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Verapamil hydrochloride modified release oral


Modified release formulations of verapamil hydrochloride

Drugs List

  • HALF SECURON SR 120mg tablets
  • SECURON SR 240mg tablets
  • verapamil 120mg modified release tablet
  • verapamil 240mg modified release tablet
  • VERAPRESS 240mg modified release tablet
  • VERA-TIL SR 120mg tablets
  • VERA-TIL SR 120mg tablets
  • VERA-TIL SR 240mg tablets
  • VERA-TIL SR 240mg tablets
  • Therapeutic Indications


    Hypertension - mild to moderate
    Prophylaxis of angina pectoris
    Secondary prevention of reinfarction after MI in suitable pts. without CCF
    Treatment of angina pectoris

    Treatment and prophylaxis of angina pectoris.

    Treatment of mild to moderate hypertension.

    Secondary prevention of reinfarction after an acute myocardial infarction in patients without heart failure, and not receiving diuretics (apart from low-dose diuretics when used for indications other than heart failure), and where beta-blockers are not appropriate. Treatment is to be started at least one week after an acute myocardial infarction.



    240mg once daily.
    For patients new to verapamil, an initial dose of 120mg should be considered.
    If control is not achieved after one week, the dose may be increased up to a maximum of 480mg daily in divided doses, with a twelve hour dose interval (some brands recommend 480mg once daily).

    Angina pectoris
    360mg daily in one or two divided doses, increasing up to a maximum of 240mg twice daily or 480mg once daily if necessary. A small number of patients respond to a lower dose and where indicated adjustment down to 240mg once daily could be made.

    Secondary prevention of reinfarction
    For patients who have experienced an acute myocardial infarction, without heart failure and are not receiving diuretics (apart from low-dose diuretics when used for indications other than heart failure), and where beta blockers are not appropriate:
    Start treatment at least 1 week after acute myocardial infarction using a dose of 360mg daily in divided doses either as:
    120mg modified release tablet, three times daily
    240mg modified release tablet in the morning and 120mg modified release tablet in the evening.

    Patients with Hepatic Impairment

    The dosage may need to be adjusted in patients with hepatic impairment and initial doses should be low.

    Verapamil hydrochloride is extensively metabolised by the liver and thus patients with hepatic impairment may experience delayed metabolism of the drug. This delay may be to a greater or lesser extent depending on the severity of hepatic impairment. Consequently, the effects of verapamil hydrochloride may be potentiated and/or prolonged.


    Systolic blood pressure < 90mmHg
    Bradycardia - if treating myocardial infarction
    Bradycardia with pulse rate at rest < 50 beats per minute
    Cardiogenic shock
    Decompensated cardiac failure
    First trimester of pregnancy
    Hereditary fructose intolerance
    History of cardiac failure
    Hypotension - if treating myocardial infarction
    Left ventricular dysfunction - if treating myocardial infarction
    Lown-Ganong-Levine syndrome
    Non paced second/third degree AV block
    Non-paced sinus node dysfunction
    Severe left ventricular failure
    Sinoatrial exit block
    Wolff-Parkinson-White syndrome

    Precautions and Warnings

    Children under 18 years
    Duchenne muscular dystrophy
    First degree atrioventricular block
    Glucose-galactose malabsorption syndrome
    Hepatic impairment
    Lactose intolerance
    Myasthenia gravis
    Myasthenic Eaton-Lambert syndrome
    Myocardial infarction
    Renal impairment
    Second trimester of pregnancy
    Third trimester of pregnancy

    Control cardiac failure before starting treatment
    Not removed via dialysis
    Reduce dose in patients with hepatic impairment
    Advise ability to drive/operate machinery may be affected by side effects
    Not all available brands are licensed for all indications
    Some formulations contain lactose
    Monitor blood pressure regularly
    May precipitate or aggravate cardiac failure even in controlled cases
    Pregnancy: This medication may inhibit labour
    Withdraw gradually after long-term use
    Bioavailability differs with preparations;caution on changing formulations
    Advise patient not to take aspirin unless advised by clinician
    Advise patient not to take simvastatin unless advised by clinician
    Advise patient not to take St John's wort concurrently
    Advise patient that this medication may prolong the effects of alcohol
    Advise patient grapefruit products may increase plasma level

    Ventricular tachycardia may be precipitated in patients with atrial flutter or fibrillation in association with an accessory pathway (e.g. Wolff-Parkinson-White syndrome).

