This site is intended for
Adiposity and the Risk of Major Stroke Types
- Body mass index (BMI) was associated with a lower risk of intracerebral and subarachnoid haemorrhage but not with the risk of ischaemic stroke.
- Waist circumference was associated with an increased risk of ischaemic stroke and intracerebral haemorrhage but not with the risk of subarachnoid haemorrhage.
Why This Matters
- Findings highlight the significance of considering body fat distribution when assessing stroke risk.
- A large prospective cohort study of 490,071 participants (age 40-69 years) without stroke, identified from the UK Biobank (2006-2010).
- Funding: Core grants to Clinical Trial Service Unit from the Medical Research Council and others.
- During a median follow-up of 12 years, 7117, 1391, and 834 events of incident ischaemic strokes, intracerebral haemorrhages, and subarachnoid haemorrhages, respectively, were reported.
- BMI was associated with a lower risk of (adjusted HR [aHR] per 5-unit higher BMI; 95% CI):
- intracerebral haemorrhage (0.85; 0.74 to 0.96); and
- subarachnoid haemorrhage (0.82; 0.69 to 0.96).
- There was no association between BMI and the ischaemic stroke risk (aHR per 5-unit higher BMI 1.04; 95% CI 0.97 to 1.11).
- Waist circumference was associated with a higher risk of (aHR per 10-cm higher waist circumference; 95% CI):
- intracerebral haemorrhage (1.17; 1.05 to 1.30); and
- ischaemic stroke (1.19; 1.13 to 1.25).
- No association was observed between waist circumference and subarachnoid haemorrhage risk (aHR per 10-cm higher waist circumference 1.07; 95% CI 0.93 to 1.22).
- Observational design.
- Risk of residual confounding.