Triamterene with chlortalidone oral
- Drugs List
- Therapeutic Indications
- Precautions and Warnings
- Pregnancy and Lactation
- Side Effects
Oral formulations of triamterene with chlortalidone.
Ascites and oedema associated with hepatic cirrhosis
Oedema due to cardiac failure
Oedema due to corticosteroid treatment
Oedema due to nephrotic syndrome
Oedema due to oestrogen treatment
Treatment of mild to moderate essential hypertension
1 tablet daily after breakfast. Dose maybe increased to 2 tablets once daily if required.
1 tablet daily after breakfast. If oedema persists after 7 to 10 days then dose maybe increased to 2 tablets once daily.
Children under 18 years
Progressive renal disorder
Renal impairment - creatinine clearance below 30 ml/minute
Severe hepatic impairment
Precautions and Warnings
Glucose-galactose malabsorption syndrome
Systemic lupus erythematosus
Diabetic control may need adjustment
Monitor fluid and electrolyte status
Monitor patients at risk of gout
Monitor serum potassium periodically
May cause hyperuricaemia
May decrease serum protein bound iodine w/o signs of thyroid disturbance
May exacerbate diabetes mellitus
May impart blue colour to urine
May precipitate diabetes mellitus
May precipitate gout
Discontinue if hyperkalaemia occurs
Discontinue or reduce dose if renal impairment worsens
Consider reducing initial dose in the elderly
Advise patient to moderate alcohol intake during treatment
Advise on problems of salt substitutes/high intake of potassium-rich food
Pregnancy and Lactation
Triamterene with chlortalidone is contraindicated during pregnancy.
The manufacturer does not recommend using triamterene with chlortalidone during pregnancy unless essential. At the time of writing there is limited published information regarding the use of triamterene with chlortalidone during pregnancy. Potential risks are unknown.
Triamterene and chlortalidone is contraindicated during breastfeeding.
The manufacturer does not recommend breastfeeding whilst taking triamterene with chlortalidone. Thiazide diuretics have been shown to be expressed in human breast milk but the quantity is unknown. Thrombocytopenia, pancreatitis or hypokalaemia have been reported in exposed infants.
It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.
The following number will direct the caller to the relevant local centre (0844) 892 0111
Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ).
Last Full Review Date: February 2020
Summary of Product Characteristics: Triamterene/Chlortalidone tablets. DHP Healthcare Ltd. Revised April 2019.
NICE Evidence Services Available at: www.nice.org.uk Last accessed: 12 February 2020
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