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Does T2D Modify the Association Between Glucosamine and Dementia Risk?
- Habitual use of glucosamine was significantly associated with a reduced risk of dementia, and this association was mediated by the incidence of type 2 diabetes (T2D).
Why This Matters
- Growing evidence has demonstrated an association between habitual glucosamine use and T2D.
- However, the effect of habitual use of glucosamine on the risk of dementia is still unknown.
- This prospective cohort study included 495,942 participants (age, 37-73 years) using data from the UK Biobank (2006-2010).
- Primary outcome: incidence of dementia.
- Secondary outcome: Alzheimer’s disease and vascular dementia.
- Funding: National Natural Science Foundation of China and Scientific Research Foundation for Scholars of Hangzhou Normal University.
- Of 495,942 participants, 401,444 (80.94%) were using glucosamine supplements and 94, 498 (19.05%) were not.
- During a median follow-up of 11 years, 6831 dementia events were reported, including 1790 events of Alzheimer’s disease and 923 events of vascular dementia.
- Habitual glucosamine use was linked to a significantly lower risk of dementia (adjusted HR [aHR] 0.87; 95% CI 0.82 to 0.93).
- Glucosamine users vs non-users had a lower risk of incident vascular dementia (aHR 0.82; 95% CI 0.69 to 0.98).
- No significant association was observed between glucosamine use and Alzheimer’s disease risk (aHR 0.97; 95% CI 0.86 to 1.08).
- Glucosamine use was associated with a lower risk of dementia in patients with T2D over the follow-up (aHR 0.79; 95% CI 0.67 to 0.93).
- Observational design.
- Risk of unmeasured confounding.