution sugar-free
  • VEDROP 50mg/ml oral solution
  • Therapeutic Indications


    Vitamin E deficiency due to digestive malabsorption in chronic cholestasis


    The dose should be adjusted according to the plasma vitamin E level.


    Total daily dose: 17mg/kg (equivalent to 0.34ml/kg daily of d-alpha-tocopherol in the form of tocofersolan).

    The dose (in ml) can be calculated by dividing the prescribed dose of d-alpha-tocopherol (in mg) by 50.


    Adults aged 18 years and above
    Premature infants

    Precautions and Warnings

    High predisposition to thrombosis
    Hepatic impairment
    Renal impairment

    Treatment to be initiated and supervised by a specialist
    Contains hydroxybenzoate
    Monitor plasma Vitamin E levels initially monthly then at regular intervals
    Monitor hepatic function in patients with hepatic impairment
    Monitor prothrombin time in vitamin K deficient patients
    Monitor prothrombin times closely in patients on anticoagulant therapy
    Monitor renal function in patients with renal impairment

    Pregnancy and Lactation


    Tocofersolan should be used with caution in pregnancy.

    No clinical data on exposed pregnancies are available for tocofersolan. Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/foetal development, parturition or post-natal development.

    The manufacturer advises caution should be used when prescribing to pregnant women.


    Tocofersolan should be used with caution in breastfeeding.

    It is not known if tocofersolan is excreted in human breast milk or animal milk.

    The manufacturer advises a decision on whether to continue/discontinue breast-feeding or to continue/discontinue therapy with tocofersolan should be made taking into account the benefit of breast-feeding to the child and the benefit of tocofersan therapy to the woman.

    Side Effects

    Abdominal pain
    Abnormal serum sodium levels
    Fluctuating serum potassium levels
    Increase in serum transaminases
    Increased bleeding tendency


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: April 2019.

    Reference Sources

    Summary of Product Characteristics: Vedrop 50mg/ml oral solution. Orphan Europe (UK) Limited. Revised October 2017.

    NICE Evidence Services Available at: Last accessed: 1 April 2019

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