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Triamcinolone hexacetonide injection


Triamcinolone hexacetonide suspension for injection

Drugs List

  • triamcinolone hexacetonide 20mg/1ml injection
  • Therapeutic Indications


    Juvenile idiopathic arthritis
    Rheumatoid arthritis


    Asepsis must be observed in the use of this product. The vial should be shaken carefully before use to ensure suspension. The injection site should be sterilised using the same technique as with lumbar puncture. At each treatment session, an injection may be given into two joints at the most.


    Intraarticular injection for all indications in adults and children of 12 years and older. The dose 2 to 20 mg is determined individually according to the size of the joint and the amount of articular fluid. Large joints (e.g. hip, knee, shoulder) generally require 10 to 20 mg (0.5 to 1 ml), medium-sized joints 5 to 10 mg (0.25 to 0.5 ml), and smaller joints 2 to 6 mg (0.1 to 0.3 ml). If there is a lot of articular fluid, it can be aspirated prior to administration of the drug. The next dose and the number of injections depend on the progress of the clinical condition. Because Triamcinolone hexacetonide is long acting, administration of injections into individual joints more frequently than at 3 to 4 week intervals is not recommended. Accumulation of the drug at the injection site must be avoided, because it may cause atrophy.

    Periarticular injection dosage for adults and children of 12 years and older. Bursitis/Epicondylitis: Generally 10 to 20 mg (0.5 to 1 ml) depending on the size of the bursa and the severity of the disease. In the majority of cases a single treatment is sufficient. Synovitis/Tendinitis: Generally 10 to 20 mg (0.5 to 1 ml). The need for additional injections should be determined on the basis of response to treatment.


    Dosage for intraarticular use in children aged from 3 to 12 years with Juvenile Idiopathic Arthritis. The dosage regime for triamcinolone hexacetonide intraarticular injection for JIA in children is 1 mg/kg for large joints (knees, hips, and shoulders) and 0.5 mg/kg for smaller joints (ankles, wrists, and elbows). For the hands and feet, 1 to 2 mg/joint for metacarpophalangeal/metatarsophalangeal (MCP/MTP) joints, and 0.6 to 1 mg/joint for proximal interphalangeal (PIP) joints may be used.


    Children under 3 years
    Uncontrolled systemic infection
    Acute psychosis
    Hereditary fructose intolerance
    Herpes simplex keratitis

    Precautions and Warnings

    Children under 12 years
    Exanthematous disorder
    Acute glomerulonephritis
    Cardiac failure
    Chronic nephritis
    Cushing's disease
    Diabetes mellitus
    Gastric ulcer
    Latent or healed tuberculosis
    Metastatic carcinoma
    Myasthenia gravis
    Recent gastrointestinal anastomosis
    Renal impairment
    Thromboembolic disorder
    Ulcerative colitis

    Adjustment of hypoglycaemic therapy may be necessary in diabetes mellitus
    Administration of live vaccines is not recommended
    May mask symptoms or signs of infections
    Exclude fungal infection before treatment
    Exclude joint infection before injection
    Not all routes are licensed for all indications
    Contains benzyl alcohol
    Contains polysorbate
    Presentations with sorbitol unsuitable in hereditary fructose intolerance
    Do not inject into unstable joints
    Maximum of two joints to be treated in one session
    Monitor growth and development in children on prolonged therapy
    Adrenal cortical atrophy may persist for years after stopping drug
    Antibody response to non-live vaccines may be diminished
    Discontinue if active infection develops
    May precipitate diabetes mellitus
    Use of live vaccines may cause severe reaction
    May affect results of some laboratory tests
    Do not withdraw this drug suddenly
    Discontinue if serious allergic or anaphylactic reaction occurs
    Maintain treatment at the lowest effective dose
    Not licensed for all indications in all age groups
    Avoid prolonged use
    Advise patient not to take NSAIDs unless advised by clinician
    Advise patient not to take St John's wort concurrently
    Advise patient not to overuse joints even if symptomatic benefit is felt
    Advise those on systemic corticosteroids to avoid chickenpox/H zoster
    Ensure patient receives Steroid Treatment/Steroid Emergency Card
    If exposed to chickenpox or Herpes zoster seek urgent medical attention

    Pregnancy and Lactation


    Use triamcinolone hexacetonide with caution in pregnancy.