    Pregnancy and Lactation


    Verapamil is contraindicated in the first trimester of pregnancy.

    Use during the second and third trimesters of pregnancy only if essential and the benefits to the mother outweigh the potential risks to the foetus.

    There is limited data available regarding the use of verapamil hydrochloride in pregnancy. Animal studies have not shown any teratogenic effects. Schaefer (2015) states that use can cause hyperprolactinaemia and galactorrhoea.

    The use of all medication in pregnancy should be avoided whenever possible; particularly in the first trimester. Non-drug treatments should also be considered. When essential, a medication with the best safety record over time should be chosen, employing the lowest effective dose for the shortest possible time. Polypharmacy should be avoided. Teratogens taken in the pre-embryonic period, often quoted as lasting until 14 to 17 days post-conception, are believed to have an all-or-nothing effect. Where drugs have a short half-life, and when the date of conception is certain, this may allow women to be reassured where drug exposure has occurred within this time frame. Further advice may be available from the UK National Teratology Information Service (NTIS) and through ToxBase, available via password on the internet ( ) or if this is unavailable at the backup site ( ).


    Use verapamil hydrochloride with caution in breastfeeding.

    Verapamil hydrochloride is excreted in breast milk in small amounts and is unlikely to be harmful. Limited human data from the oral dose has shown the infant relative dose is low (0.1 to 1% of the mother's oral dose). LactMed states that verapamil would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months.

    Due to the potential for serious adverse reactions in nursing infants, verapamil hydrochloride should only be used in breastfeeding if clearly necessary.

    Neonates, infants born prematurely, those with low birth weight, those with an unstable gastrointestinal function or who have serious illnesses may require special consideration. For any infant, if a drug is prescribed to the nursing mother, it should be at the lowest practical dose and for the shortest time. When drug administration is unavoidable and breastfeeding is to continue, minimisation of exposure of the infant to the drug may sometimes be achieved by timing the maternal doses to just after a feeding episode. Infants exposed to drugs via breast milk should be monitored for unusual signs or symptoms. Interactions between the drug received by the infant from the mother's milk and medication prescribed for the infant should also be considered, for example, when the drug given to the infant may prevent metabolism of the drug received via breast milk.
    Specialist advice is available from the UK Drugs in Lactation Advisory Service at

    Side Effects

    Abdominal pain
    Aggravation of cardiac failure
    Allergic reaction
    Ankle oedema
    Bradyarrhythmia in atrial fibrillation
    Cardiac failure
    Erythema multiforme
    Extrapyramidal effects
    Gingival hyperplasia
    Gynaecomastia in older men
    Increase in alkaline phosphatase
    Increase in serum transaminases
    Increased prolactin
    Liver function disturbances
    Muscle weakness
    Peripheral oedema
    Quincke's oedema
    Second and third degree AV block
    Sinus arrest with asystole
    Sinus bradycardia
    Stevens-Johnson syndrome


    It is strongly recommended that the UK National Poisons Information Service be consulted on cases of suspected or actual overdose where there is doubt over the degree of risk or about appropriate management.

    The following number will direct the caller to the relevant local centre (0844) 892 0111

    Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. This is available via password on the internet ( ) or if this is unavailable at the backup site ( ).

    Further Information

    Last Full Review Date: August 2018

    Reference Sources

    Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 10th edition (2015) ed. Briggs, G., Freeman, R. Wolters Kluwer Health, Philadelphia.

    Summary of Product Characteristics: Half Securon SR. Mylan Ltd. Revised May 2017.

    Summary of Product Characteristics: Securon SR. Mylan Products Ltd. Revised May 2017.

    Summary of Product Characteristics: Vertab SR 240 Tablets. Dexcel-Pharma Ltd. Revised July 2013.

    Summary of Product Characteristics: Vera-Til SR 120mg Tablets. Tillomed Laboratories Ltd. Revised January 2018.
    Summary of Product Characteristics: Vera-Til SR 240mg Tablets. Tillomed Laboratories Ltd. Revised February 2018.

    NICE Evidence Services Available at: Last accessed: 16 August 2018

    US National Library of Medicine. Toxicology Data Network. Drugs and Lactation Database (LactMed).
    Available at:
    Verapamil. Last revised: 10 March, 2015
    Last accessed: 16 August 2018

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