Takeaway
- Body weight variability was found to be associated with a higher risk of cardiovascular events, cardiovascular death, myocardial infarction, stroke, and composite cardiovascular disease (CVD) outcomes, independent of diabetes status and ethnicity.
Why This Matters
- Findings suggest that investigation of the biological mechanism and identification of weight variability biomarkers may be helpful in identifying individuals most at risk of CVD.
Study Design
- A meta-analysis of 23 studies including 15,382,537 participants, identified after a search across PubMed, Web of Science, and Cochrane Library databases.
- Primary outcome: the risk of any cardiovascular event.
- Secondary outcomes: cardiovascular death, myocardial infarction, stroke, and composite CVD outcomes.
- Funding: None.
Key Results
- Body weight variability was associated with a significantly increased risk of (relative risk; 95% CI):
- any cardiovascular event (1.27; 1.17 to 1.38; I2 97.28%; P<0.0001);
- cardiovascular death (1.29; 1.03 to 1.60; I2 55.16%; P<0.0001);
- myocardial infarction (1.32; 1.09 to 1.59; I2 97.14%; P=0.0037);
- stroke (1.21; 1.19 to 1.24; P<0.0001); and
- composite CVD outcomes (1.36; 1.08 to 1.73; I2 92.41%; P=0.01).
- This association was not modified by ethnicity or diabetes status.
- Similar results were observed for body mass index variability and per unit standard deviation increase in body weight variability.
Limitations
- Heterogeneity among studies.
References
References
