Umeclidinium with vilanterol inhalation
- Drugs List
- Therapeutic Indications
- Precautions and Warnings
- Pregnancy and Lactation
- Side Effects
Inhalation powder containing umeclidinium bromide and vilanterol (as trifenatate).
Chronic obstructive pulmonary disease
One inhalation once daily, at the same time of the day to maintain bronchodilation.
Maximum dose is one inhalation.
Children under 18 years
Precautions and Warnings
Benign prostatic hyperplasia
Bladder outflow obstruction
Glucose-galactose malabsorption syndrome
Narrow angle glaucoma
Severe cardiovascular disorder
Severe hepatic impairment
Ensure patient has a fast acting bronchodilator available
Check patient is using correct inhaler technique
Monitor blood glucose closely in patients with diabetes mellitus
Monitor serum K+ in patients on high dose steroids/xanthines/diuretics
May reduce serum potassium levels
Discontinue if paradoxical bronchospasm occurs
Advise patient not to use for relief of acute attacks
Advise patient to seek medical advice if treatment is ineffective
Use regularly to maintain freedom from symptoms
Pregnancy and Lactation
Use umeclidinium with vilanterol with caution during pregnancy.
The manufacturer recommends that this medication should be used during pregnancy only if the expected benefit to the mother justifies the potential risk to the foetus.
There is no data from the use of umeclidinium with vilanterol. Studies in animals have shown reproductive toxicity at exposures which are not clinically relevant after administration of vilanterol.
Umeclidinium with vilanterol is contraindicated during breastfeeding.
The manufacturer advises discontinuing breastfeeding or discontinuing umeclidinium with vilanterol treatment.
It is unknown whether umeclidinium or vilanterol are excreted in human milk. However, other beta2-adrenergic agonists are detected in human milk. A risk to the newborns/infants cannot be excluded.
Bladder outflow obstruction
Increased intra-ocular pressure
Upper respiratory tract infection
Urinary tract infections
It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.
The following number will direct the caller to the relevant local centre (0844) 892 0111
Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( www.toxbase.org ) or if this is unavailable at the backup site ( www.toxbasebackup.org ).
Last Full Review Date: January 2021
Summary of Product Characteristics: Anoro Ellipta 55 micrograms/22 micrograms dry powder inhaler. GlaxoSmithKline UK. Revised September 2019.
NICE Evidence Services Available at: www.nice.org.uk Last accessed: 21 January 2021
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