    Triamcinolone crosses the placenta. Corticosteroids are teratogenic in animal experiments. The significance of this fact for humans is not exactly known, but so far the use of corticosteroids has not been shown to increase the incidence of malformations. Long-term use of corticosteroids in humans and animals has led to a decrease in weight of the placenta and the newborn. Long term corticosteroid therapy is also associated with a risk of adrenocortical suppression in the newborn. The product should be used during pregnancy only if the benefit to the mother is clearly greater than the risk to the fetus.
    The use of all medication in pregnancy should be avoided whenever possible; particularly in the first trimester. Non-drug treatments should also be considered. When essential, a medication with the best safety record over time should be chosen, employing the lowest effective dose for the shortest possible time. Polypharmacy should be avoided. Teratogens taken in the pre-embryonic period, often quoted as lasting until 14 to 17 days post-conception, are believed to have an all-or-nothing effect. Where drugs have a short half-life, and when the date of conception is certain, this may allow women to be reassured where drug exposure has occurred within this time frame. Further advice may be available from the UK National Teratology Information Service (NTIS) and through ToxBase, available via password on the internet ( ) or if this is unavailable at the backup site ( ).


    Use triamcinolone hexacetonide with caution in breastfeeding.

    Triamcinolone hexacetonide is excreted in human milk, local injections, such as for tendinitis, would not be expected to cause any adverse effects in breastfed infants, but might occasionally cause temporary loss of milk supply. Caution must be observed in the long-term use of large doses. Neonates, infants born prematurely, those with low birth weight, those with an unstable gastrointestinal function or who have serious illnesses may require special consideration. For any infant, if a drug is prescribed to the nursing mother, it should be at the lowest practical dose and for the shortest time. When drug administration is unavoidable and breastfeeding is to continue, minimisation of exposure of the infant to the drug may sometimes be achieved by timing the maternal doses to just after a feeding episode. Infants exposed to drugs via breast milk should be monitored for unusual signs or symptoms. Interactions between the drug received by the infant from the mother's milk and medication prescribed for the infant should also be considered, for example, when the drug given to the infant may prevent metabolism of the drug received via breast milk.
    Specialist advice is available from the UK Drugs in Lactation Advisory Service at


    Athletes should be informed that this medicinal product contains an ingredient (triamcinolone hexacetonide) that may produce a positive result in anti-doping tests.

    Side Effects

    Abscess (sterile)
    Acneform changes
    Aggravation of pre-existing psychiatric conditions
    Aseptic necrosis
    Atrophy (localised)
    Calcinosis (injection site)
    Cardiac failure
    Charcot-like arthropathy
    Cushing's syndrome
    Diabetes mellitus
    Erythema at injection site
    Exacerbation of infection
    Facial erythema
    Growth retardation (children)
    Increased intra-ocular pressure
    Local pain (injection site)
    Menstrual disturbances
    Mood changes
    Necrosis (injection site)
    Negative nitrogen balance
    Peptic ulceration
    Peptic ulceration with perforation and haemorrhage
    Posterior subcapsular cataracts
    Psychotic symptoms
    Raised intracranial pressure
    Reduced carbohydrate tolerance
    Reduced muscle mass
    Secondary adrenocortical and pituitary unresponsiveness
    Swelling (injection site)
    Tendon rupture
    Thinning of skin
    Wound healing retarded

    Effects on Laboratory Tests

    Corticosteroids may interfere with the nitroblue tetrazolium test for bacterial infection, producing false-negative results.


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: September 2014

    Reference Sources

    Joint Formulary Committee. British National Formulary(online) London: BMJ Group and Pharmaceutical Press Accessed on 18th September, 2014.

    Summary of Product Characteristics: Triamcinolone Hexacetonide 20 mg/ml suspension for injection. Intrapharm Laboratories Ltd. Revised June 2014.

    US National Library of Medicine. Toxicology Data Network. Drugs and Lactation Database (LactMed).
    Available at:
    Triamcinolone Last revised: 16th January, 2014
    Last accessed: 18th September, 2014

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    Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content

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