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Ulcerative Colitis May Independently Predict Hypertension Risk
- Patients with inflammatory bowel disease, especially those with ulcerative colitis, had a higher risk of hypertension than the general population.
Why This Matters
- Findings highlight the need for close monitoring and early management of hypertension in patients with inflammatory bowel disease in clinical practice.
- This was a prospective, observational cohort study that included 281,064 participants (age 37-69 years), identified using data from the UK Biobank (2006-2010).
- Primary outcome: occurrence of hypertension.
- Funding: National Natural Science Foundation of China and others.
- Of 281,064 participants, 2376 (0.8%) were diagnosed with inflammatory bowel disease, including 1418 with ulcerative colitis, 840 with Crohn's disease, and 118 with inflammatory bowel disease unclassified.
- During a median follow-up of 8.1 years, 20,129 (7.2%) participants were diagnosed with hypertension.
- Compared with participants without inflammatory bowel disease, the cumulative risk of hypertension was higher in those with ulcerative colitis (10.9%), Crohn's disease (7.7%), and inflammatory bowel disease unclassified (9.3%; P<0.001 for all).
- Ulcerative colitis was independently associated with a higher risk of subsequent hypertension (adjusted HR [aHR] 1.30; 95% CI 1.11 to 1.52; P=0.001).
- In the subsequent survival analysis and univariate Cox regression analysis, ulcerative colitis was an independent risk factor for the onset of hypertension (aHR 1.56; 95% CI 1.21 to 2.03; P=0.001).