Clinical Summary

Does T2D Modify the Association Between Glucosamine and Dementia Risk?

Vinod Rane, BS Pharm | Disclosures

Takeaway

Habitual use of glucosamine was significantly associated with a reduced risk of dementia, and this association was mediated by the incidence of type 2 diabetes (T2D).

Growing evidence has demonstrated an association between habitual glucosamine use and T2D.
However, the effect of habitual use of glucosamine on the risk of dementia is still unknown.

This prospective cohort study included 495,942 participants (age, 37-73 years) using data from the UK Biobank (2006-2010).
Primary outcome: incidence of dementia.
Secondary outcome: Alzheimer’s disease and vascular dementia.
Funding: National Natural Science Foundation of China and Scientific Research Foundation for Scholars of Hangzhou Normal University.

Of 495,942 participants, 401,444 (80.94%) were using glucosamine supplements and 94, 498 (19.05%) were not.
During a median follow-up of 11 years, 6831 dementia events were reported, including 1790 events of Alzheimer’s disease and 923 events of vascular dementia.
Habitual glucosamine use was linked to a significantly lower risk of dementia (adjusted HR [aHR] 0.87; 95% CI 0.82 to 0.93).
Glucosamine users vs non-users had a lower risk of incident vascular dementia (aHR 0.82; 95% CI 0.69 to 0.98).
No significant association was observed between glucosamine use and Alzheimer’s disease risk (aHR 0.97; 95% CI 0.86 to 1.08).
Glucosamine use was associated with a lower risk of dementia in patients with T2D over the follow-up (aHR 0.79; 95% CI 0.67 to 0.93).