This site is intended for UK healthcare professionals
Medscape UK Univadis Logo
Medscape UK Univadis Logo
Clinical Summary

Habitual Intake of Fish Oil Supplement Lowers CKD Risk


  • Habitual intake of fish oil supplementation, consumption of oily and non-oily fish, as well as plasma concentration of omega-3 polyunsaturated fatty acid (PUFA) and docosahexaenoic acid (DHA) were associated with a lower risk of chronic kidney disease (CKD).

Why this matters

  • Findings support the use of fish oil and the current dietary recommendation regarding increasing oily fish intake for CKD prevention.

Study design

  • A large-scale longitudinal cohort study of 408,023 UK Biobank participants (aged 37–73 years) who completed a standardised and validated touchscreen food frequency questionnaire on consumption of major foods or food groups and fish oil
  • Funding: National Key Research and Development Program and others.

Key results

  • Overall, 128,843 (31.6%) participants regularly taking fish oil supplements.
  • During a median follow-up of 12.0 years, 10,782 (2.6%) participants reported CKD.
  • Habitual fish oil use vs no use was associated with a significantly lower risk of incident CKD (adjusted HR [aHR] 0.90; 95% CI 0.87 to 0.95).
  • The risk of incident CKD was significantly lower in participants who consumed ≥2 servings/week of (aHR; 95% CI):
    • oily fish (0.86; 0.79 to 0.94; Ptrend=0.002); and
    • nonoily fish (0.86; 0.77 to 0.97; Ptrend=0.057).
  • Plasma concentration of omega-3 polyunsaturated fatty acid (per standard deviation [SD] increment: aHR 0.89; 95% CI 0.84 to 0.94) and docosahexaenoic acid (per SD increment: aHR 0.91; 95% CI 0.87 to 0.96) was associated with a reduced risk of incident CKD.


  • Observational design.
  • Risk of residual confounding.