Clinical Summary

Ulcerative Colitis May Independently Predict Hypertension Risk

Vinod Rane, BS Pharm | Disclosures

Takeaway

Patients with inflammatory bowel disease, especially those with ulcerative colitis, had a higher risk of hypertension than the general population.

Findings highlight the need for close monitoring and early management of hypertension in patients with inflammatory bowel disease in clinical practice.

This was a prospective, observational cohort study that included 281,064 participants (age 37-69 years), identified using data from the UK Biobank (2006-2010).
Primary outcome: occurrence of hypertension.
Funding: National Natural Science Foundation of China and others.

Of 281,064 participants, 2376 (0.8%) were diagnosed with inflammatory bowel disease, including 1418 with ulcerative colitis, 840 with Crohn's disease, and 118 with inflammatory bowel disease unclassified.
During a median follow-up of 8.1 years, 20,129 (7.2%) participants were diagnosed with hypertension.
Compared with participants without inflammatory bowel disease, the cumulative risk of hypertension was higher in those with ulcerative colitis (10.9%), Crohn's disease (7.7%), and inflammatory bowel disease unclassified (9.3%; P<0.001 for all).
Ulcerative colitis was independently associated with a higher risk of subsequent hypertension (adjusted HR [aHR] 1.30; 95% CI 1.11 to 1.52; P=0.001).
In the subsequent survival analysis and univariate Cox regression analysis, ulcerative colitis was an independent risk factor for the onset of hypertension (aHR 1.56; 95% CI 1.21 to 2.03; P=0.001).