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Clinical Summary

Ulcerative Colitis May Independently Predict Hypertension Risk


  • Patients with inflammatory bowel disease, especially those with ulcerative colitis, had a higher risk of hypertension than the general population.

Why This Matters

  • Findings highlight the need for close monitoring and early management of hypertension in patients with inflammatory bowel disease in clinical practice.

Study Design

  • This was a prospective, observational cohort study that included 281,064 participants (age 37-69 years), identified using data from the UK Biobank (2006-2010).
  • Primary outcome: occurrence of hypertension.
  • Funding: National Natural Science Foundation of China and others.

Key Results

  • Of 281,064 participants, 2376 (0.8%) were diagnosed with inflammatory bowel disease, including 1418 with ulcerative colitis, 840 with Crohn's disease, and 118 with inflammatory bowel disease unclassified.
  • During a median follow-up of 8.1 years, 20,129 (7.2%) participants were diagnosed with hypertension.
  • Compared with participants without inflammatory bowel disease, the cumulative risk of hypertension was higher in those with ulcerative colitis (10.9%), Crohn's disease (7.7%), and inflammatory bowel disease unclassified (9.3%; P<0.001 for all).
  • Ulcerative colitis was independently associated with a higher risk of subsequent hypertension (adjusted HR [aHR] 1.30; 95% CI 1.11 to 1.52; P=0.001).
  • In the subsequent survival analysis and univariate Cox regression analysis, ulcerative colitis was an independent risk factor for the onset of hypertension (aHR 1.56; 95% CI 1.21 to 2.03; P=0.001).


  • Observational design.