Typhoid vaccine parenteral
- Drugs List
- Therapeutic Indications
- Dosage
- Administration
- Contraindications
- Precautions and Warnings
- Pregnancy and Lactation
- Side Effects
- Monograph
Presentation
Parenteral vaccine containing Salmonella typhi (Ty2 strain).
Drugs List
Therapeutic Indications
Uses
Vaccination against typhoid fever
Active immunisation against typhoid fever.
For comprehensive information or advice on this product or the immunisation programme in the UK, the following website should be accessed.
https://www.gov.uk/government/collections/immunisation-against-infectious-disease-the-green-book
Dosage
Adults
A single 0.5ml dose.
The vaccine should be administered at least 2 weeks before the risk of exposure to typhoid fever.
Revaccination
In patients who remain at risk of exposure to typhoid fever, single doses may be given at three yearly intervals.
Children
Children aged 2 years to 18 years of age
A single 0.5ml dose.
The vaccine should be administered at least 2 weeks before the risk of exposure to typhoid fever.
Revaccination
In patients who remain at risk of exposure to typhoid fever, single doses may be given at three yearly intervals.
Children aged 12 months to 2 years of age (unlicensed)
There may be a sub-optimal response to the vaccine in patients younger than 2 years. The decision to vaccinate infants aged 1 year to 2 years old should be based on the risk of exposure to the disease. Immunisation is not recommended in infants under 12 months.
A single 0.5ml dose.
The vaccine should be administered at least 2 weeks before the risk of exposure to typhoid fever.
Administration
For deep subcutaneous or intramuscular injection.
Contraindications
Children under 1 year
Severe febrile conditions
Precautions and Warnings
Children aged 1 to 2 years
Immunosuppression
Breastfeeding
Coagulopathy
Immunodeficiency syndromes
Pregnancy
Thrombocytopenia
Postpone immunisation if there is active or suspected infection
Advise ability to drive/operate machinery may be affected by side effects
Child under 2 years: Sub-optimal immune response to polysaccharide vaccine
Impaired response possible in immunocompromised patients
Vaccine may not be effective in 100% of patients
May contain trace amounts of formaldehyde
Inject other vaccines at different sites
Resuscitation facilities must be immediately available
Use only if the solution is clear and colourless
Establish full medical history and health status prior to vaccine
Follow national immunisation guidelines
Prior to administration, a full medical history, current health status and any adverse events after previous immunisations should be checked. In subjects who have a history of serious or severe reaction within 48 hours of a previous injection with a vaccine containing similar components, the need for the vaccination must be carefully considered following a risk-benefit assessment.
Vaccination should be postponed in patients suffering from acute febrile illness. The presence of minor infection is not a contraindication.
Vaccination may not result in protection in all vaccinees. Travellers should be advised to take all necessary precautions to avoid contact with or ingestion of potentially contaminated food or water.
This typhoid vaccine does NOT protect against disease caused by Salmonella paratyphi or other non-typhoidal Salmonellae.
Typhoid vaccination is not a substitute for scrupulous personal hygiene.
Syncope may occur following, or even before, any vaccination especially in adolescents as a psychogenic response to the needle injection. This can be accompanied by several neurological signs such as transient visual disturbances, paraesthesia and tonic-clonic limb movements during recovery. It is important that procedures are in place to avoid injury from faints.
Pregnancy and Lactation
Pregnancy
Use parenteral typhoid vaccine with caution during pregnancy.
The manufacturer does not recommend using parenteral typhoid vaccine during pregnancy. At the time of writing there is limited published information regarding the use of parenteral typhoid vaccine during pregnancy. Potential risks are unknown. The advice from the Green Book is that vaccination should be considered if the risk of typhoid is high. Experience shows that vaccination with inactivated toxoids does not pose any significant risk to mother or foetus (Green Book).
Lactation
Use parenteral typhoid vaccine with caution during breastfeeding.
The manufacturer advises caution if parenteral typhoid vaccine is used when breastfeeding. There is limited published information on the use of parenteral typhoid vaccine during breastfeeding. The presence of parenteral typhoid vaccine in human breast milk is unknown. Effects on exposed infants are unknown. Experience shows that vaccination with inactivated toxoids does not pose any significant risk to the nursing mother or her infant (Green Book).
Side Effects
Abdominal pain
Allergic reaction
Anaphylactoid reaction
Anaphylaxis
Arthralgia
Asthenia
Asthma
Back pain
Chills
Decreased appetite
Diarrhoea
Erythema at injection site
Fatigue
Fever
Flatulence
Headache
Hypersensitivity reactions
Induration (injection site)
Influenza-like symptoms
Malaise
Myalgia
Nausea
Pain / soreness (injection site)
Paraesthesia
Pruritus
Rash
Serum sickness
Shock
Syncope
Urticaria
Visual disturbances
Vomiting
Overdosage
It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.
The following number will direct the caller to the relevant local centre (0844) 892 0111
Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ).
Further Information
Last Full Review Date: January 2020
Reference Sources
Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment, 3rd edition (2015) ed. Schaefer, C., Peters, P. and Miller, R. Elsevier, London.
Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 10th edition (2015) ed. Briggs, G., Freeman, R. Wolters Kluwer Health, Philadelphia.
Summary of Product Characteristics: Typhim Vi. Sanofi Pasteur MSD Ltd. Revised August 2019.
Immunisation against infectious disease - The Green Book.
Available at https://www.gov.uk/government/collections/immunisation-against-infectious-disease-the-green-book
Last accessed: 27 January 2020.
NICE Evidence Services Available at: www.nice.org.uk Last accessed: 27 January 2020.
US National Library of Medicine. Toxicology Data Network. Drugs and Lactation Database (LactMed).
Available at: https://www.ncbi.nlm.nih.gov/books/NBK501922/
Typhoid vaccine. Last revised: 31 October 2018.
Last accessed: 29 January 2020.
Medscape UK | Univadis prescription drug monographs & interactions are based on FDB Multilex Content
FDB Disclaimer : FDB Multilex is intended for the use of healthcare professionals and is provided on the basis that the healthcare professionals will retain FULL and SOLE responsibility for deciding what treatment to prescribe or dispense for any particular patient or circumstance.