Clinical Summary

Does Dynapaenia Modify Fracture Risk in Women With Obesity?

Vinod Rane, BS Pharm | Disclosures

Takeaway

Dynapaenia was associated with a greater risk of lower extremity (ankle and leg) fractures in women with obesity, irrespective of bone mineral density.
Dynapaenia neutralised the protective effects of obesity on the fracture risk of the wrist, arm, hip, spine, and other bones.

Findings may have important clinical implications for identifying and preventing the risk of falls and fractures in a growing population with overweight and obesity.

This large, cross-sectional, retrospective study included 16,147 women (age 60-82 years) from the UK Biobank (2006-2010) who were categorised according to the dynapaenia status (lowest tertile of handgrip strength ≤21 kg) and body mass index categories (normal weight, overweight, and obesity).
Funding: Medical Research Council and others.

Of 16,147 women, 3793 (23.5%) women fell, of whom 1062 reported more than one fall.
Overall, 1413 out of 15,570 (9.1%) eligible women reported fracture because of a fall.
Compared with people with normal weight, those with overweight and obesity had a significantly higher risk of lower extremity fractures, with the risk being significantly greater in people with obesity (adjusted OR [aOR] 2.08; 95% CI 1.39 to 3.11) or with dynapaenic obesity (aOR 2.78; 95% CI 1.77 to 4.37).
People with obesity had a lower risk of fractures of the wrist, arm, hip, spine, and other bones (aOR 0.77; 95% CI 0.61 to 0.96), except for those with low handgrip strength, who had a similar fracture risk to those with normal weight (aOR 1.06; 95% CI 0.82 to 1.38).